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1.发明申请METHOD AND APPARATUS FOR NONINVASIVELY MONITORING PARAMETERS OF A REGION OF INTEREST IN A HUMAN BODY 有权一个人体感兴趣区域的非易失性监测参数的方法和装置公开(公告)号：US20120184830A1
公开(公告)日：2012-07-19
申请号：US13356053
申请日：2012-01-23
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/1464 , A61B5/0097 , A61B5/02411 , A61B5/08 , A61B5/14542 , A61B5/7264 , A61B2562/0233 , A61B2562/043 , G01S15/8968
摘要： Apparatus and methods are provided for monitoring a parameter of a region of interest (ROI) within a first tissue type within a body. A control unit drives a measurement unit to provide an operating condition such that acoustic waves overlap with a region within the ROI that is illuminated by illuminating light such as to generate a first set of tagged photons, and such that the acoustic waves overlap with a region of tissue within a second tissue type that is illuminated by illuminating light such as to generate a second set of tagged photons, the first and second sets of tagged photons being distinguishable from one another. The control unit determines the parameter of the ROI by extracting data portions associated with, respectively, the light response of the ROI and the light response of the second tissue type, by distinguishing between the sets of tagged photons.
摘要翻译： 提供了用于监测身体内的第一组织类型内的感兴趣区域（ROI）的参数的装置和方法。 控制单元驱动测量单元以提供操作条件，使得声波与由照明光照射的ROI内的区域重叠，以产生第一组标记光子，并且使得声波与区域重叠 在通过照明光照射的第二组织类型中的组织，以产生第二组标记的光子，所述第一组和第二组标记的光子彼此可区分。 控制单元通过区分两组标记的光子来分别提取与ROI的光响应和第二组织类型的光响应相关联的数据部分来确定ROI的参数。
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2.发明授权Method and apparatus for noninvasively monitoring parameters of a region of interest in a human body 有权用于非侵入性地监测人体感兴趣区域的参数的方法和装置公开(公告)号：US08108022B2
公开(公告)日：2012-01-31
申请号：US11327381
申请日：2006-01-09
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/1464 , A61B5/0097 , A61B5/02411 , A61B5/08 , A61B5/14542 , A61B5/7264 , A61B2562/0233 , A61B2562/043 , G01S15/8968
摘要： Apparatus and methods including a probe device for monitoring a parameter of a region of interest in a human body. A support structure of the device carries an arrangement of light output ports of a light source assembly, light input ports of a light detection assembly, and an acoustic output port of an acoustic unit. The arrangement is such as to enable selection of a light output port, a light input port, and an acoustic output port for an operating condition at which, acoustic waves from the acoustic output port and illuminating light from the light output port overlap in a region within the region of interest in the body thereby inducing tagging of light by the acoustic waves, and the light input port collects light scattered from the overlapping region and light scattered from outside the region of interest. Other embodiments are also described.
摘要翻译： 包括用于监测人体感兴趣区域的参数的探针装置的装置和方法。 该装置的支撑结构携带光源组件的光输出端口，光检测组件的光输入端口和声学单元的声输出端口的布置。 该布置使得能够选择光输出端口，光输入端口和声输出端口，用于来自声输出端口的声波和来自光输出端口的照明光在区域中重叠的操作条件 在体内感兴趣的区域内，由于声波引起光的标记，光输入端口收集从重叠区域散射的光和从感兴趣区域外部散射的光。 还描述了其它实施例。
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3.发明授权Method and apparatus for noninvasively monitoring parameters of a region of interest in a human body 有权用于非侵入性地监测人体感兴趣区域的参数的方法和装置公开(公告)号：US08644900B2
公开(公告)日：2014-02-04
申请号：US13356053
申请日：2012-01-23
IPC分类号： A61B5/1455
CPC分类号： A61B5/1464 , A61B5/0097 , A61B5/02411 , A61B5/08 , A61B5/14542 , A61B5/7264 , A61B2562/0233 , A61B2562/043 , G01S15/8968
摘要： Apparatus and methods are provided for monitoring a parameter of a region of interest (ROI) within a first tissue type within a body. A control unit drives a measurement unit to provide an operating condition such that acoustic waves overlap with a region within the ROI that is illuminated by illuminating light such as to generate a first set of tagged photons, and such that the acoustic waves overlap with a region of tissue within a second tissue type that is illuminated by illuminating light such as to generate a second set of tagged photons, the first and second sets of tagged photons being distinguishable from one another. The control unit determines the parameter of the ROI by extracting data portions associated with, respectively, the light response of the ROI and the light response of the second tissue type, by distinguishing between the sets of tagged photons.
