公开(公告)号：US06342635B1

公开(公告)日：2002-01-29

申请号：US09257532

申请日：1999-02-25

申请人： Michael J. Virnig ,  Horst Josten ,  Mary Collins ,  George Wolfe ,  Dustin Gordon ,  Rainer Eskuchen ,  Eugen Heinrichs ,  Frank McDonnell ,  Paul O'Driscoll

发明人： Michael J. Virnig ,  Horst Josten ,  Mary Collins ,  George Wolfe ,  Dustin Gordon ,  Rainer Eskuchen ,  Eugen Heinrichs ,  Frank McDonnell ,  Paul O'Driscoll

IPC分类号： C07C24908

CPC分类号： C07C249/08 ,  C07C45/54 ,  C07C49/825 ,  C07C251/48

摘要： Ketoximes, processes for their preparation, compositions containing them, and a copper extraction process using the compositions. One process for the preparation of the ketoximes comprises the following steps: A) reacting a phenol with a monocarboxylic acid, monocarboxylic acid halide, or monocarboxylic acid anhydride in an inert organic solvent in the presence of an acid catalyst to esterify the phenol; B) removing any water of reaction produced in step A) either during step A) or in a separate step following step A); C) adding a Lewis acid to the resulting anhydrous reaction mixture; D) heating the reaction mixture from step C) to a reaction temperature sufficient to obtain a ketone by the Fries Rearrangement; E) maintaining the heated reaction mixture for a time period of from 2 to 8 hours at the reaction temperature; F) at a time of from half to three-quarters of said time period, adding to the heated reaction mixture additional aliphatic monocarboxylic acid, acid halide, or acid anhydride, optionally with additional Lewis acid, and continuing to maintain the heated reaction mixture at the reaction temperature for the remainder of said time period; G) isolating the ketone reaction product from the reaction mixture; and H) reacting hydroxylamine or a salt thereof with the ketone obtained in step G) to produce a ketoxime from said ketone.

摘要翻译： 酮肟，其制备方法，含有它们的组合物和使用该组合物的铜提取方法。制备酮肟的一种方法包括以下步骤：A）使苯酚与单羧酸，单羧酸卤化物或一元羧酸 酸酐在酸催化剂存在下在惰性有机溶剂中反应以酯化酚; B）在步骤A）期间或在步骤A）之后的单独步骤中除去步骤A）中产生的任何反应水; C）加入路易斯 酸至所得无水反应混合物; D）将来自步骤C）的反应混合物加热至足以通过Fries重新排列获得酮的反应温度; E）将加热的反应混合物保持2至8小时的时间段 反应温度; F）在所述时间段的一半至四分之三的时间内，向加热的反应混合物中加入另外的脂族单羧酸，酰卤或酸酐 e，任选地与另外的路易斯酸反应，并在所述时间段的剩余时间内继续将加热的反应混合物保持在反应温度; G）从反应混合物中分离酮反应产物; 和H）使羟胺或其盐与步骤G）中获得的酮反应，以从所述酮产生酮肟。

公开(公告)号：US06639108B2

公开(公告)日：2003-10-28

申请号：US10232371

申请日：2002-09-03

申请人： Thomas Schiffer ,  Peter Ernst Esser ,  Martin Roos ,  Franz-Felix Kuppinger ,  Günter Stevermüer ,  Georg Friedrich Thiele

发明人： Thomas Schiffer ,  Peter Ernst Esser ,  Martin Roos ,  Franz-Felix Kuppinger ,  Günter Stevermüer ,  Georg Friedrich Thiele

IPC分类号： C07C24908

CPC分类号： B01D61/362 ,  C07C249/08 ,  C07C249/14 ,  C07C2601/18 ,  C07C2601/20 ,  C07C251/44 ,  C07C251/48

摘要： A process for the work-up of a reaction mixture formed by ammoximation of a ketone, in particular an alkanone or cycloalkanone, by means of hydrogen peroxide and ammonia in homogeneous solution over a titanium-containing catalyst. It comprises the substeps removal of the catalyst, selective separation of the oxime formed in the ammoximation from the reaction mixture, removal of water of reaction and recirculation of the solvent. The work-up is carried out using at least one membrane separation step and is also successful in the case of incomplete ketone conversion and in the presence of dissolved salts.

