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公开(公告)号：US20050119484A1
公开(公告)日：2005-06-02
申请号：US10506702
申请日：2003-03-04
申请人： Michael Breslin , Paul Coleman , Christopher Cox , J. christopher Culberson , George Hartman , Brenda Mariano , Maricel Torrent
发明人： Michael Breslin , Paul Coleman , Christopher Cox , J. christopher Culberson , George Hartman , Brenda Mariano , Maricel Torrent
IPC分类号： A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/00 , A61P35/00 , C07D231/06 , C07D231/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D417/04 , C07D43/02
CPC分类号： C07D401/04 , C04B35/632 , C07D231/06 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D417/04
摘要： The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，治疗与KSP驱动蛋白活性相关的疾病和用于抑制KSP驱动蛋白的二氢吡唑化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20060100191A1
公开(公告)日：2006-05-11
申请号：US10531495
申请日：2003-10-14
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4025 , A61K31/401 , C07D413/02 , C07D403/02
CPC分类号： C07D405/12 , C07D207/20 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
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公开(公告)号：US09303943B2
公开(公告)日：2016-04-05
申请号：US14221055
申请日：2014-03-20
申请人： Michael Breslin
发明人： Michael Breslin
CPC分类号： F41B5/0094 , F41B7/00
摘要： A stringed weapon for launching shafted projectiles while eliminating a flat spring construction. Specifically, the stringed weapon herein utilizes a torsional spring, and particularly a torsional coil spring, to provide for the force to move the string and, thus, fire the projectile.
摘要翻译： 一种用于发射轴向射弹的有弹弓的武器，同时消除了一个平的弹簧结构。 具体来说，这里的弦乐器利用扭转弹簧，特别是扭转螺旋弹簧来提供力来移动琴弦，从而使射弹发射。
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公开(公告)号：US20050223933A1
公开(公告)日：2005-10-13
申请号：US10804529
申请日：2004-03-19
申请人： Patrick Crosbie , Michael Breslin , James Hinckley
发明人： Patrick Crosbie , Michael Breslin , James Hinckley
CPC分类号： B61B1/02
摘要： A portable platform structure includes a platform, which bridges a thoroughfare to permit pedestrian traffic to cross over the thoroughfare. A trolley may be coupled to the platform, which supports a wheel system, and wheels are included in the wheel system to engage a surface of the thoroughfare or a track on the thoroughfare to permit the portable platform structure to be moved along the thoroughfare to permit placement of the platform structure.
摘要翻译： 便携式平台结构包括一个平台，桥接通道以允许行人交通穿越通道。 手推车可以联接到平台，其支撑车轮系统，并且轮子被包括在车轮系统中以接合通道的表面或通道上的轨道，以允许便携式平台结构沿着通道移动以允许 放置平台结构。
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公开(公告)号：US20140283802A1
公开(公告)日：2014-09-25
申请号：US14221055
申请日：2014-03-20
申请人： Michael Breslin
发明人： Michael Breslin
IPC分类号： F41B5/00
CPC分类号： F41B5/0094 , F41B7/00
摘要： A stringed weapon for launching shafted projectiles while eliminating a flat spring construction. Specifically, the stringed weapon herein utilizes a torsional spring, and particularly a torsional coil spring, to provide for the force to move the string and, thus, fire the projectile.
摘要翻译： 一种用于发射轴向射弹的有弹弓的武器，同时消除了一个平的弹簧结构。 具体来说，这里的弦乐器利用扭转弹簧，特别是扭转螺旋弹簧来提供力来移动琴弦，从而使射弹发射。
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