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公开(公告)号：US07776872B2
公开(公告)日：2010-08-17
申请号：US11510015
申请日：2006-08-25
IPC分类号： C07D239/48 , C07D401/12 , A61K31/506
CPC分类号： C07D401/12 , C07D239/48 , C07D471/04
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein A, D, E, G, J, X, Y, Z R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
摘要翻译： 式I化合物或其药学上可接受的盐，其中A，D，E，G，J，X，Y，Z R6，R7和R8如本文所定义。 还提供了使用该化合物治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的方法和制备该化合物的方法。
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公开(公告)号：US08846705B2
公开(公告)日：2014-09-30
申请号：US12963413
申请日：2010-12-08
申请人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Ronald Charles Hawley , Alam Jahangir , Clara Jeou Jen Lin , Daniel Warren Parish
发明人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Ronald Charles Hawley , Alam Jahangir , Clara Jeou Jen Lin , Daniel Warren Parish
IPC分类号： A61K31/505 , A61K31/506 , C07D239/48 , C07D403/12
CPC分类号： C07D239/49 , A61K31/505 , A61K31/506 , C07D239/48 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的化合物和方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物或其药学上可接受的盐，溶剂合物或 其前体药物，其中D，X，Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。
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公开(公告)号：US07799796B2
公开(公告)日：2010-09-21
申请号：US11509890
申请日：2006-08-25
IPC分类号： C07D239/48 , C07D413/12 , A61K31/506
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the compounds being of formula (I): wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的化合物和方法，所述化合物为式（I）：其中D，X，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8为 如本文所定义。
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公开(公告)号：US07531547B2
公开(公告)日：2009-05-12
申请号：US11510216
申请日：2006-08-25
IPC分类号： C07D239/48 , C07D239/50 , A61K31/505 , A61P11/06
CPC分类号： C07D239/48
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的化合物和方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物：其中D，X，R 1，R 2 ，R3，R4，R5，R6，R7和R8如本文所定义。
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公开(公告)号：US20080207655A1
公开(公告)日：2008-08-28
申请号：US12072664
申请日：2008-02-27
IPC分类号： A61K31/513 , C07D239/48 , A61P13/02 , A61P25/00 , A61P11/00 , A61P1/00
CPC分类号： C07D239/48
摘要： Compounds of formula (I): wherein R1 and R2 are as defined herein. Also disclosed are methods of making and using the subject compounds.
摘要翻译： 式（I）化合物：其中R 1和R 2如本文所定义。 还公开了制备和使用本发明化合物的方法。
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公开(公告)号：US20080207619A1
公开(公告)日：2008-08-28
申请号：US12072663
申请日：2008-02-27
IPC分类号： A61K31/5377 , C07D239/48 , A61K31/513 , A61P11/00 , A61P13/10 , A61P31/04 , A61P31/12 , A61P25/00 , A61P13/00 , A61P1/00 , C07D413/12
CPC分类号： C07D413/12 , C07D239/46 , C07D239/48 , C07D403/12
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the compounds being of formula (I): wherein R1, R2, R3 and R4 are as defined herein.
摘要翻译： 用于治疗由P2X 3和/或P2X 2/3受体拮抗剂介导的疾病的化合物和方法，所述式（I）的化合物：其中R R 1，R 2，R 3和R 4如本文所定义。
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7.发明授权Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases 有权使用二氨基嘧啶P2X3和P2X2 / 3受体调节剂治疗呼吸道和胃肠道疾病的方法公开(公告)号：US08008313B2
公开(公告)日：2011-08-30
申请号：US11509921
申请日：2006-08-25
申请人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Anthony P. D. W. Ford , Ronald Charles Hawley , Alam Jahangir , Amy Geraldine Moore , Daniel Warren Parish
发明人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Anthony P. D. W. Ford , Ronald Charles Hawley , Alam Jahangir , Amy Geraldine Moore , Daniel Warren Parish
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/538 , Y10S514/826
摘要： Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的呼吸道和胃肠道疾病的方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物或其药学上可接受的盐， 其中D，X，Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。
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公开(公告)号：US07858632B2
公开(公告)日：2010-12-28
申请号：US11071555
申请日：2005-03-03
申请人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Ronald Charles Hawley , Alam Jahangir , Clara Jeou Jen Lin , Daniel Warren Parish
发明人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Ronald Charles Hawley , Alam Jahangir , Clara Jeou Jen Lin , Daniel Warren Parish
IPC分类号： C07D239/48 , C07D403/12 , A61K31/505
CPC分类号： C07D239/49 , A61K31/505 , A61K31/506 , C07D239/48 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的化合物和方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物或其药学上可接受的盐，溶剂合物或 其前体药物，其中D，X，Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。
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9.发明授权Methods of using diaminopyrimidine as P2X3 and P2X⅔ receptor modulators for treatment of respiratory and gastrointestinal diseases 有权使用二氨基嘧啶作为P2X3和P2X2 / 3受体调节剂治疗呼吸道和胃肠疾病的方法公开(公告)号：US08524725B2
公开(公告)日：2013-09-03
申请号：US13186078
申请日：2011-07-19
申请人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Anthony P. D. W. Ford , Ronald Charles Hawley , Alam Jahangir , Amy Geraldine Moore , Daniel Warren Parish
发明人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Anthony P. D. W. Ford , Ronald Charles Hawley , Alam Jahangir , Amy Geraldine Moore , Daniel Warren Parish
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/538 , Y10S514/826
摘要： Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的呼吸道和胃肠道疾病的方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物或其药学上可接受的盐， 其中D，X，Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。
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公开(公告)号：US20110077242A1
公开(公告)日：2011-03-31
申请号：US12963413
申请日：2010-12-08
申请人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Ronald Charles Hawley , Alam Jahangir , Clara Jeou Jen Lin , Daniel Warren Parish
发明人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Ronald Charles Hawley , Alam Jahangir , Clara Jeou Jen Lin , Daniel Warren Parish
IPC分类号： A61K31/505 , A61K31/506 , A61K31/538 , A61P29/00 , A61P31/00 , A61P1/00 , A61P9/10 , A61P25/00
CPC分类号： C07D239/49 , A61K31/505 , A61K31/506 , C07D239/48 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的化合物和方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物或其药学上可接受的盐，溶剂合物或 其前体药物，其中D，X，Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。
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