-
1.发明授权公开(公告)号：US07125872B2
公开(公告)日：2006-10-24
申请号：US10745471
申请日：2003-12-22
IPC分类号： A01N43/58
CPC分类号： C07K7/06 , A61K31/4035 , A61K31/4152 , A61K31/437 , A61K31/5025 , C07D471/04 , C07D487/04 , C07D513/04 , C07K1/047 , C07K5/0202 , C07K5/021 , C07K5/06139 , C07K5/06191 , C07K5/0821 , C07K5/1024
摘要： There are disclosed β-sheet mimetics and methods relating to the same for imparting or stabilizing the β-sheet structure of a peptide, protein or molecule. In one aspect, β-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the β-sheet mimetic is a thrombin inhibitor.
-
2.发明授权&bgr;-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins 失效β-折叠模拟物及其作为生物活性肽或蛋白质抑制剂的用途公开(公告)号：US06245764B1
公开(公告)日：2001-06-12
申请号：US09009665
申请日：1998-01-20
IPC分类号： A01N4358
CPC分类号： C07K7/06 , A61K31/4035 , A61K31/4152 , A61K31/437 , A61K31/5025 , A61K38/005 , A61K38/04 , A61K38/55 , C07K1/047 , C07K5/0202 , C07K5/021 , C07K5/06139 , C07K5/06191 , C07K5/0821 , C07K5/1024
摘要： There are disclosed &bgr;-sheet mimetics and methods relating to the same for imparting or stabilizing the &bgr;-sheet structure of a peptide, protein or molecule. In one aspect, &bgr;-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the &bgr;-sheet mimetic is a thrombin inhibitor.
摘要翻译： 公开了与赋予或稳定肽，蛋白质或分子的β-折叠结构相关的β-折叠模拟物和方法。 一方面，公开了通常用作蛋白酶抑制剂的β-片剂模拟物，更具体地，作为丝氨酸蛋白酶抑制剂如凝血酶，弹性蛋白酶和因子X抑制剂。 在一个实施方案中，β-折叠模拟物是凝血酶抑制剂。
-
3.发明授权&bgr;-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins 失效β-折叠模拟物及其作为生物活性肽或蛋白质抑制剂的用途公开(公告)号：US06699869B1
公开(公告)日：2004-03-02
申请号：US09561107
申请日：2000-04-28
IPC分类号： A01N4358
CPC分类号： C07K7/06 , A61K31/4035 , A61K31/4152 , A61K31/437 , A61K31/5025 , C07D471/04 , C07D487/04 , C07D513/04 , C07K1/047 , C07K5/0202 , C07K5/021 , C07K5/06139 , C07K5/06191 , C07K5/0821 , C07K5/1024
摘要： There are disclosed &bgr;-sheet mimetics and methods relating to the same for imparting or stabilizing the &bgr;-sheet structure of a peptide, protein or molecule. In one aspect, &bgr;-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the &bgr;-sheet mimetic is a thrombin inhibitor.
摘要翻译： 公开了与赋予或稳定肽，蛋白质或分子的β-折叠结构相关的β-折叠模拟物和方法。 一方面，公开了通常用作蛋白酶抑制剂的β-片剂模拟物，更具体地，作为丝氨酸蛋白酶抑制剂如凝血酶，弹性蛋白酶和因子X抑制剂。 在一个实施方案中，β-折叠模拟物是凝血酶抑制剂。
-
4.发明授权β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins 失效β-折叠模拟物及其作为生物活性肽或蛋白质抑制剂的用途公开(公告)号：US07511039B2
公开(公告)日：2009-03-31
申请号：US11448412
申请日：2006-06-07
IPC分类号： A01N43/58
CPC分类号： C07K7/06 , A61K31/4035 , A61K31/4152 , A61K31/437 , A61K31/5025 , C07D471/04 , C07D487/04 , C07D513/04 , C07K1/047 , C07K5/0202 , C07K5/021 , C07K5/06139 , C07K5/06191 , C07K5/0821 , C07K5/1024
摘要： There are disclosed β-sheet mimetics and methods relating to the same for imparting or stabilizing the β-sheet structure of a peptide, protein or molecule. In one aspect, β-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the β-sheet mimetic is a thrombin inhibitor.
摘要翻译： 公开了与赋予或稳定肽，蛋白质或分子的β-折叠结构相关的β-折叠模拟物和方法。 一方面，公开了通常用作蛋白酶抑制剂的β-片剂模拟物，更具体地，作为丝氨酸蛋白酶抑制剂如凝血酶，弹性蛋白酶和因子X抑制剂。 在一个实施方案中，β-折叠模拟物是凝血酶抑制剂。
-
公开(公告)号：US07598253B2
公开(公告)日：2009-10-06
申请号：US10360549
申请日：2003-02-07
申请人： Michael Kahn , Masakatsu Eguchi , Hwa-Ok Kim , Marcin Stasiak
发明人： Michael Kahn , Masakatsu Eguchi , Hwa-Ok Kim , Marcin Stasiak
IPC分类号： A61K31/519 , A61K31/495 , A61K31/33
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/519 , A61K31/551 , A61K38/00 , C07K5/0202 , C07K5/0205 , C07K5/06139 , C40B40/00 , Y10S514/825 , Y10S514/826 , Y10S514/903
摘要： Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, such as multiple sclerosis, atherosclerosis, asthma and inflammatory bowel disease.
