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公开(公告)号:US5399698A
公开(公告)日:1995-03-21
申请号:US18669
申请日:1993-02-17
申请人: Michael Matzke , Klaus-Helmut Mohrs , Siegfried Raddatz , Romanis Fruchtmann , Armin Hatzelmann , Christian Kohlsdorfer , Reiner Muller-Peddinghaus , Pia Theisen-Popp
发明人: Michael Matzke , Klaus-Helmut Mohrs , Siegfried Raddatz , Romanis Fruchtmann , Armin Hatzelmann , Christian Kohlsdorfer , Reiner Muller-Peddinghaus , Pia Theisen-Popp
IPC分类号: A61K31/47 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D215/16 , C07D215/20 , C07D215/48 , C07D215/06 , C07D215/12
CPC分类号: C07D215/14
摘要: The novel quinolin-2-yl-methoxybenzylhydroxyureas can be prepared by reaction of appropriate ketones with hydroxylamine and reduction of the ketoximes and subsequent reaction with isocyanates. The new substances can be employed as active substances in medicaments.
摘要翻译: 该新型喹啉-2-基 - 甲氧基苄基羟基脲可以通过使适当的酮与羟胺反应并还原酮肟并随后与异氰酸酯反应来制备。 新物质可用作药物中的活性物质。
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2.
公开(公告)号:US5292769A
公开(公告)日:1994-03-08
申请号:US934059
申请日:1992-08-21
申请人: Klaus-Helmut Mohrs , Siegfried Raddatz , Michael Matzke , Romanis Fruchtmann , Armin Hatzelmann , Christian Kohlsdorfer , Reiner Muller-Peddinghaus , Pia Theisen-Popp
发明人: Klaus-Helmut Mohrs , Siegfried Raddatz , Michael Matzke , Romanis Fruchtmann , Armin Hatzelmann , Christian Kohlsdorfer , Reiner Muller-Peddinghaus , Pia Theisen-Popp
IPC分类号: A61K31/47 , A61P7/02 , A61P9/10 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/08 , C07D215/14 , C07D215/20 , C07D215/16
CPC分类号: C07D215/14
摘要: Substituted mandelic acid derivatives can be prepared by reaction of glyoxylic esters with Grignard compounds. The substituted mandelic acid derivatives are suitable as active compounds in medicaments, in particular for medicaments which inhibit leukotriene synthesis.
摘要翻译: 取代的扁桃酸衍生物可以通过乙醛酸酯与格氏化合物的反应来制备。 取代的扁桃酸衍生物适合作为药物中的活性化合物,特别是抑制白三烯合成的药物。
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公开(公告)号:US5266578A
公开(公告)日:1993-11-30
申请号:US936180
申请日:1992-08-26
申请人: Siegfried Raddatz , Klaus-Helmut Mohrs , Michael Matzke , Romanis Fruchtmann , Armin Hatzelmann , Christian Kohlsdorfer , Reiner Muller-Peddinghaus , Pia Theisen-Popp
发明人: Siegfried Raddatz , Klaus-Helmut Mohrs , Michael Matzke , Romanis Fruchtmann , Armin Hatzelmann , Christian Kohlsdorfer , Reiner Muller-Peddinghaus , Pia Theisen-Popp
IPC分类号: A61K31/47 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A01N43/42 , C07C215/38
CPC分类号: C07D401/12 , C07D417/12
摘要: Heterocyclically substituted quinolylmethoxyphenylacetamides are prepared by amidation of corresponding carboxylic acids. The compounds can be used in medicaments, in particular those having lipoxygenase-inhibiting action.
摘要翻译: 通过酰胺化相应的羧酸制备杂环取代的喹啉基甲氧基苯基乙酰胺。 这些化合物可以用于药物,特别是那些具有脂氧合酶抑制作用的化合物。
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公开(公告)号:US5231103A
公开(公告)日:1993-07-27
申请号:US917641
申请日:1992-07-21
申请人: Michael Matzke , Klaus-Helmut Mohrs , Siegfried Raddatz , Romanis Fruchtmann , Armin Hatzelmann , Christian Kohlsdorfer , Reiner Muller-Peddinghaus , Pia Theisen-Popp
发明人: Michael Matzke , Klaus-Helmut Mohrs , Siegfried Raddatz , Romanis Fruchtmann , Armin Hatzelmann , Christian Kohlsdorfer , Reiner Muller-Peddinghaus , Pia Theisen-Popp
IPC分类号: A61K31/47 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D215/16 , C07D215/20 , C07D215/48
CPC分类号: C07D215/14
摘要: The novel quinolin-2-yl-methoxybenzylhydroxyureas can be prepared by reaction of appropriate ketones with hydroxylamine and reduction of the ketoximes and subsequent reaction with isocyanates. The new substances can be employed as active substances in medicaments.