摘要翻译： 提供了用于监测身体内的第一组织类型内的感兴趣区域（ROI）的参数的装置和方法。 控制单元驱动测量单元以提供操作条件，使得声波与由照明光照射的ROI内的区域重叠，以产生第一组标记光子，并且使得声波与区域重叠 在通过照明光照射的第二组织类型中的组织，以产生第二组标记的光子，所述第一组和第二组标记的光子彼此可区分。 控制单元通过区分两组标记的光子来分别提取与ROI的光响应和第二组织类型的光响应相关联的数据部分来确定ROI的参数。
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4.发明申请Method and apparatus for noninvasively monitoring parameters of a region of interest in a human body 有权用于非侵入性地监测人体感兴趣区域的参数的方法和装置公开(公告)号：US20060247506A1
公开(公告)日：2006-11-02
申请号：US10545798
申请日：2004-09-12
IPC分类号： A61B5/00
CPC分类号： A61B5/1464 , A61B5/0097 , A61B5/02411 , A61B5/08 , A61B5/14542 , A61B5/7264 , A61B2562/0233 , A61B2562/043 , G01S15/8968
摘要： A method and system for noninvasive monitoring of at least one parameter of a region of interest in a human body. The system comprises a measurement unit and a control unit. The measurement unit comprises an optical unit having an illumination assembly (101A) and a light detection assembly (101B) to generate measured data indicative of collected light; and an acoustic unit (110) configured to generate acoustic waves of a predetermined ultrasound frequency range. The measurement unit provides an operating condition such that the acoustic waves overlap with an illuminating region within the region of interest and substantially do not overlap outside the region of interest. The measured data is indicative of scattered light having both ultrasound tagged and untagged light portions, enabling to distinguish between light responses of the region of interest and the region outside the region of interest.
摘要翻译： 一种用于对人体内感兴趣区域的至少一个参数进行无创监测的方法和系统。 该系统包括测量单元和控制单元。 测量单元包括具有照明组件（101A）和光检测组件（101B）的光学单元，以产生指示所收集的光的测量数据; 以及被配置为产生预定的超声频率范围的声波的声学单元（110）。 测量单元提供操作条件，使得声波与感兴趣区域内的照明区域重叠，并且基本上不在感兴趣区域外部重叠。 测量数据表示具有超声标记和未标记的光部分的散射光，能够区分感兴趣区域的光响应和感兴趣区域之外的区域。
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5.发明申请Method and apparatus for noninvasively monitoring parameters of a region of interest in a human body 有权用于非侵入性地监测人体感兴趣区域的参数的方法和装置公开(公告)号：US20060122475A1
公开(公告)日：2006-06-08
申请号：US11327381
申请日：2006-01-09
IPC分类号： A61B5/00
CPC分类号： A61B5/1464 , A61B5/0097 , A61B5/02411 , A61B5/08 , A61B5/14542 , A61B5/7264 , A61B2562/0233 , A61B2562/043 , G01S15/8968
摘要： A method and system are presented for use in noninvasive monitoring at least one parameter of a region of interest in a human body. The system comprises a measurement unit and a control unit. The measurement unit comprises an optical unit having an illumination assembly configured to define at least one output port for illuminating light, and a light detection assembly configured to define at least one light input port for collecting light and to generate measured data indicative of the collected light; and an acoustic unit configured to generate acoustic waves of a predetermined ultrasound frequency range. The measurement unit is configured and operable to provide an operating condition such that the acoustic waves of the predetermined frequency range overlap with an illuminating region within the region of interest and substantially do not overlap with a region outside the region of interest, and that the detection assembly collects light scattered from the region of interest and light scattered from the region outside the region of interest. The measured data is thus indicative of scattered light having both ultrasound tagged and untagged light portions, thereby enabling to distinguish between light responses of the region of interest and the region outside the region of interest. The control unit is connectable to the optical unit and to the acoustic unit to operate these units, and is responsive to the measured data and preprogrammed to process and analyze the measured data to extract therefrom data indicative of a light response of the region of interest and determine the at least one desired parameter.
摘要翻译： 提出了一种方法和系统，用于非侵入性监测人体感兴趣区域的至少一个参数。 该系统包括测量单元和控制单元。 测量单元包括光学单元，其具有被配置为限定用于照明光的至少一个输出端口的照明组件;以及光检测组件，其被配置为限定用于收集光的至少一个光输入端口并且产生指示所收集的光的测量数据 ; 以及声学单元，被配置为产生预定的超声频率范围的声波。 测量单元被配置和操作以提供操作条件，使得预定频率范围的声波与感兴趣区域内的照明区域重叠，并且基本上不与感兴趣区域外的区域重叠，并且检测 装配收集从感兴趣区域以外的区域分散的光和从感兴趣区域以外的区域分散的光。 因此，所测量的数据表示具有超声标记和未标记的光部分的散射光，从而能够区分感兴趣区域的光响应和感兴趣区域之外的区域。 控制单元可连接到光学单元和声学单元以操作这些单元，并且响应于测量数据并被预编程以处理和分析测量数据以从其中提取指示感兴趣区域的光响应的数据，以及 确定至少一个期望的参数。
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