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公开(公告)号：US20240002397A1
公开(公告)日：2024-01-04
申请号：US18252217
申请日：2021-11-18
发明人： Stephane L. Bogen , Ping Chen , Dane James Clausen , Jian Liu , Michael T. Rudd , Li Xiao , Dexi Yang , Shishi Lin
IPC分类号： C07D498/04 , C07D498/18
CPC分类号： C07D498/04 , C07D498/18
摘要： The present invention is directed to 3-amino pyrrolidine and piperidine macrocyclic compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
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公开(公告)号：US11680060B2
公开(公告)日：2023-06-20
申请号：US17402932
申请日：2021-08-16
发明人： Stephane L. Bogen , Dane James Clausen , Deodial Guy Guiadeen , Jinsong Hao , Shishi Lin , Michael T. Rudd , Lan Wei , Li Xiao , Dexi Yang
IPC分类号： C07D403/14 , C07D207/14 , C07D401/12 , C07D403/12 , C07D405/14 , C07D417/12 , C07D491/048
CPC分类号： C07D403/14 , C07D207/14 , C07D401/12 , C07D403/12 , C07D405/14 , C07D417/12 , C07D491/048
摘要： The present invention is directed to bicyclo[4.1.0]heptane pyrrolidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
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