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1.发明授权公开(公告)号：US06228622B1
公开(公告)日：2001-05-08
申请号：US09427242
申请日：1999-10-26
申请人： Michael G. Sturr , Michel M. Chartrain , Guy H. Harris , Jennifer Nielsen-Kahn , Brian Heimbuch
发明人： Michael G. Sturr , Michel M. Chartrain , Guy H. Harris , Jennifer Nielsen-Kahn , Brian Heimbuch
IPC分类号： C12P1944
CPC分类号： C07D309/10
摘要： 11-hydroxysordarin, biotransformation product of a fermentation with sordarin and Actinomyces spp., (Merck Culture Collection MA7235) ATCC No. 202103 is an antifungal agent. This compound may be useful in the treatment of diseases caused by fungal pathogens such as Candida albicans.
摘要翻译： 11-羟基ys arin素，发酵与sordarin和放线菌属（Merck Culture Collection MA7235）ATCC No. 202103的生物转化产物是抗真菌剂。 该化合物可用于治疗由真菌病原体如白色念珠菌引起的疾病。
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公开(公告)号：US6096511A
公开(公告)日：2000-08-01
申请号：US89307
申请日：1998-06-02
摘要： Inhibition of protein elongation factor 2 provides a target for identifying potential antifungal and antiparasitic compounds. EF2 inhibitors are useful as therapeutic agents against fungal and parasitic infections.
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公开(公告)号：US5972996A
公开(公告)日：1999-10-26
申请号：US123230
申请日：1998-07-28
申请人： Jennifer Nielsen-Kahn , Bruce Tse
发明人： Jennifer Nielsen-Kahn , Bruce Tse
IPC分类号： C07H15/24 , A61K31/35 , A61K31/36 , C07D309/10 , C07D311/94
CPC分类号： C07H15/24
摘要： 4-Cyano-4-deformylsordarin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops.
摘要翻译： 4-氰基-4-去甲基吗啉衍生物是可用于治疗和/或预防人和动物真菌感染以及控制作物中植物病原真菌的抗真菌剂。
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