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公开(公告)号：US06868287B1
公开(公告)日：2005-03-15
申请号：US09505458
申请日：2000-02-11
CPC分类号： A61N1/326 , A61N1/0587 , A61N1/3684
摘要： The invention provides a method of treating a heart to remodel gap junctions, obtain gap junctional remodeling and/or alteration or effective refractory period comprising contacting linked multiple electrode pairs to an epicardial surface of a heart, and connecting the electrode pairs to a pacemaker to apply periodic electrical signals to the epicardial surface through the electrode pairs, the signals being applied for a sufficient time and having characteristics sufficient to remodel gap junctions, obtain gap junctional remodeling and/or alteration of effective refractory period in the heart. The invention also provides a device comprising a strip of electrode material having mounted thereon linked multiple electrode pairs arranged in two columns.
摘要翻译： 本发明提供了一种治疗心脏以重建间隙连接，获得间隙连接重建和/或改变或有效的不应期的方法，包括将连接的多个电极对接触到心脏的心外膜表面，以及将电极对连接到起搏器以施加 通过电极对向心外膜表面施加周期性电信号，信号被施加足够的时间并具有足以改造间隙连接的特征，获得心脏中有效不应期的间隙连接重构和/或改变。 本发明还提供了一种装置，其包括电极材料条，其上安装有连接的多个电极对，其布置成两列。
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2.发明授权Treatment of cardiac arrhythmia by modification of neuronal signaling through fat pads of the heart 有权通过心脏脂肪垫修饰神经元信号来治疗心律失常公开(公告)号：US08401641B2
公开(公告)日：2013-03-19
申请号：US13291082
申请日：2011-11-07
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61K35/33 , A61K38/1825 , A61K38/4893 , A61M5/19 , A61M2039/1083 , A61M2039/1088 , A61M2210/125 , A61N1/3621 , A61N1/395
摘要： To control cardiac arrhythmias such as atrial fibrillation post-operatively, various non-ablative agents include polymers, fibroblasts, neurotoxins, and growth factors are introduced into one or more cardiac fat pads into the atrioventricular nodal fat pad in proximity to the autonomic ganglia therein. Any desired technique may be used for introducing the agent, including injection. The sinoatrial nodal fat pad target site and the atrioventricular nodal fat pad target site are identified using a stimulator, which may have electrodes coupled thereto or which may coupled to electrodes built into a delivery system.
摘要翻译： 为了控制手术后的心律失常，例如心房颤动，各种非消融剂包括聚合物，成纤维细胞，神经毒素和生长因子被引入一个或多个心脏脂肪垫，进入房室结节脂肪垫附近的自主神经节。 可以使用任何所需的技术来引入试剂，包括注射。 使用刺激器识别窦房结脂肪垫靶位点和房室结节脂肪垫靶位点，该刺激器可以具有与其耦合的电极或者可以耦合到内置于递送系统中的电极。
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3.发明申请Treatment of Cardiac Arrhythmia by Modification of Neuronal Signaling Through Fat Pads of the Heart 有权通过心脏脂肪垫修饰神经元信号来治疗心律失常公开(公告)号：US20120053510A1
公开(公告)日：2012-03-01
申请号：US13291082
申请日：2011-11-07
CPC分类号： A61N1/36114 , A61K35/33 , A61K38/1825 , A61K38/4893 , A61M5/19 , A61M2039/1083 , A61M2039/1088 , A61M2210/125 , A61N1/3621 , A61N1/395
摘要： To control cardiac arrhythmias such as atrial fibrillation post-operatively, various non-ablative agents include polymers, fibroblasts, neurotoxins, and growth factors are introduced into one or more cardiac fat pads into the atrioventricular nodal fat pad in proximity to the autonomic ganglia therein. Any desired technique may be used for introducing the agent, including injection. The sinoatrial nodal fat pad target site and the atrioventricular nodal fat pad target site are identified using a stimulator, which may have electrodes coupled thereto or which may coupled to electrodes built into a delivery system.
摘要翻译： 为了控制手术后的心律失常，例如心房颤动，各种非消融剂包括聚合物，成纤维细胞，神经毒素和生长因子被引入一个或多个心脏脂肪垫，进入房室结节脂肪垫附近的自主神经节。 可以使用任何所需的技术来引入试剂，包括注射。 使用刺激器识别窦房结脂肪垫靶位点和房室结节脂肪垫靶位点，该刺激器可以具有与其耦合的电极或者可以耦合到内置于递送系统中的电极。
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4.发明授权Treatment of cardiac arrhythmia by modification of neuronal signaling through fat pads of the heart 有权通过心脏脂肪垫修饰神经元信号来治疗心律失常公开(公告)号：US08073538B2
公开(公告)日：2011-12-06
申请号：US11803673
申请日：2007-05-15
CPC分类号： A61N1/36114 , A61K35/33 , A61K38/1825 , A61K38/4893 , A61M5/19 , A61M2039/1083 , A61M2039/1088 , A61M2210/125 , A61N1/3621 , A61N1/395
摘要： To control cardiac arrhythmias such as atrial fibrillation post-operatively, various non-ablative agents include polymers, fibroblasts, neurotoxins, and growth factors are introduced into one or more cardiac fat pads into the atrioventricular nodal fat pad in proximity to the autonomic ganglia therein. Any desired technique may be used for introducing the agent, including injection. The sinoatrial nodal fat pad target site and the atrioventricular nodal fat pad target site are identified using a stimulator, which may have electrodes coupled thereto or which may coupled to electrodes built into a delivery system.
摘要翻译： 为了控制手术后的心律失常，例如心房颤动，各种非消融剂包括聚合物，成纤维细胞，神经毒素和生长因子被引入一个或多个心脏脂肪垫，进入房室结节脂肪垫附近的自主神经节。 可以使用任何所需的技术来引入试剂，包括注射。 使用刺激器识别窦房结脂肪垫靶位点和房室结节脂肪垫靶位点，该刺激器可以具有与其耦合的电极或者可以耦合到内置于递送系统中的电极。
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