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公开(公告)号：US06723342B1
公开(公告)日：2004-04-20
申请号：US09632228
申请日：2000-08-04
申请人： Michael Augello , Sheila M. Dell , Domingo C. Tuason , James J. Modliszewski , Thomas A. Ruszkay , David E. Werner
发明人： Michael Augello , Sheila M. Dell , Domingo C. Tuason , James J. Modliszewski , Thomas A. Ruszkay , David E. Werner
IPC分类号： A61K936
CPC分类号： A61K9/286 , A61K9/284 , A61K9/2866
摘要： An edible, hardenable coating composition containing microcrystalline cellulose and carrageenan and at least one of a strengthening polymer, a plasticizer, a surface active agent or a combination thereof. The coating composition of the present invention may be applied to pharmaceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods and provides an elegant prompt release coating which does not retard the release of active ingredients from the coated substrate.
摘要翻译： 一种含有微晶纤维素和角叉菜胶的可食用，可硬化的涂料组合物和至少一种强化聚合物，增塑剂，表面活性剂或其组合。 本发明的涂料组合物可以应用于药物和兽用固体剂型，糖果，种子，动物饲料，肥料，农药片和食品，并提供优雅的快速释放涂层，其不会阻止活性成分从 涂层基材。
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公开(公告)号：US06709713B2
公开(公告)日：2004-03-23
申请号：US10165022
申请日：2002-06-07
申请人： Michael Augello , Sheila M. Dell , Domingo C. Tuason , James J. Modliszewski , Thomas A. Ruszkay , David E. Werner
发明人： Michael Augello , Sheila M. Dell , Domingo C. Tuason , James J. Modliszewski , Thomas A. Ruszkay , David E. Werner
IPC分类号： A61K936
CPC分类号： A61K9/2866 , A61K9/284 , A61K9/286
摘要： An edible, hardenable coating composition containing microcrystalline cellulose and carrageenan and either a strengthening polymer, a plasticizer or both. The coating composition of the present invention may be applied to pharmaceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods and provides an elegant prompt release coating which does not retard the release of active ingredients from the coated substrate.
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公开(公告)号：US06432448B1
公开(公告)日：2002-08-13
申请号：US09491724
申请日：2000-01-27
申请人： Michael Augello , Sheila M. Dell , Domingo C. Tuason , James J. Modliszewski , Thomas A. Ruszkay , David E. Werner
发明人： Michael Augello , Sheila M. Dell , Domingo C. Tuason , James J. Modliszewski , Thomas A. Ruszkay , David E. Werner
IPC分类号： A61K936
CPC分类号： A61K9/2866 , A61K9/284 , A61K9/286
摘要： An edible, hardenable coating composition containing microcrystalline cellulose and carrageenan and either a strengthening polymer, a plasticizer or both. The coating composition of the present invention may be applied to pharmaceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods and provides an elegant prompt release coating which does not retard the release of active ingredients from the coated substrate.
摘要翻译： 含有微晶纤维素和角叉菜胶以及强化聚合物，增塑剂或两者的可食用，可硬化的涂料组合物。 本发明的涂料组合物可以应用于药物和兽用固体剂型，糖果，种子，动物饲料，肥料，农药片和食品，并提供优雅的快速释放涂层，其不会阻止活性成分从 涂层基材。
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公开(公告)号：US6099865A
公开(公告)日：2000-08-08
申请号：US330445
申请日：1999-06-11
CPC分类号： A61K9/1652 , A61K9/0056 , A61K9/5047 , A61K9/2054 , A61K9/2077 , A61K9/2081
摘要： The present invention describes the use of croscarmellose sodium to coat bitter-tasting active agents in a manner that will mask the bitter taste of these materials, taste masked pharmaceutical compositions in which the particles of pharmaceutically active agent are coated with croscarmellose sodium, taste masked pharmaceutical tablets made therefrom, in which the rapid disintegration of tablets that is imparted by croscarmellose sodium is preserved, and to a method for preparing such coated particles by preparing them in a fluidized bed coating process.
摘要翻译： 本发明描述了使用交联羧甲基纤维素钠以掩蔽这些材料的苦味的方式涂上苦味活性剂，其中药物活性剂颗粒用交联羧甲纤维素钠涂覆的掩味药物组合物，掩味药剂 由其制备的片剂，其中保存了由交联羧甲基纤维素钠赋予的片剂的快速崩解，以及通过在流化床包衣方法中制备这些包衣颗粒的方法。
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公开(公告)号：US06500462B1
公开(公告)日：2002-12-31
申请号：US09696780
申请日：2000-10-26
IPC分类号： A61K916
CPC分类号： A61K9/2866 , A61K9/284 , A61K9/2853 , A61K9/286
摘要： An edible, hardenable coating composition is disclosed containing microcrystalline cellulose, a film forming amount of propylene glycol alginate, and a strengthening polymer, optionally in combination with at least one of a plasticizer, a surfactant, or a filler. The coating composition of the present invention may be applied to pharmaceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods and provides an elegant prompt release coating which does not retard the release of active ingredients from the coated substrate.
