公开(公告)号：US5252575A

公开(公告)日：1993-10-12

申请号：US886710

申请日：1992-05-21

申请人： Michael R. Harnden ,  Paul G. Wyatt ,  Leslie J. A. Jennings

发明人： Michael R. Harnden ,  Paul G. Wyatt ,  Leslie J. A. Jennings

IPC分类号： C07D473/18 ,  C07D473/32 ,  A61K31/52 ,  C07D473/26

CPC分类号： C07D473/32 ,  C07D473/18

摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R.sub.1 is hydrogen or hydroxy; andR.sub.2 is C.sub.1-6 alkyl;which are pro-drugs for 9-(3-hydroxyprop-1-oxy)guanine having antiviral activity, a process for their preparation and their use as pharmaceuticals.

摘要翻译： 式（I）化合物及其药学上可接受的盐：其中R 1是氢或羟基; 和R 2是C 1-6烷基; 其为具有抗病毒活性的9-（3-羟基丙-1-氧）鸟嘌呤的前药，其制备方法及其作为药物的用途。

公开(公告)号：US5108994A

公开(公告)日：1992-04-28

申请号：US528575

申请日：1990-05-23

申请人： Michael R. Harnden ,  Leslie J. A. Jennings

发明人： Michael R. Harnden ,  Leslie J. A. Jennings

IPC分类号： A61K31/675 ,  A61P31/12 ,  A61P35/00 ,  C07F9/165 ,  C07F9/6506 ,  C07F9/6512 ,  C07F9/6561 ,  C07F9/6574

CPC分类号： C07F9/65616

摘要： Compounds of formula (I), and pharmaceutically acceptable salts thereof: ##STR1## wherein R.sub.1 is hydroxy or amino;R.sub.2 is hydrogen or amino;R.sub.3 is hydrogen, hydroxymethyl or acyloxymethyl;R.sub.4 is a group of formula: ##STR2## wherein R.sub.5 and R.sub.6 are independently selected from hydrogen, C.sub.1-6 alkyl and optionally substituted phenyl; orR.sub.3 and R.sub.4 together are: ##STR3## wherein R.sub.6 is as defined above;having antiviral activity, processes for their preparation and their pharmaceutical use.