摘要翻译: 该新型喹啉-2-基 - 甲氧基苄基羟基脲可以通过使适当的酮与羟胺反应并还原酮肟并随后与异氰酸酯反应来制备。 新物质可用作药物中的活性物质。
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公开(公告)号:US5304563A
公开(公告)日:1994-04-19
申请号:US967881
申请日:1992-10-28
申请人: Siegfried Raddatz , Klaus-Helmut Mohrs , Michael Matzke , Romanis Fruchtmann , Armin Hatzelmann , Christian Kohlsdorfer , Reiner Muller-Peddinghaus , Pia Theisen-Popp
发明人: Siegfried Raddatz , Klaus-Helmut Mohrs , Michael Matzke , Romanis Fruchtmann , Armin Hatzelmann , Christian Kohlsdorfer , Reiner Muller-Peddinghaus , Pia Theisen-Popp
IPC分类号: C07D215/14 , C07D401/12 , C07D403/06 , A61K31/47 , A61K31/505 , C07D215/48
CPC分类号: C07D401/12 , C07D215/14
摘要: The title compounds are prepared either by reacting the corresponding halogenomethylquinolines with substituted phenols, optionally subsequently alkylating these or hydrolysing esters to acids, or by reacting phenyl-substituted quinolinecarboxylic acid derivatives with sulphonamides. The new phenyl-substituted quinolines are utilizable as active substances in medicaments, in particular as lipoxygenase inhibitors.
摘要翻译: 标题化合物可以通过使相应的卤代甲基喹啉与取代的苯酚反应,任选地将这些或水解酯酸化为酸,或者使苯基取代的喹啉羧酸衍生物与磺酰胺反应来制备。 新的苯基取代的喹啉可用作药物中的活性物质,特别是作为脂氧合酶抑制剂。
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公开(公告)号:US5288733A
公开(公告)日:1994-02-22
申请号:US979756
申请日:1992-11-23
申请人: Siegfried Raddatz , Klaus-Helmut Mohrs , Michael Matzke , Romanis Fruchtmann , Armin Hatzelmann , Reiner Muller-Peddinghaus
发明人: Siegfried Raddatz , Klaus-Helmut Mohrs , Michael Matzke , Romanis Fruchtmann , Armin Hatzelmann , Reiner Muller-Peddinghaus
IPC分类号: A61K31/47 , A61P9/00 , A61P11/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D215/16 , C07D215/48
CPC分类号: C07D215/14
摘要: Quinolylmethoxyphenylacetic acid acylamides and ureas can be prepared either by reacting corresponding carboxylic acids with amides or reacting corresponding amides with isocyanates or ureas. The quinolylmethoxyphenylacetic acid acylamides or ureas can be used as active compounds in medicaments.
摘要翻译: 喹喔啉基甲氧基苯基乙酸酰胺和脲可以通过使相应的羧酸与酰胺反应或使相应的酰胺与异氰酸酯或脲反应来制备。 喹喔啉基甲氧基苯乙酸酰胺或脲可用作药物中的活性化合物。
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7.
公开(公告)号:US5283252A
公开(公告)日:1994-02-01
申请号:US979755
申请日:1992-11-23
申请人: Siegfried Raddatz , Klaus-Helmut Mohrs , Michael Matzke , Romanis Fruchtmann , Armin Hatzelmann , Reiner Muller-Peddinghaus
发明人: Siegfried Raddatz , Klaus-Helmut Mohrs , Michael Matzke , Romanis Fruchtmann , Armin Hatzelmann , Reiner Muller-Peddinghaus
IPC分类号: A61K31/47 , A61P43/00 , C07D215/14 , C07D417/12 , C07D521/00 , C07D417/10 , A61K31/425
CPC分类号: C07D231/12 , C07D215/14 , C07D233/56 , C07D249/08 , C07D417/12
摘要: Thiazolyl-substituted quinolylmethoxyphenylacetic acid derivatives are prepared by reaction of halogenoacetoacetic acid esters with quinolylmethoxyphenylacetic acid thioamides, which are obtainable from corresponding amides with Lawesson's reagent. The substances can be employed in medicaments as inhibitors of enzymatic reactions in the context of arachidonic acid metabolism.
