公开(公告)号：US08423116B2

公开(公告)日：2013-04-16

申请号：US10593318

申请日：2005-03-16

申请人： Michal Balberg ,  Revital Pery-Shechter ,  Michal Olshansky

发明人： Michal Balberg ,  Revital Pery-Shechter ,  Michal Olshansky

IPC分类号： A61B5/05

CPC分类号： A61B5/1455 ,  A61B5/14546 ,  A61B5/14553 ,  A61B5/7475 ,  A61B8/06 ,  A61B8/0808 ,  A61B8/0816 ,  A61B8/4227 ,  A61B8/4494 ,  A61B2562/0233 ,  A61B2562/043 ,  G01S15/8968

摘要： A measurement system and method are presented for use for non-invasive measurements in a human body. Acoustic radiation is applied to a certain illuminated region in the body, with at least two different conditions of the applied radiation achievable by varying at least one characteristic of the acoustic radiation. Light scattered from the body part is detected, and measured data indicative of detected photons tagged and untagged by the acoustic radiation is generated. The measured data is analyzed to extract therefrom a data portion corresponding to the tagged photons and being therefore associated with a light response of said certain region, thereby enabling determination of tissue properties of said certain region based on a relation between the measured data portions corresponding to the at least two different operating conditions.

摘要翻译： 提出了一种用于人体无创测量的测量系统和方法。 声辐射被施加到身体中的某个照明区域，通过改变声辐射的至少一个特征可以实现所施加辐射的至少两个不同条件。 检测到从身体部分散射的光，并且产生指示被声辐射标记和未标记的检测到的光子的测量数据。 分析测量数据以从其中提取对应于标记的光子的数据部分，并且因此与所述特定区域的光响应相关联，从而可以基于对应于所述特定区域的测量数据部分之间的关​​系来确定所述特定区域的组织属性 至少两个不同的操作条件。

公开(公告)号：US20080194929A1

公开(公告)日：2008-08-14

申请号：US10551543

申请日：2004-03-29

申请人： Benny Pesach ,  Gabriel Bitton ,  Michal Balberg

发明人： Benny Pesach ,  Gabriel Bitton ,  Michal Balberg

IPC分类号： A61B5/1455 ,  A61B8/00

CPC分类号： A61B5/0066 ,  A61B5/0059 ,  A61B5/0095 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/1702 ,  G01N2021/1706

摘要： Apparatus (20, 100) for assaying a target analyte in a localized tissue region (22) that may include the target and other analytes comprising: a light source (34, 104) that illuminates the region with light at each of a plurality of wavelengths at which light is absorbed and/or scattered by tissue in the region wherein light at a least one of the wavelengths is absorbed or scattered by the target analyte; a signal generator (40) that generates signals responsive to intensity of the light from the light source (34, 104) at different locations in the localized region (22); and a controller (32, 102) that: receives the generated signals; processes the signals to determine an extinction coefficient for light in the localized region at each wavelength; and determines the concentration of the target analyte responsive to a solution of a set of simultaneous equations having as unknown variables concentrations of a plurality of analytes in the region (22), one of which is the target analyte, wherein each equation in the set expresses a relationship between the extinction coefficient, the absorption coefficient and/or the reduced scattering coefficient for light at a different one of the plurality of wavelengths and at least one of the equations expresses a relationship between the extinction coefficient and the reduced scattering coefficient.

摘要翻译： 用于测定局部组织区域（22）中可能包括目标物和其它分析物的靶分析物的装置（20,100），包括：光源（34,104），其以多个波长中的每一个的光照射该区域 在该区域中的组织被光吸收和/或散射，其中至少一个波长的光被靶分析物吸收或散射; 信号发生器（40），其在所述局部区域（22）中的不同位置处产生响应于来自所述光源（34,104）的光的强度的信号; 以及控制器（32,102），其接收所生成的信号; 处理信号以确定每个波长处的局部区域中的光的消光系数; 并且确定目标分析物的浓度，其响应于在区域（22）中具有多个分析物浓度的未知变量的一组联立方程（其中一个是目标分析物）的溶液的溶液，其中集合中的每个方程表示 在多个波长中的不同一个波长处的光的消光系数，吸收系数和/或减小的散射系数之间的关系以及至少一个等式表示消光系数和降低的散射系数之间的关系。

