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    SERS Nanotag Assays
    2.
    发明申请
    SERS Nanotag Assays 审中-公开
    SERS Nanotag测定

    公开(公告)号：US20120164624A1

    公开(公告)日：2012-06-28

    申请号：US12184691

    申请日：2008-08-01

    申请人： Michael J. Natan ,  Sharron Gaynor Penn ,  Remy Cromer ,  Michael Sha

    发明人： Michael J. Natan ,  Sharron Gaynor Penn ,  Remy Cromer ,  Michael Sha

    IPC分类号： G01N21/65 ,  B82Y15/00

    CPC分类号： G01N21/658 ,  B82Y5/00 ,  C12Q1/6816 ,  G01N33/54373 ,  Y10T436/143333 ,  C12Q2537/125 ,  C12Q2563/131 ,  C12Q2563/143 ,  C12Q2565/632

    摘要： Methods and systems for the use of Surface Enhanced Raman Scattering nanotags (SERS nanotags) to create homogeneous (no-wash), heterogeneous or sequence detection assay platforms. In certain embodiments the SERS nanotags are used in combination with magnetic particles. Multiplexed assay platforms are also disclosed. In certain embodiments, the assay is useful for clinical proteomics. Assay platforms suitable for use within a biological matrix, for example within whole blood or serum are also disclosed. The assay formats described herein may be used to detect any analyte of interest including but not limited to the detection of cells, viruses, bacteria, proteins, DNA, RNA, or small molecules in any type of biological (animal or plant kingdom) or environmental samples including but not limited to whole blood or serum, occult samples, urine, feces, air, drinking water, phage, any organism, multicellular clumps of cells, for example, cancer tissue homogenate.

    摘要翻译： 使用表面增强拉曼散射纳米标签（SERS纳米标签）的方法和系统，以创建均质（非洗涤），异质或序列检测测定平台。 在某些实施方案中，SERS纳米颗粒与磁性颗粒结合使用。 还公开了多重测定平台。 在某些实施方案中，该测定可用于临床蛋白质组学。 还公开了适用于生物基质，例如全血或血清中的测定平台。 本文描述的测定形式可用于检测感兴趣的任何分析物，包括但不限于检测任何类型的生物（动物或植物界）或环境中的细胞，病毒，细菌，蛋白质，DNA，RNA或小分子 样品包括但不限于全血或血清，隐匿样品，尿液，粪便，空气，饮用水，噬菌体，任何生物，细胞多细胞团，例如癌组织匀浆。

    Method and apparatus for shared subscription-based shipping
    3.
    发明授权
    Method and apparatus for shared subscription-based shipping 有权
    用于基于共享订阅的运输的方法和装置

    公开(公告)号：US07590564B1

    公开(公告)日：2009-09-15

    申请号：US11170917

    申请日：2005-06-30

    申请人： Charles L. Ward ,  Vijay Ravindran ,  David I. Gellman ,  Jeffrey A. Holden ,  Nanyan Nicholls ,  Michael Sha ,  Jeffrey P. Bezos

    发明人： Charles L. Ward ,  Vijay Ravindran ,  David I. Gellman ,  Jeffrey A. Holden ,  Nanyan Nicholls ,  Michael Sha ,  Jeffrey P. Bezos

    IPC分类号： G06Q30/00

    CPC分类号： G06Q30/0603 ,  G06Q10/08 ,  G06Q30/0601 ,  G06Q30/0635

    摘要： Computer-accessible medium and apparatus for providing subscription-based shipping of items. Embodiments may provide mechanisms that allow customers of an e-commerce Web site to pay a fee to obtain a subscription in a shipping program that provides subscribed customers with free and/or reduced-rate shipping for at least some items ordered via the e-commerce Web site during the period covered by the subscription. The Web site may provide user interface elements on the Web site that may provide one or more shipping and possibly other options only to subscribed customers. Some embodiments may provide mechanisms that allow a subscriber to share a subscription to the shipping program with other customers. One embodiment may provide a mechanism through which a subscribed customer can invite other customers to share a subscription. Some embodiments may provide other exclusive services and/or offers to the subscribers of the shipping program that are not provided or offered to non-subscribers.

    摘要翻译： 计算机可访问介质和用于提供基于订阅的物品运输的设备。 实施例可以提供允许电子商务网站的客户支付费用以获得在运送程序中的订阅的机制，该运送程序为订阅的客户提供至少一些通过电子商务订购的项目的免费和/或降价运送 订阅期间的网站。 该网站可以在网站上提供用户界面元素，其可以仅向订阅的客户提供一个或多个运送和可能的其它选项。 一些实施例可以提供允许订户与其他客户共享对运送程序的订阅的机制。 一个实施例可以提供订阅的客户可以通过该机制邀请其他客户共享订阅的机制。 一些实施例可以向未向非订户提供或提供的运送程序的订户提供其他独家服务和/或优惠。

    Method and apparatus for subscription-based shipping
    5.
    发明授权
    Method and apparatus for subscription-based shipping 有权
    用于基于订阅的运输的方法和装置

    公开(公告)号：US07590565B2

    公开(公告)日：2009-09-15

    申请号：US11170941

    申请日：2005-06-30

    申请人： Charles L. Ward ,  Vijay Ravindran ,  David I. Gellman ,  Jeffrey A. Holden ,  Nanyan Nicholls ,  Michael Sha ,  Jeffrey P. Bezos

    发明人： Charles L. Ward ,  Vijay Ravindran ,  David I. Gellman ,  Jeffrey A. Holden ,  Nanyan Nicholls ,  Michael Sha ,  Jeffrey P. Bezos

    IPC分类号： G06Q30/00

    CPC分类号： G06Q10/08 ,  G06Q30/06 ,  G06Q30/0633

    摘要： Computer-accessible medium and apparatus for providing subscription-based shipping of items. Embodiments may provide mechanisms that allow customers of an e-commerce Web site to pay a fee to obtain a subscription in a shipping program that provides subscribed customers with free and/or reduced-rate shipping for at least some items ordered via the e-commerce Web site during the period covered by the subscription. The Web site may provide user interface elements on the Web site that may provide one or more shipping and possibly other options only to subscribed customers. Some embodiments may provide mechanisms that allow a subscriber to share a subscription to the shipping program with other customers. One embodiment may provide a mechanism through which a subscribed customer can invite other customers to share a subscription. Some embodiments may provide other exclusive services and/or offers to the subscribers of the shipping program that are not provided or offered to non-subscribers.

    摘要翻译： 计算机可访问介质和用于提供基于订阅的物品运输的设备。 实施例可以提供允许电子商务网站的客户支付费用以获得在运送程序中的订阅的机制，该运送程序向订阅的客户提供至少一些通过电子商务订购的项目的免费和/或降价运送 订阅期间的网站。 该网站可以在网站上提供用户界面元素，其可以仅向订阅的客户提供一个或多个运送和可能的其它选项。 一些实施例可以提供允许订户与其他客户共享对运送程序的订阅的机制。 一个实施例可以提供订阅的客户可以通过该机制邀请其他客户共享订阅的机制。 一些实施例可以向未向非订户提供或提供的运送程序的订户提供其他独家服务和/或优惠。