摘要翻译： 通过在含钛催化剂上的均相溶液中通过过氧化氢和氨将酮特别是烷酮或环烷酮氨基肟化形成的反应混合物的处理方法。 它包括除去催化剂的子步骤，从反应混合物中形成的肟肟的选择性分离，去除反应水和溶剂的再循环。 使用至少一个膜分离步骤进行后处理，并且在不完全的酮转化和在溶解的盐的存在下也是成功的。

公开(公告)号：US06620970B2

公开(公告)日：2003-09-16

申请号：US10232569

申请日：2002-09-03

申请人： Thomas Schiffer ,  Peter Ernst Esser ,  Jörg Krissmann ,  Martin Roos ,  Günter Stevermüer ,  Georg Friedrich Thiele

发明人： Thomas Schiffer ,  Peter Ernst Esser ,  Jörg Krissmann ,  Martin Roos ,  Günter Stevermüer ,  Georg Friedrich Thiele

IPC分类号： C07C24908

CPC分类号： C07C249/14 ,  C07C2601/18 ,  C07C2601/20 ,  C07C251/44

摘要： The present invention relates to a process for working up an ammoximation reaction mixture, by separating a catalyst from the reaction mixture, removing the ketone oxime product, discharging the water of the reaction, and recirculating a solvent, where the ketone oxime formed is removed in a liquid phase with at least one liquid-liquid extraction in a ternary solvent system.

公开(公告)号：US06759556B2

公开(公告)日：2004-07-06

申请号：US10297181

申请日：2003-08-28

申请人： Marc Blaauw ,  Theodorus Friederich Maria Riesthuis ,  Alex Pit ,  Henk Oevering ,  Antonius Jacobus Franciscus Simons

发明人： Marc Blaauw ,  Theodorus Friederich Maria Riesthuis ,  Alex Pit ,  Henk Oevering ,  Antonius Jacobus Franciscus Simons

IPC分类号： C07C24908

CPC分类号： C07C249/08 ,  C01B21/1418 ,  C07C2601/14 ,  C07C251/44

摘要： Process for the production of cyclohexanone oxime in which a phosphate-containing aqueous reaction medium is cycled from a hydroxylammonium synthesis zone to a cyclohexanone oxime synthesis zone and back to the hydroxylammonium synthesis zone, in which hydroxylammonium synthesis zone hydroxylammonium is formed by catalytic reduction of nitrate with hydrogen, and in which cyclohexanone oxime synthesis zone hydroxylammonium is reacted with cyclohexanone to form cyclohexanone oxime, wherein the phosphate concentration in the acqueous reaction medium entering the cyclohexanone oxime synthesis zone is higher than 3.0 mol/l.

摘要翻译： 制备环己酮肟的方法，其中含磷酸盐的水性反应介质从羟基铵合成区循环到环己酮肟合成区并返回到羟基铵合成区，其中通过催化还原硝酸盐形成羟基铵合成区羟基铵 其中环己酮肟合成区羟基铵与环己酮反应形成环己酮肟，其中进入环己酮肟合成区的水性反应介质中的磷酸盐浓度高于3.0mol / l。

公开(公告)号：US06288276B1

公开(公告)日：2001-09-11

申请号：US09561667

申请日：2000-05-02

申请人： Jeffrey H. Dimmit ,  Mark A. Kearns ,  William H. Chambless

发明人： Jeffrey H. Dimmit ,  Mark A. Kearns ,  William H. Chambless

IPC分类号： C07C24908

CPC分类号： C07C45/68

摘要： Process for making Oximes of the formula IV wherein each of R2-R5 is hydrogen, a halogen, an alkyl or cycloalkyl group having from 1 to 36 carbon atoms, an aryl or alkaryl group having from 1 to 36 carbon atoms, an alkoxy or an aryloxy group having from 1 to 30 carbon atoms, an acyl group having from 1 to 24 carbon atoms and intermediates leading thereto are described.

摘要翻译： 制备式IV化合物的方法，其中R2-R5各自为氢，卤素，具有1至36个碳原子的烷基或环烷基，具有1至36个碳原子的芳基或烷芳基，烷氧基或芳氧基 描述了具有1至30个碳原子的基团，具有1至24个碳原子的酰基和通向其的中间体。