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    Lyophilized imaging agent formulation comprising a chemotactic peptide
    4.
    发明授权
    Lyophilized imaging agent formulation comprising a chemotactic peptide 失效
    包含趋化肽的冻干成像剂制剂

    公开(公告)号：US6024938A

    公开(公告)日：2000-02-15

    申请号：US997894

    申请日：1997-12-24

    Applicant: Diane C. Corbo ,  Mary Jean M. Link ,  N. Adeyinka Williams ,  Michelle L. Tomsho ,  Michael Bornstein ,  Howard F. Solomon ,  Scott K. Larsen ,  Robert L. Suddith

    Inventor： Diane C. Corbo ,  Mary Jean M. Link ,  N. Adeyinka Williams ,  Michelle L. Tomsho ,  Michael Bornstein ,  Howard F. Solomon ,  Scott K. Larsen ,  Robert L. Suddith

    IPC: A61K51/10 ,  A61K51/00 ,  A61M36/14

    CPC classification number: A61K51/1093

    Abstract: A lyophilized imaging agent formulation and methods for making same are disclosed, such formulations comprise a targeting molecule such as antibody or chemotactic peptide, a linker such as diethylenetriaminepentaacetic acid (DTPA) or succinimidyl 6-hydrazinium nicotinate hydrochloride (SHNH), drying protectant such as mannitol, maltose or tricine, and excipient such as polysorbate 80, in citrate buffer. The formulations of the invention are lyophilized and may be stored stably for extended periods of time. Following reconstitution with diluent, the formulations are administered to a subject for scintigraphic imaging or therapeutic use. Also contemplated is a kit comprising a two-vial system wherein a first vial comprises a lyophilized formulation of imaging agent in the form of a lyophilized cake, and a second vial comprises a pharmaceutically acceptable carrier or diluent.

    Abstract translation: 公开了冻干显影剂制剂及其制备方法，该制剂包括靶向分子如抗体或趋化肽，连接体如二亚乙基三胺五乙酸（DTPA）或琥珀酰亚胺基6-肼基烟酸盐酸盐（SHNH），干燥保护剂如 甘露醇，麦芽糖或tricine，以及赋形剂如聚山梨醇酯80，在柠檬酸盐缓冲液中。 本发明的制剂被冻干，并且可以稳定地储存较长时间。 在用稀释剂重构后，将制剂施用于受试者进行闪烁照相成像或治疗用途。 还考虑了一种包含双小瓶系统的试剂盒，其中第一小瓶包含冻干饼形式的成像剂的冻干制剂，第二小瓶包含药学上可接受的载体或稀释剂。

    System and method for authenticating a signature on a comic book for grading and encapsulation
    5.
    发明申请
    System and method for authenticating a signature on a comic book for grading and encapsulation 审中-公开
    在漫画书上认证签名的系统和方法，用于分级和封装

    公开(公告)号：US20160292695A1

    公开(公告)日：2016-10-06

    申请号：US14794686

    申请日：2015-07-08

    Applicant: Michael Bornstein

    Inventor： Michael Bornstein

    IPC: G06Q30/00 ,  G06Q30/02 ,  B42D3/08

    CPC classification number: G06Q30/018 ,  B42D3/08 ,  B65D25/54 ,  B65D81/02 ,  B65D85/54 ,  G06Q30/0278

    Abstract: A system and method for grading a document are disclosed, the method including but not limited to generating on a comic grading processor, a grade for a first comic book using grading notes for the first comic book from a first comic book grader; generating a quick scan code for the grading notes; accepting at the comic grading processor, a Quick Scan code from a mobile device; and sending from the comic book grading processor to the mobile device a grading report comprising the grade and grading notes indicated by the quick response code. A system is disclosed for practicing the method.

    Abstract translation: 公开了一种用于对文档进行分级的系统和方法，所述方法包括但不限于在漫画分级处理器上生成第一漫画的等级，其使用来自第一漫画书分级机的第一漫画书的分级笔记; 生成分级笔记的快速扫描代码; 在漫画分级处理器接受来自移动设备的快速扫描代码; 并从漫画分级处理器向移动设备发送包括由快速响应代码指示的等级和分级笔记的分级报告。 公开了一种用于实施该方法的系统。

    Bow spring detector for gripper mechanism
    6.
    发明授权
    Bow spring detector for gripper mechanism 失效
    弓形弹簧检测器用于夹持机构

    公开(公告)号：US4531726A

    公开(公告)日：1985-07-30

    申请号：US442952

    申请日：1982-11-19

    Applicant: Michael Bornstein

    Inventor： Michael Bornstein

    IPC: B65H5/10 ,  B65H7/12

    CPC classification number: B65H7/12 ,  B65H5/10

    Abstract: The movable jaw on a gripper mechanism is engaged by a bowed spring feeler element to effect a change in its lateral deflection thereof at a maximum magnification ratio to displacement of the movable jaw from an operative position gripping a single sheet of paper. Deformation of the feeler element is regulated by a bearing abutment spaced from a contact sensing assembly through which the intermediate portion of the element extends to monitor the paper gripping operation.

