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1.发明授权Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers 失效特异性检测癌细胞的抗原结合片段，编码片段的核苷酸及其用于预防和检测癌症的用途公开(公告)号：US06207153B1
公开(公告)日：2001-03-27
申请号：US08862124
申请日：1997-05-22
IPC分类号： A61K39395
CPC分类号： C07K16/30 , A61K38/00 , A61K51/1045 , A61K51/1093
摘要： The present invention relates to monoclonal antibody H11 and antigen binding fragments that specifically bind to the antigen recognized by H11, the C-antigen. The C-antigen is found specifically on neoplastic cells and not on normal cells. Also disclosed are polynucleotide and polypeptide derivatives based on H11, including single chain V region molecules and fusion proteins, and various pharmaceutical compositions. When administered to an individual, the H11 antibody is effective in diagnosing, localizing, and/or treating neoplasias. The invention further provides methods for treating a neoplastic disease, particularly melanoma, neuroblastoma, glioma, soft tissue sarcoma, and small cell lung carcinoma. Patients who are in remission as a result of traditional modes of cancer therapy may be treated with a composition of this invention in hopes of reducing the risk of recurrence. Patients may also be treated concurrently with the antibodies and traditional anti-neoplastic agents.
摘要翻译： 本发明涉及特异性结合被H11识别的抗原，C-抗原的单克隆抗体H11和抗原结合片段。 C抗原特异性地发现于肿瘤细胞，而不是在正常细胞上。 还公开了基于H11的多核苷酸和多肽衍生物，包括单链V区分子和融合蛋白，以及各种药物组合物。 当给予个体时，H11抗体在诊断，定位和/或治疗肿瘤中是有效的。 本发明还提供了治疗肿瘤性疾病，特别是黑素瘤，神经母细胞瘤，神经胶质瘤，软组织肉瘤和小细胞肺癌的方法。 作为传统癌症治疗方式缓解的患者可以用本发明的组合物治疗，希望降低复发的风险。 患者也可以与抗体和传统的抗肿瘤剂同时治疗。
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公开(公告)号：US07115722B1
公开(公告)日：2006-10-03
申请号：US09194164
申请日：1997-05-22
CPC分类号： C07K14/4748
摘要： The present invention relates to monoclonal antibody H11 and antigen binding fragments that specifically bind to the antigen recognized by H11, the C-antigen. The C-antigen is found specifically on neoplastic cells and not on normal cells. Also disclosed are polynucleotide and polypeptide derivatives based on H11, including single chain V region molecules and fusion proteins, and various pharmaceutical compositions. When administered to an individual, the H11 antibody is effective in diagnosing, localizing, and/or treating neoplasias. The invention further provides methods for treating a neoplastic disease, particularly melanoma, neuroblastoma, glioma, soft tissue sarcoma, and small cell lung carcinoma. Patients who are in remission as a result of traditional modes of cancer therapy may be treated with a composition of this invention in hopes of reducing the risk of recurrence. Patients may also be treated concurrently with the antibodies and traditional anti-neoplastic agents.
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3.发明授权Human monoclonal antibodies specific to cell cycle independent glioma surface antigen 失效人单克隆抗体特异于细胞周期独立的胶质瘤表面抗原
公开(公告)号：US5639863A
公开(公告)日：1997-06-17
申请号：US264093
申请日：1994-06-21
申请人： Michael D. Dan
发明人： Michael D. Dan
IPC分类号： C12N15/09 , A61K38/00 , C07K7/06 , C07K14/47 , C07K16/30 , C07K16/46 , C12N15/13 , C12P21/08 , C07K16/18
CPC分类号： C07K16/3053 , A61K38/00 , Y10S530/865 , Y10S530/866
摘要： The variable chains of two human monoclonal antibodies (HMAbs) of the IgM isotype are characterized by elucidation of cDNAs encoding those chains. The HMAbs are specific against cell cycle independent, glioma-associated antigen, and the antibodies do not recognize cultured normal human astrocytes. Immunoconjugates based on the sequences identified should target both proliferating and non-proliferating glioma cells in vivo, thus providing a valuable adjunctive therapy in the treatment of these tumors.
摘要翻译： IgM同种型的两种人单克隆抗体（HMAb）的可变链的特征在于阐明编码这些链的cDNA。 HMAb特异性针对与细胞周期无关的胶质瘤相关抗原，并且抗体不识别培养的正常人星形胶质细胞。 基于鉴定的序列的免疫缀合物应靶向体内增殖和非增殖性神经胶质瘤细胞，从而为治疗这些肿瘤提供了有价值的辅助疗法。
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