摘要翻译: 噻唑基取代的喹啉基甲氧基苯基乙酸衍生物通过卤代乙酰乙酸酯与喹喔啉基甲氧基苯基乙酸硫代酰胺的反应来制备,可用相应的酰胺与Lawesson's试剂得到。 在花生四烯酸代谢的情况下,这些物质可以用作药物中的酶反应抑制剂。
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公开(公告)号:US5310744A
公开(公告)日:1994-05-10
申请号:US979745
申请日:1992-11-23
申请人: Siegfried Raddatz , Klaus-Helmut Mohrs , Michael Matzke , Romanis Fruchtmann , Armin Hatzelmann , Reiner Muller-Peddinghaus
发明人: Siegfried Raddatz , Klaus-Helmut Mohrs , Michael Matzke , Romanis Fruchtmann , Armin Hatzelmann , Reiner Muller-Peddinghaus
IPC分类号: A61K31/47 , A61K31/495 , A61K31/535 , A61P9/00 , A61P11/00 , A61P37/08 , C07D215/14 , C07D215/16 , C07D215/48
CPC分类号: C07D215/14
摘要: Quinolylmethoxyphenyl-acetamides of the formula: ##STR1## in which A, B, D, E, G, L and M are hydrogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy or optionally substituted aryl;R.sub.1 represents optionally substituted cycloalkyl; andR.sub.2 and R.sub.3 independently represent hydrogen, alkyl, benzyl, or optionally substituted cycloalkyl; or together represent piperidinyl, morpholino, or piperazinyl;show a high in vitro activity as leukotriene synthesis inhibitors and, therefore, are suitable for the treatment and prevention of inflammations.
摘要翻译: 其中A,B,D,E,G,L和M是氢,羟基,卤素,氰基,羧基,硝基,三氟甲基,三氟甲氧基,烷基,烷氧基或任选取代的芳基的下式的醌基甲氧基苯基 - 乙酰胺: R1代表任选取代的环烷基; 并且R 2和R 3独立地表示氢,烷基,苄基或任选取代的环烷基; 或一起代表哌啶基,吗啉代或哌嗪基; 作为白细胞三烯合成抑制剂显示高体外活性,因此适用于治疗和预防炎症。
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9.
公开(公告)号:US5597833A
公开(公告)日:1997-01-28
申请号:US102453
申请日:1993-08-04
申请人: Michael Matzke , Klaus-Helmut Mohrs , Siegfried Raddatz , Romanis Fruchtmann , Reiner M uller-Peddinghaus , Armin Hatzelmann
发明人: Michael Matzke , Klaus-Helmut Mohrs , Siegfried Raddatz , Romanis Fruchtmann , Reiner M uller-Peddinghaus , Armin Hatzelmann
IPC分类号: A61K31/47 , A61P7/02 , A61P29/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D215/16
CPC分类号: C07D215/14
摘要: Substituted quinol-2-yl-methoxy-phenylacetic acid derivatives are prepared by reacting correspondingly substituted phenols with quinolylmethyl halides or by reacting unsubstituted phenols with quinolylmethyl halides and subsequent alkylation. The substituted quinol-2-yl-methoxy-phenylacetic acid derivatives may be employed as active substances in medicaments.
摘要翻译: 取代的喹啉-2-基 - 甲氧基 - 苯乙酸衍生物通过相应地取代的酚与喹啉甲基卤化物反应或通过使未取代的苯酚与喹啉甲基卤化物反应并随后进行烷基化来制备。 取代的喹啉-2-基 - 甲氧基 - 苯乙酸衍生物可用作药物中的活性物质。
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10.
公开(公告)号:US5691337A
公开(公告)日:1997-11-25
申请号:US785146
申请日:1997-01-13
申请人: Ulrich Muller , Richard Connell , Siegfried Goldmann , Klaus-Helmut Mohrs , Siegfried Raddatz , Michael Matzke , Rudi Grutzmann , Martin Beuck , Stefan Wohlfeil , Hilmar Bischoff , Dirk Denzer
发明人: Ulrich Muller , Richard Connell , Siegfried Goldmann , Klaus-Helmut Mohrs , Siegfried Raddatz , Michael Matzke , Rudi Grutzmann , Martin Beuck , Stefan Wohlfeil , Hilmar Bischoff , Dirk Denzer
IPC分类号: A61K31/165 , A61K31/38 , A61K31/381 , A61K31/47 , A61K31/472 , A61K31/495 , A61P9/08 , A61P9/10 , C07C231/02 , C07C235/34 , C07D215/14 , C07D215/18 , C07D215/26 , C07D217/16 , C07D241/42 , C07D333/56 , C07D401/12 , C07D405/12 , C07F7/10 , C07D217/00
CPC分类号: C07D401/12 , C07C235/34 , C07D215/14 , C07D215/18 , C07D215/26 , C07D241/42 , C07D333/56 , C07D405/12
摘要: Oxy-phenyl-(phenyl)glycinolamides with heterocyclic substituents are prepared by reaction of the corresponding oxyphenylcarboxylic acids with heterocyclic substituents with phenylglycinol. The new substances are suitable as active compounds in medicaments, in particular in agents having an antiatherosclerotic action.
摘要翻译: 具有杂环取代基的羟基 - 苯基 - (苯基)甘氨酰胺通过相应的氧基苯基羧酸与杂环取代基与苯基甘氨醇的反应来制备。 这些新物质适合作为药物中的活性化合物,特别是具有抗动脉粥样硬化作用的药物。
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