公开(公告)号：US20230374452A1

公开(公告)日：2023-11-23

申请号：US18030965

申请日：2021-10-06

Applicant: MiCAN Technologies Inc. ,  OSAKA UNIVERSITY

Inventor： Jun Shimizu ,  Naomi Tanga ,  Misuzu Yamada ,  Kazuo Miyazaki ,  Tatsuo Shioda ,  Emi Nakayama ,  Tadahiro Sasaki ,  Ritsuko Koketsu

IPC: C12N5/078 ,  C07K14/53 ,  C12N9/48 ,  C12Q1/70 ,  C12N5/10 ,  C12N7/02

CPC classification number: C12N5/0634 ,  C07K14/53 ,  C12N9/485 ,  C12Q1/70 ,  C12N5/10 ,  C12N7/02 ,  C12Y304/17023

Abstract: The present invention provides human cells that can be stably infected with coronavirus, as human cells for research on infection with coronavirus such as SARS-CoV-2, as well as, by utilizing the cells, a method for confirming the presence of a coronavirus in a sample, a method for producing a coronavirus, and a method for evaluating the presence or absence of anti-coronavirus activity of a test sample or a substance having an anti-coronavirus neutralizing action in a test sample. Specifically, the present invention relates to a method for preparing a coronavirus-infectious immortalized human myeloid cell, including introducing ACE2 and TMPRSS2 into an immortalized human myeloid cell, and the like.

公开(公告)号：US11560421B2

公开(公告)日：2023-01-24

申请号：US16968470

申请日：2019-02-08

Applicant: OSAKA UNIVERSITY ,  MAHIDOL UNIVERSITY

Inventor： Tatsuo Shioda ,  Emi Nakayama ,  Tadahiro Sasaki ,  Orapim Puiprom ,  Aekkachai Tuekprakhon ,  Pornsawan Leaungwutiwong ,  Natthanej Luplertlop

IPC: C07K16/10 ,  G01N33/569

Abstract: The present invention provides a new antibody against ECSA type Chikungunya virus, WA type Chikungunya virus, and Asian type Chikungunya virus or an antigen-binding fragment of the antibody. The antibody against Chikungunya virus or the antigen-binding fragment of the antibody of the present invention includes a heavy chain variable region or a heavy chain (1), (2), or (3) and a light chain variable region or a light chain (4).