    Abstract translation: 夹持机构上的活动夹爪由弓形弹簧触发元件接合，以最大放大倍数使其侧向偏转发生变化，从而可移动夹爪与夹持单张纸的操作位置的位移。 触发元件的变形由与接触检测组件间隔开的轴承支座调节，通过该接触检测组件，元件的中间部分延伸以便监控纸张夹持操作。

    Method of preparing a rapidly dissolving powder of sterile crystalline cefazolin sodium for parenteral administration
    8.
    发明授权
    Method of preparing a rapidly dissolving powder of sterile crystalline cefazolin sodium for parenteral administration 失效
    制备无菌结晶头孢唑啉钠快速溶解粉末用于肠胃外给药的方法

    公开(公告)号：US4146971A

    公开(公告)日：1979-04-03

    申请号：US860365

    申请日：1977-12-14

    Applicant: Michael Bornstein ,  Michael D. Cise

    Inventor： Michael Bornstein ,  Michael D. Cise

    IPC: C07D501/00 ,  A61K9/08 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/36 ,  F26B5/06

    CPC classification number: A61K31/545

    Abstract: Sterile, essentially crystalline cefazolin sodium for parenteral administration is prepared by a freeze-drying process wherein a C.sub.1 -C.sub.3 alcohol-water solution of cefazolin sodium containing about 10 percent by volume of the C.sub.1 -C.sub.3 alcohol is chilled slowly from room temperature to about -10.degree. C. over a 3-12 hour period and then rapidly cooled to -30.degree. to about -40.degree. C. and held for 1-2 hours before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the frozen solvent therefrom. The resulting powder dissolves rapidly in acceptable pharmaceutical diluents.

    Abstract translation: 用于肠胃外给药的无菌，基本上结晶的头孢唑啉钠通过冷冻干燥方法制备，其中含有约10体积％的C1-C3醇的头孢唑啉钠的C1-C3醇 - 水溶液从室温缓慢冷却至约 - 10℃，3-12小时，然后迅速冷却至-30℃至约-40℃，并保持1-2小时，然后使所述冷冻溶液进行高真空和适度的热量以升华 冷冻溶剂。 所得粉末在可接受的药物稀释剂中快速溶解。

    Cefazolin suspension for parenteral administration
    9.
    发明授权
    Cefazolin suspension for parenteral administration 失效
    头孢唑林悬浮液用于肠胃外给药

    公开(公告)号：US4029782A

    公开(公告)日：1977-06-14

    申请号：US573283

    申请日：1975-04-28

    Applicant: Michael Bornstein

    Inventor： Michael Bornstein

    IPC: A61K9/00 ,  A61K31/545 ,  A61K31/54

    CPC classification number: A61K9/0019 ,  A61K31/545

    Abstract: A pharmaceutical suspension for parenteral administration is provided which comprises finely divided crystals of cefazolin suspended in a vehicle composed of water, a pharmaceutically acceptable surfactant, lecithin and a viscosity adjusting agent or agents. Methods are also provided for preparing such a suspension.

    Abstract translation: 提供了用于肠胃外给药的药物悬浮液，其包含悬浮在由水，药学上可接受的表面活性剂，卵磷脂和粘度调节剂或试剂组成的载体中的头孢唑啉的细碎晶体。 还提供了制备这种悬浮液的方法。

    System and Method for Authenticating a Signature on a Comic Book for Grading and Encapsulation
    10.
    发明申请
    System and Method for Authenticating a Signature on a Comic Book for Grading and Encapsulation 审中-公开
    用于鉴定漫画书上的签名的系统和方法，用于分级和封装

    公开(公告)号：US20160148284A1

    公开(公告)日：2016-05-26

    申请号：US14725758

    申请日：2015-05-29

    Applicant: Michael Bornstein

    Inventor： Michael Bornstein

    IPC: G06Q30/02 ,  G06K19/06

    CPC classification number: G06Q30/0278

    Abstract: A system and method for grading a document are disclosed, the method including but not limited to generating on a comic grading processor, a grade for a first comic book using grading notes for the first comic book from a first comic book grader; generating a quick scan code for the grading notes; accepting at the comic grading processor, a Quick Scan code from a mobile device; and sending from the comic book grading processor to the mobile device a grading report comprising the grade and grading notes indicated by the quick response code. A system is disclosed for practicing the method.

    Abstract translation: 公开了一种用于对文档进行分级的系统和方法，所述方法包括但不限于在漫画分级处理器上生成第一漫画的等级，其使用来自第一漫画书分级机的第一漫画书的分级笔记; 生成分级笔记的快速扫描代码; 在漫画分级处理器接受来自移动设备的快速扫描代码; 并从漫画分级处理器向移动设备发送包括由快速响应代码指示的等级和分级笔记的分级报告。 公开了一种用于实施该方法的系统。

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