公开(公告)号：US06342635B1

公开(公告)日：2002-01-29

申请号：US09257532

申请日：1999-02-25

申请人： Michael J. Virnig ,  Horst Josten ,  Mary Collins ,  George Wolfe ,  Dustin Gordon ,  Rainer Eskuchen ,  Eugen Heinrichs ,  Frank McDonnell ,  Paul O'Driscoll

发明人： Michael J. Virnig ,  Horst Josten ,  Mary Collins ,  George Wolfe ,  Dustin Gordon ,  Rainer Eskuchen ,  Eugen Heinrichs ,  Frank McDonnell ,  Paul O'Driscoll

IPC分类号： C07C24908

CPC分类号： C07C249/08 ,  C07C45/54 ,  C07C49/825 ,  C07C251/48

摘要： Ketoximes, processes for their preparation, compositions containing them, and a copper extraction process using the compositions. One process for the preparation of the ketoximes comprises the following steps: A) reacting a phenol with a monocarboxylic acid, monocarboxylic acid halide, or monocarboxylic acid anhydride in an inert organic solvent in the presence of an acid catalyst to esterify the phenol; B) removing any water of reaction produced in step A) either during step A) or in a separate step following step A); C) adding a Lewis acid to the resulting anhydrous reaction mixture; D) heating the reaction mixture from step C) to a reaction temperature sufficient to obtain a ketone by the Fries Rearrangement; E) maintaining the heated reaction mixture for a time period of from 2 to 8 hours at the reaction temperature; F) at a time of from half to three-quarters of said time period, adding to the heated reaction mixture additional aliphatic monocarboxylic acid, acid halide, or acid anhydride, optionally with additional Lewis acid, and continuing to maintain the heated reaction mixture at the reaction temperature for the remainder of said time period; G) isolating the ketone reaction product from the reaction mixture; and H) reacting hydroxylamine or a salt thereof with the ketone obtained in step G) to produce a ketoxime from said ketone.

摘要翻译： 酮肟，其制备方法，含有它们的组合物和使用该组合物的铜提取方法。制备酮肟的一种方法包括以下步骤：A）使苯酚与单羧酸，单羧酸卤化物或一元羧酸 酸酐在酸催化剂存在下在惰性有机溶剂中反应以酯化酚; B）在步骤A）期间或在步骤A）之后的单独步骤中除去步骤A）中产生的任何反应水; C）加入路易斯 酸至所得无水反应混合物; D）将来自步骤C）的反应混合物加热至足以通过Fries重新排列获得酮的反应温度; E）将加热的反应混合物保持2至8小时的时间段 反应温度; F）在所述时间段的一半至四分之三的时间内，向加热的反应混合物中加入另外的脂族单羧酸，酰卤或酸酐 e，任选地与另外的路易斯酸反应，并在所述时间段的剩余时间内继续将加热的反应混合物保持在反应温度; G）从反应混合物中分离酮反应产物; 和H）使羟胺或其盐与步骤G）中获得的酮反应，以从所述酮产生酮肟。