公开(公告)号：US09580459B2

公开(公告)日：2017-02-28

申请号：US14261963

申请日：2014-04-25

申请人： Metselex, Inc.

发明人： Peter Ian Dosa ,  Clifford John Steer ,  Ingrid Gunda Georg

IPC分类号： C07J51/00

CPC分类号： C07J51/00

摘要： Ursodeoxycholic acid (UDCA) is a bile acid with demonstrated anti-apoptotic activity in both in vitro and in vivo models. Water-soluble prodrugs of UDCA for use in indications where intravenous administration of UDCA may be preferable, such as reducing damage from stroke or acute kidney injury, are disclosed. The disclosed prodrugs showed significant anti-apoptotic activity in a series of in vitro assays.

摘要翻译： 熊去氧胆酸（UDCA）是一种在体外和体内模型中都具有抗凋亡活性的胆汁酸。 公开了用于UDCA的静脉内给药可能是优选的适应症的UDCA的水溶性前药，例如减轻中风或急性肾损伤的损伤。 所公开的前药在一系列体外测定中显示出显着的抗细胞凋亡活性。

公开(公告)号：US20140323748A1

公开(公告)日：2014-10-30

申请号：US14261963

申请日：2014-04-25

申请人： Metselex, Inc.

发明人： Peter Ian Dosa ,  Clifford John Steer ,  Ingrid Gunda Georg

IPC分类号： C07J51/00

CPC分类号： C07J51/00

摘要： Ursodeoxycholic acid (UDCA) is a bile acid with demonstrated anti-apoptotic activity in both in vitro and in vivo models. Water-soluble prodrugs of UDCA for use in indications where intravenous administration of UDCA may be preferable, such as reducing damage from stroke or acute kidney injury, are disclosed. The disclosed prodrugs showed significant anti-apoptotic activity in a series of in vitro assays.

摘要翻译： 熊去氧胆酸（UDCA）是一种在体外和体内模型中都具有抗凋亡活性的胆汁酸。 公开了用于UDCA的静脉内给药可能是优选的适应症的UDCA的水溶性前药，例如减轻中风或急性肾损伤的损伤。 所公开的前药在一系列体外测定中显示出显着的抗细胞凋亡活性。