-
公开(公告)号：US06184223B2
公开(公告)日：2001-02-06
申请号：US09344221
申请日：1999-06-25
申请人： Michael Kahn , Masakatsu Eguchi , Hwa-Ok Kim , Marcin Stasiak
发明人： Michael Kahn , Masakatsu Eguchi , Hwa-Ok Kim , Marcin Stasiak
IPC分类号： A61K314985
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/519 , A61K31/551 , A61K38/00 , C07K5/0202 , C07K5/0205 , C07K5/06139 , C40B40/00 , Y10S514/825 , Y10S514/826 , Y10S514/903
摘要： Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, such as multiple sclerosis, atherosclerosis, asthma and inflammatory bowel disease.
摘要翻译： 公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。 这种逆转模拟物可用于治疗细胞粘附指示疾病，例如多发性硬化，动脉粥样硬化，哮喘和炎症性肠病。
-
公开(公告)号：US06413963B2
公开(公告)日：2002-07-02
申请号：US09742682
申请日：2000-12-19
申请人： Michael Kahn , Masakatsu Eguchi , Hwa-Ok Kim , Marcin Stasiak
发明人： Michael Kahn , Masakatsu Eguchi , Hwa-Ok Kim , Marcin Stasiak
IPC分类号： A61K314985
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/519 , A61K31/551 , A61K38/00 , C07K5/0202 , C07K5/0205 , C07K5/06139 , C40B40/00 , Y10S514/825 , Y10S514/826 , Y10S514/903
摘要： Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, such as multiple sclerosis, atherosclerosis, asthma and inflammatory bowel disease.
-
公开(公告)号：US6013458A
公开(公告)日：2000-01-11
申请号：US846432
申请日：1997-04-30
申请人： Michael Kahn , Masakatsu Eguchi , Hwa-Ok Kim
发明人： Michael Kahn , Masakatsu Eguchi , Hwa-Ok Kim
IPC分类号： A61K31/00 , A61K31/505 , A61K31/519 , A61K31/551 , A61K31/553 , A61K38/00 , A61P25/04 , A61P43/00 , C07D487/04 , C07D498/04 , C07K5/078 , G01N33/543 , C07D471/00 , C07D487/00
CPC分类号： C07D487/04 , C07K5/06139 , A61K38/00
摘要： Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetics of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.
摘要翻译： 公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。 这种反转模拟物可用于广泛的领域，包括用作诊断和治疗剂。 还公开了包含本发明的逆转模拟物的文库，以及用于筛选该文库以识别生物活性成员的方法。
-
9.发明申请Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins 失效β-β模拟物及其作为生物活性肽或蛋白质抑制剂的用途公开(公告)号：US20060276408A1
公开(公告)日：2006-12-07
申请号：US11448412
申请日：2006-06-07
申请人： Michael Kahn , Cyprian Ogbu , Masakatsu Eguchi , Hwa-Ok Kim , Patrick Boatman
发明人： Michael Kahn , Cyprian Ogbu , Masakatsu Eguchi , Hwa-Ok Kim , Patrick Boatman
IPC分类号： A61K38/05 , A61K38/04 , A61K31/503 , A61K31/4162 , C07D487/04
CPC分类号： C07K7/06 , A61K31/4035 , A61K31/4152 , A61K31/437 , A61K31/5025 , C07D471/04 , C07D487/04 , C07D513/04 , C07K1/047 , C07K5/0202 , C07K5/021 , C07K5/06139 , C07K5/06191 , C07K5/0821 , C07K5/1024
摘要： There are disclosed β-sheet mimetics and methods relating to the same for imparting or stabilizing the β-sheet structure of a peptide, protein or molecule. In one aspect, β-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the β-sheet mimetic is a thrombin inhibitor.
摘要翻译： 公开了与赋予或稳定肽，蛋白质或分子的β-折叠结构相关的β-折叠模拟物和方法。 一方面，公开了通常用作蛋白酶抑制剂的β-片剂模拟物，更具体地，作为丝氨酸蛋白酶抑制剂如凝血酶，弹性蛋白酶和因子X抑制剂。 在一个实施方案中，β-折叠模拟物是凝血酶抑制剂。
-
公开(公告)号：US06548500B2
公开(公告)日：2003-04-15
申请号：US09742680
申请日：2000-12-19
申请人： Michael Kahn , Masakatsu Eguchi , Hwa-Ok Kim , Marcin Stasiak
发明人： Michael Kahn , Masakatsu Eguchi , Hwa-Ok Kim , Marcin Stasiak
IPC分类号： A61K314985
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/519 , A61K31/551 , A61K38/00 , C07K5/0202 , C07K5/0205 , C07K5/06139 , C40B40/00 , Y10S514/825 , Y10S514/826 , Y10S514/903
摘要： Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, such as multiple sclerosis, atherosclerosis, asthma and inflammatory bowel disease.
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.037 秒)