摘要翻译： 公开了一种可食用的可硬化涂料组合物，其包含微晶纤维素，成膜量的丙二醇藻酸盐和强化聚合物，任选地与增塑剂，表面活性剂或填料中的至少一种组合。 本发明的涂料组合物可以应用于药物和兽用固体剂型，糖果，种子，动物饲料，肥料，农药片和食品，并提供优雅的快速释放涂层，其不会阻止活性成分从 涂层基材。
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公开(公告)号：US5904937A
公开(公告)日：1999-05-18
申请号：US942962
申请日：1997-10-03
CPC分类号： A61K9/1652 , A61K31/192 , A61K9/0056
摘要： The present invention discloses the taste masking of drugs by wet granulating the drug with a microcrystaline cellulose compositions then spheronizing the granulation into spheres having a smooth uniform surface and a particle size in the range of 1 to 1000 microns.
摘要翻译： 本发明公开了通过用微晶纤维素组合物湿法造粒药物的药物的掩味，然后将造粒球化成具有1至1000微米范围内的光滑均匀表面和粒度的球体。
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公开(公告)号：US5955107A
公开(公告)日：1999-09-21
申请号：US989787
申请日：1997-12-12
CPC分类号： A61K9/0095 , A61K9/0056
摘要： Rapidly disintegrating and readily suspendible tablets and their method of preparation are disclosed in which there is a therapeutic amount of a pharmacologically active ingredient, 1 to 6 percent croscarmellose sodium, 10 to 50 percent microcrystalline cellulose, and 10 to 50 percent of a coprocessed additive consisting essentially of 75 to 95 percent microcrystalline cellulose and 5 to 25 percent calcium, sodium alginate complex. The tablets are suitable for oral administration of measured-dose suspensions of either water soluble or water insoluble pharmaceuticals.
摘要翻译： 公开了快速崩解和容易悬浮的片剂及其制备方法，其中存在治疗量的药理活性成分，1至6％交联羧甲基纤维素钠，10至50％微晶纤维素和10至50％的协同加工添加剂， 基本上为75至95％的微晶纤维素和5至25％的钙，藻酸钠复合物。 片剂适合于口服施用水溶性或水不溶性药物的测量剂量悬浮液。
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公开(公告)号：US6037380A
公开(公告)日：2000-03-14
申请号：US88772
申请日：1998-06-02
CPC分类号： D21C9/007 , C08B15/02 , C08L1/02 , Y10S514/819 , Y10S514/937
摘要： Ultra-fine microcrystalline cellulose compositions are disclosed which produce highly stable suspensions and/or dispersions in which substantially all of the microcrystalline cellulose has a particle size not greater than about 0.7 .mu.m. The compositions include an attriting aid which has a dual functionality, assisting in reducing the size of the cellulose microcrystals and adding a desired property or ingredient to the dispersions or other product in which the compositions are utilized.
摘要翻译： 公开了超细微晶纤维素组合物，其产生高度稳定的悬浮液和/或分散体，其中基本上所有的微晶纤维素具有不大于约0.7μm的粒度。 组合物包括具有双重功能性的助磨剂，有助于减小纤维素微晶的尺寸，并将所需的性质或成分添加到其中使用组合物的分散体或其它产物中。
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公开(公告)号：US5840768A
公开(公告)日：1998-11-24
申请号：US869039
申请日：1997-06-04
IPC分类号： A61K9/107 , A61K9/00 , A61K31/167 , A61K31/192 , A61K47/36 , A61K47/38 , A61K47/00 , A61K31/16 , A61K31/19 , A61K33/08
CPC分类号： A61K9/0095 , A61K31/167 , A61K31/192 , A61K47/38 , A61K47/36
摘要： Novel pharmaceutical suspensions comprising a pharmaceutically active ingredient suspended in aqueous media with a suspending agent comprising attrited microcrystalline cellulose coprocessed and at least partially surface coated with a calcium sodium alginate salt complex barrier dispersant and readily dispersible and hydratable dry formulations thereof are described and exemplified.
摘要翻译： 描述和示例了新型药物悬浮液，其包含悬浮在水性介质中的药物活性成分与悬浮剂，所述悬浮剂包含共磨加工并至少部分地表面涂覆有藻酸钙盐复合物阻隔性分散剂和易于分散和可水合的干燥制剂的磨碎的微晶纤维素。
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