公开(公告)号：US20120184830A1

公开(公告)日：2012-07-19

申请号：US13356053

申请日：2012-01-23

申请人： Michal BALBERG ,  Revital Pery-Schechter ,  Michal Olshansky

发明人： Michal BALBERG ,  Revital Pery-Schechter ,  Michal Olshansky

IPC分类号： A61B5/1455 ,  A61B6/00

CPC分类号： A61B5/1464 ,  A61B5/0097 ,  A61B5/02411 ,  A61B5/08 ,  A61B5/14542 ,  A61B5/7264 ,  A61B2562/0233 ,  A61B2562/043 ,  G01S15/8968

摘要： Apparatus and methods are provided for monitoring a parameter of a region of interest (ROI) within a first tissue type within a body. A control unit drives a measurement unit to provide an operating condition such that acoustic waves overlap with a region within the ROI that is illuminated by illuminating light such as to generate a first set of tagged photons, and such that the acoustic waves overlap with a region of tissue within a second tissue type that is illuminated by illuminating light such as to generate a second set of tagged photons, the first and second sets of tagged photons being distinguishable from one another. The control unit determines the parameter of the ROI by extracting data portions associated with, respectively, the light response of the ROI and the light response of the second tissue type, by distinguishing between the sets of tagged photons.

摘要翻译： 提供了用于监测身体内的第一组织类型内的感兴趣区域（ROI）的参数的装置和方法。 控制单元驱动测量单元以提供操作条件，使得声波与由照明光照射的ROI内的区域重叠，以产生第一组标记光子，并且使得声波与区域重叠 在通过照明光照射的第二组织类型中的组织，以产生第二组标记的光子，所述第一组和第二组标记的光子彼此可区分。 控制单元通过区分两组标记的光子来分别提取与ROI的光响应和第二组织类型的光响应相关联的数据部分来确定ROI的参数。

公开(公告)号：US07068867B2

公开(公告)日：2006-06-27

申请号：US10335703

申请日：2003-01-02

申请人： Avner Adoram ,  Benny Pesach ,  Ron Nagar ,  Shai Ashkenazi ,  Michal Balberg

发明人： Avner Adoram ,  Benny Pesach ,  Ron Nagar ,  Shai Ashkenazi ,  Michal Balberg

IPC分类号： G02B6/00

CPC分类号： A61B8/0841 ,  A61B5/0095 ,  A61B5/061 ,  A61B5/6852 ,  A61B8/0833 ,  A61B17/3403 ,  A61B2090/3788

摘要： A system for monitoring a position of an instrument in a subject includes a light transmission medium configured to transmit light pulses to a desired region to produce an acoustic signal, at least one ultrasound sensor configured to receive the acoustic signal and to produce a transduced signal from the acoustic signal, and a processing unit connected to the at least one ultrasound sensor and configured to locate a source of the acoustic signal using the transduced signal.

摘要翻译： 用于监测被检者中的器械的位置的系统包括：光传输介质，被配置为将光脉冲传输到期望的区域以产生声信号;至少一个超声传感器，被配置为接收声信号并产生从 所述声信号以及连接到所述至少一个超声波传感器并被配置为使用所述转导信号来定位所述声信号的源的处理单元。

公开(公告)号：US07515948B1

公开(公告)日：2009-04-07

申请号：US10938880

申请日：2004-09-13

申请人： Michal Balberg ,  Revital Pery Shechter ,  Michal Olshansky

发明人： Michal Balberg ,  Revital Pery Shechter ,  Michal Olshansky

IPC分类号： A61B5/1455

CPC分类号： A61B5/14542 ,  A61B5/0095 ,  A61B5/02411 ,  A61B5/1464 ,  A61B5/7264 ,  A61B7/00

摘要： A method and apparatus are presented for non-invasively monitoring at least one characteristic of a region of interest in a body. The body is illuminated by pulsed light to induce a photoacoustic effect. Acoustic radiation is detected, and measured data indicative thereof is generated. The photoacoustic effect is controlled by carrying out at least one of the following: providing the pulsed light of at least two different wavelength, analyzing the measured data to determine time variations of at least one predetermined parameter of a time dependent acoustic signal for each of wavelength, and determining oxygen saturation level in the region of interest; and operating a plurality of acoustic elements configured for detection of the acoustic radiation, to thereby define a focal volume for acoustic radiation detection to match dimensions of the region of interest.

