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公开(公告)号：US5478807A
公开(公告)日：1995-12-26
申请号：US902637
申请日：1992-06-23
CPC分类号： C07K14/64 , A61K38/2221 , C07K14/72
摘要： The invention concerns the use of relaxin or another compound capable of specific binding of a relaxin receptor in the heart in the cardiovascular therapy, and specifically in the treatment of acute and chronic heart failure or of a condition characterized by pathologically low heart rate. The invention further concerns the treatment of neurodegenerative diseases using relaxin or other compounds capable of selectively binding a relaxin receptor in the brain.
摘要翻译： 本发明涉及在心血管治疗中使用松弛素或能够在心脏中特异性结合松弛素受体的另一种化合物，特别涉及治疗急性和慢性心力衰竭或病理学上低心率特征的病症。 本发明还涉及使用松弛素或能够选择性结合脑中的松弛素受体的其它化合物来治疗神经变性疾病。
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2.发明申请公开(公告)号：US20090274689A1
公开(公告)日：2009-11-05
申请号：US12107050
申请日：2008-04-21
IPC分类号： A61K39/395 , A61P9/00
CPC分类号： C07K16/2845 , A61K38/49 , A61K39/3955 , A61K2039/505 , C07K16/2821 , C07K2317/24 , C07K2317/54 , C07K2317/76 , Y10S514/822 , A61K2300/00
摘要： A method for improving clinical outcome in focal ischemic stroke in a mammal by increasing cerebral blood flow and/or reducing infarct size is described which involves administering an effective amount of an anti-CD18 antibody to the mammal, in the absence of removal of the arterial obstruction.
摘要翻译： 描述了一种通过增加脑血流量和/或降低梗死面积来改善哺乳动物局部缺血性卒中临床结果的方法，其涉及在没有移除动脉的情况下向哺乳动物施用有效量的抗CD18抗体 梗阻。
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公开(公告)号：US5914112A
公开(公告)日：1999-06-22
申请号：US788800
申请日：1997-01-22
IPC分类号： A61K38/00 , A61P9/10 , C07K16/28 , A61K39/395
CPC分类号： C07K16/2845 , A61K38/00 , C07K2317/24
摘要： A method for improving clinical outcome in focal ischemic stroke in a mammal by increasing cerebral blood flow and/or reducing infarct size is described which involves administering an effective amount of an anti-CD18 antibody to the mammal, in the absence of removal of the arterial obstruction.
摘要翻译： 描述了一种通过增加脑血流量和/或降低梗死面积来改善哺乳动物局部缺血性卒中临床结果的方法，其涉及在没有移除动脉的情况下向哺乳动物施用有效量的抗CD18抗体 梗阻。
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4.发明授权Co-administration of a tissue plasminogen activator, anti-CD11b antibody and anti-CD18 antibody in stroke 失效组织纤溶酶原激活剂，抗CD11b抗体和抗CD18抗体在中风中共同给药公开(公告)号：US07655230B2
公开(公告)日：2010-02-02
申请号：US12107050
申请日：2008-04-21
IPC分类号： A61K39/395 , A61K38/49 , C07K16/28
CPC分类号： C07K16/2845 , A61K38/49 , A61K39/3955 , A61K2039/505 , C07K16/2821 , C07K2317/24 , C07K2317/54 , C07K2317/76 , Y10S514/822 , A61K2300/00
摘要： A method for improving clinical outcome in focal ischemic stroke in a mammal by increasing cerebral blood flow and/or reducing infarct size is described which involves administering an effective amount of an anti-CD18 antibody to the mammal, in the absence of removal of the arterial obstruction.
摘要翻译： 描述了一种通过增加脑血流量和/或降低梗死面积来改善哺乳动物局部缺血性卒中临床结果的方法，其涉及在没有移除动脉的情况下向哺乳动物施用有效量的抗CD18抗体 梗阻。
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