公开(公告)号：US20220089575A1

公开(公告)日：2022-03-24

申请号：US17538394

申请日：2021-11-30

Applicant: Metacrine, Inc.

Inventor： Nicholas D. SMITH ,  Steven P. GOVEK ,  Johnny Y. NAGASAWA ,  Karensa L. DOUGLAS ,  Andiliy G. LAI

IPC: C07D403/12 ,  C07D417/12 ,  C07D275/02 ,  C07D413/12 ,  C07D417/04 ,  C07D231/12 ,  C07D401/12 ,  C07D277/28 ,  A61P1/16 ,  C07D413/14 ,  C07D417/14 ,  C07D263/32 ,  C07D401/14

Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

公开(公告)号：US20220056019A1

公开(公告)日：2022-02-24

申请号：US17276785

申请日：2019-09-17

Applicant: Metacrine, Inc.

Inventor： Nicholas D. SMITH ,  Steven P. GOVEK ,  Johnny Y. NAGASAWA ,  Andiliy G. LAI ,  Karensa L. DOUGLAS

IPC: C07D413/14 ,  C07D401/14 ,  C07D417/04 ,  C07D403/12 ,  C07D401/12 ,  C07D231/12 ,  C07D405/14 ,  C07D413/04 ,  C07D417/14 ,  C07D403/14 ,  C07D409/14

Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

公开(公告)号：US20210395253A1

公开(公告)日：2021-12-23

申请号：US17349757

申请日：2021-06-16

Applicant: Metacrine, Inc.

Inventor： Nicholas D. SMITH ,  Steven P. GOVEK ,  Karensa L. DOUGLAS ,  Andiliy G. LAI

IPC: C07D471/14 ,  C07D487/04 ,  C07D417/14 ,  C07D413/14

Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.