公开(公告)号：US20090169631A1

公开(公告)日：2009-07-02

申请号：US12329318

申请日：2008-12-05

申请人： Michael Zamloot ,  Cherng-chyi Fu ,  De-Hwa Chao ,  Andrei Blasko ,  Su ll Yum

发明人： Michael Zamloot ,  Cherng-chyi Fu ,  De-Hwa Chao ,  Andrei Blasko ,  Su ll Yum

IPC分类号： A61K9/14 ,  A61P25/04

CPC分类号： A61K9/14 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/485

摘要： Novel compositions, formulations and dosage forms comprising stabilized micronized opioid particles are disclosed. Exemplary opioids include oxycodone, oxymorphone, hydrocodone, and hydromorphone, including as free bases or as salts. Stabilized micronized opioid particles having a Dv90 particle size distribution of less and or equal to 10μ or less than or equal to 20μ are disclosed. Methods for micronizing an opioid to provide stabilized micronized opioid particles are also disclosed.

摘要翻译： 公开了包含稳定的微粉化阿片样物质颗粒的新型组合物，制剂和剂型。 示例性阿片样物质包括羟考酮，羟吗啡酮，氢可酮和氢吗啡酮，包括游离碱或盐。 公开了具有小于或等于10mu或小于或等于20mu的Dv90粒度分布的稳定的微粉化阿片样物质颗粒。 还公开了使阿片样物质微粉化以提供稳定的微粉化阿片样物质颗粒的方法。