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公开(公告)号：US20230147502A1
公开(公告)日：2023-05-11
申请号：US18061034
申请日：2022-12-02
CPC分类号： A61K47/548 , A61K47/6889 , A61K47/6803 , A61K47/6849 , C07F9/3839 , C07F9/40 , A61P29/00
摘要： Phosphonate linkers and their use for delivering compounds with passive cell permeability into a cell wherein the phosphonate group facilitates cellular retention of the compound are described.
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公开(公告)号：US11883500B2
公开(公告)日：2024-01-30
申请号：US18061034
申请日：2022-12-02
CPC分类号： A61K47/548 , A61K47/6803 , A61K47/6849 , A61K47/6889 , C07F9/3839 , C07F9/40 , A61P29/00 , A61P35/00
摘要： Phosphonate linkers and their use for delivering compounds with passive cell permeability into a cell wherein the phosphonate group facilitates cellular retention of the compound are described.
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公开(公告)号：US20240101555A1
公开(公告)日：2024-03-28
申请号：US18256463
申请日：2021-12-14
申请人： Kira A. Armacost , Maria Irina Chiriac , Danielle M. Hurzy , Jeffery C. Kern , Jian Liu , Peter J. Manley , Phillippe Nantermet , Michael T. Rudd , Vanessa L. Rada , Craig A. Stump , Merck Sharp & Dohme LLC
发明人： Kira A. Armacost , Maria Irina Chiriac , Danielle M. Hurzy , Jeffrey C. Kern , Jian Liu , Peter J. Manley , Philippe Nantermet , Vanessa L. Rada , Michael T. Rudd , Craig A. Stump
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention is directed to urea compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
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公开(公告)号：US20230391795A1
公开(公告)日：2023-12-07
申请号：US18250267
申请日：2021-10-28
发明人： Kira A. Armacost , Maria Irina Chiriac , Danielle M. Hurzy , Jeffrey C. Kern , Jian Liu , Peter J. Manley , Vanessa L. Rada , Michael T. Rudd , Craig A. Stump , Zhe Wu , Dong Xiao
IPC分类号： C07D498/18 , C07D498/22 , C07D513/22
CPC分类号： C07D498/18 , C07D498/22 , C07D513/22
摘要： The present invention is directed to macrocyclic urea compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
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