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公开(公告)号：US08771310B2
公开(公告)日：2014-07-08
申请号：US12514189
申请日：2008-05-28
IPC分类号： A61M29/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/432 , A61L2300/80
摘要： The present invention relates to compositions and methods for improving outcomes in vascular interventional procedures. In particular, the present invention relates to compositions and methods for improving outcomes in vascular interventional procedures using an anti-no-reflow guide wire that attenuates the “no-reflow” phenomenon that is associated with negative outcomes.
摘要翻译： 本发明涉及用于改善血管介入程序结局的组合物和方法。 特别地，本发明涉及使用抗 - 无回流引导线来改善血管介入手术方法的结果的组合物和方法，所述导引线减弱与否定结果相关的“无回流”现象。
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公开(公告)号：US20100036411A1
公开(公告)日：2010-02-11
申请号：US12514189
申请日：2008-05-28
IPC分类号： A61M29/00 , C07H19/16 , C08F251/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/432 , A61L2300/80
摘要： The present invention relates to compositions and methods for improving outcomes in vascular interventional procedures. In particular, the present invention relates to compositions and methods for improving outcomes in vascular interventional procedures using an anti-no-reflow guide wire that attenuates the “no-reflow” phenomenon that is associated with negative outcomes.
摘要翻译： 本发明涉及用于改善血管介入程序结局的组合物和方法。 特别地，本发明涉及使用抗 - 无回流引导线来改善血管介入手术方法的结果的组合物和方法，所述导引线减弱与否定结果相关的“无回流”现象。
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公开(公告)号：US11331418B2
公开(公告)日：2022-05-17
申请号：US17003361
申请日：2020-08-26
IPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , C08L29/04 , C08L39/06 , C09D131/04 , A61K31/7076 , A61K45/06
摘要： The present invention relates to compositions and methods to provide continuous and controlled release of therapeutic agent(s) during a procedure such as an interventional vascular procedure, e.g., to reduce acute and chronic complications and improve outcomes.
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公开(公告)号：US20220288284A1
公开(公告)日：2022-09-15
申请号：US17734889
申请日：2022-05-02
摘要： The present invention relates to compositions and methods to provide continuous and controlled release of therapeutic agent(s) during a procedure such as an interventional vascular procedure, e.g., to reduce acute and chronic complications and improve outcomes.
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公开(公告)号：US20210060215A1
公开(公告)日：2021-03-04
申请号：US17003361
申请日：2020-08-26
摘要： The present invention relates to compositions and methods to provide continuous and controlled release of therapeutic agent(s) during a procedure such as an interventional vascular procedure, e.g., to reduce acute and chronic complications and improve outcomes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US5206222A
公开(公告)日：1993-04-27
申请号：US704058
申请日：1991-05-22
申请人： Mervyn B. Forman , Edwin K. Jackson
发明人： Mervyn B. Forman , Edwin K. Jackson
IPC分类号： A61K31/165 , A61K31/167 , A61K31/70 , A61P9/00 , C07H19/067
CPC分类号： A61K31/70
摘要： This invention relates to a method to treat a heart attack victim to reduce heart muscle damage. In particular, the invention relates to a metGrant StatementThis research was supported in part by the National Institute of Health, Grant R01 HL40892-01.
摘要翻译： 本发明涉及一种治疗心脏病发作受害者以减少心肌损伤的方法。 特别地，本发明涉及一种减少心肌再灌注损伤的方法，通过选择性施用非低血压量的选择性激活腺苷-1受体的化合物，选择性激活腺苷-2受体或腺苷的化合物，全部在存在 有效量的利多卡因。
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7.发明授权Peroxisome-proliferator activated receptor-alpha agonists for organ preservation 有权过氧化物酶体增殖物激活的受体α激动剂用于器官保存公开(公告)号：US07897326B2
公开(公告)日：2011-03-01
申请号：US11687419
申请日：2007-03-16
IPC分类号： A01N1/02 , A61K31/7072 , A61K31/192
CPC分类号： A61K31/192 , A01N1/02 , A01N1/0226 , A61K31/216 , A61K31/505
摘要： Methods and compositions for reducing, preventing or reversing organ damage and/or enhancing organ preservation by administration of a peroxisome-proliferator activated receptor-alpha (PPARα) agonist to the organ.
摘要翻译： 通过向器官施用过氧化物酶体增殖物激活受体α（PPARα）激动剂来减少，预防或逆转器官损伤和/或增强器官保存的方法和组合物。
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8.发明申请PEROXISOME-PROLIFERATOR ACTIVATED RECEPTOR-ALPHA AGONISTS FOR ORGAN PRESERVATION 有权用于组织保存的过氧化物酶 - 促进剂激活的受体-AlpHA激动剂公开(公告)号：US20070218451A1
公开(公告)日：2007-09-20
申请号：US11687419
申请日：2007-03-16
IPC分类号： A01N1/02 , A61K31/7072 , A61K31/192
CPC分类号： A61K31/192 , A01N1/02 , A01N1/0226 , A61K31/216 , A61K31/505
摘要： Methods and compositions for reducing, preventing or reversing organ damage and/or enhancing organ preservation by administration of a peroxisome-proliferator activated receptor-alpha (PPARα) agonist to the organ.
摘要翻译： 通过向器官施用过氧化物酶体增殖物激活受体α（PPARα）激动剂来减少，预防或逆转器官损伤和/或增强器官保存的方法和组合物。
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9.发明授权公开(公告)号：US06566371B2
公开(公告)日：2003-05-20
申请号：US09844255
申请日：2001-04-30
申请人： Edwin K. Jackson
发明人： Edwin K. Jackson
IPC分类号： A61K3152
CPC分类号： A61K31/7076
摘要： A method for preventing or treating gastrointestinal or systemic diseases in a mammalian subject, comprising: the step of administering a therapeutically effective amount of a composition comprising adenosine or a prodrug thereof into the peritoneal cavity of said subject at a dose that does not achieve pharmacologically active levels in the aortic arterial plasma of said subject.
摘要翻译： 一种用于预防或治疗哺乳动物受试者的胃肠道或全身性疾病的方法，包括：以不达到药理学活性的剂量将治疗有效量的包含腺苷或其前体药物的组合物施用于所述受试者的腹膜腔的步骤 所述受试者的主动脉血浆中的水平。
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公开(公告)号：US20080279936A1
公开(公告)日：2008-11-13
申请号：US10268091
申请日：2002-10-10
CPC分类号： A61K31/56
摘要： Methods are provided for the decrease of endothelin production in an individual. In particular, the methods include the reduction of endothelin production by the administration of a composition comprising an estradiol metabolite. Preferred estradiol metabolites include 2-methoxyestradiol, 4-methoxyestradiol, 2-hydroxyestradiol and 4-hydroxyestradiol or prod rugs thereof. The composition may be in the form of a controlled release formulation. The present methods are useful as a therapeutic for a wide variety of disease states.
摘要翻译： 提供减少个体内皮素产生的方法。 特别地，所述方法包括通过施用包含雌二醇代谢物的组合物来减少内皮素的产生。 优选的雌二醇代谢物包括2-甲氧基雌二醇，4-甲氧基雌二醇，2-羟基雌二醇和4-羟基雌二醇或其生物地毯。 组合物可以是控释制剂的形式。 本发明的方法可用作多种疾病状态的治疗剂。
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