摘要翻译： 提出了用于非侵入性地监测身体中的感兴趣区域的至少一个特征的方法和装置。 身体被脉冲光照射以引起光声效应。 检测声辐射，产生表示其的测量数据。 通过执行以下至少一个来控​​制光声效应：提供至少两个不同波长的脉冲光，分析测量数据以确定每个波长的时间依赖声学信号的至少一个预定参数的时间变化 并确定感兴趣区域中的氧饱和度水平; 以及操作配置用于检测声辐射的多个声学元件，从而限定用于声辐射检测的焦点体积，以匹配感兴趣区域的尺寸。

公开(公告)号：US20060247506A1

公开(公告)日：2006-11-02

申请号：US10545798

申请日：2004-09-12

申请人： Michal Balberg ,  Revital Pery-Schechter ,  Michal Olshansky

发明人： Michal Balberg ,  Revital Pery-Schechter ,  Michal Olshansky

IPC分类号： A61B5/00

CPC分类号： A61B5/1464 ,  A61B5/0097 ,  A61B5/02411 ,  A61B5/08 ,  A61B5/14542 ,  A61B5/7264 ,  A61B2562/0233 ,  A61B2562/043 ,  G01S15/8968

摘要： A method and system for noninvasive monitoring of at least one parameter of a region of interest in a human body. The system comprises a measurement unit and a control unit. The measurement unit comprises an optical unit having an illumination assembly (101A) and a light detection assembly (101B) to generate measured data indicative of collected light; and an acoustic unit (110) configured to generate acoustic waves of a predetermined ultrasound frequency range. The measurement unit provides an operating condition such that the acoustic waves overlap with an illuminating region within the region of interest and substantially do not overlap outside the region of interest. The measured data is indicative of scattered light having both ultrasound tagged and untagged light portions, enabling to distinguish between light responses of the region of interest and the region outside the region of interest.

摘要翻译： 一种用于对人体内感兴趣区域的至少一个参数进行无创监测的方法和系统。 该系统包括测量单元和控制单元。 测量单元包括具有照明组件（101A）和光检测组件（101B）的光学单元，以产生指示所收集的光的测量数据; 以及被配置为产生预定的超声频率范围的声波的声学单元（110）。 测量单元提供操作条件，使得声波与感兴趣区域内的照明区域重叠，并且基本上不在感兴趣区域外部重叠。 测量数据表示具有超声标记和未标记的光部分的散射光，能够区分感兴趣区域的光响应和感兴趣区域之外的区域。

公开(公告)号：US20060122475A1

公开(公告)日：2006-06-08

申请号：US11327381

申请日：2006-01-09

申请人： Michal Balberg ,  Revital Pery-Schechter ,  Michal Olshansky

发明人： Michal Balberg ,  Revital Pery-Schechter ,  Michal Olshansky

IPC分类号： A61B5/00

CPC分类号： A61B5/1464 ,  A61B5/0097 ,  A61B5/02411 ,  A61B5/08 ,  A61B5/14542 ,  A61B5/7264 ,  A61B2562/0233 ,  A61B2562/043 ,  G01S15/8968

摘要： A method and system are presented for use in noninvasive monitoring at least one parameter of a region of interest in a human body. The system comprises a measurement unit and a control unit. The measurement unit comprises an optical unit having an illumination assembly configured to define at least one output port for illuminating light, and a light detection assembly configured to define at least one light input port for collecting light and to generate measured data indicative of the collected light; and an acoustic unit configured to generate acoustic waves of a predetermined ultrasound frequency range. The measurement unit is configured and operable to provide an operating condition such that the acoustic waves of the predetermined frequency range overlap with an illuminating region within the region of interest and substantially do not overlap with a region outside the region of interest, and that the detection assembly collects light scattered from the region of interest and light scattered from the region outside the region of interest. The measured data is thus indicative of scattered light having both ultrasound tagged and untagged light portions, thereby enabling to distinguish between light responses of the region of interest and the region outside the region of interest. The control unit is connectable to the optical unit and to the acoustic unit to operate these units, and is responsive to the measured data and preprogrammed to process and analyze the measured data to extract therefrom data indicative of a light response of the region of interest and determine the at least one desired parameter.

摘要翻译： 提出了一种方法和系统，用于非侵入性监测人体感兴趣区域的至少一个参数。 该系统包括测量单元和控制单元。 测量单元包括光学单元，其具有被配置为限定用于照明光的至少一个输出端口的照明组件;以及光检测组件，其被配置为限定用于收集光的至少一个光输入端口并且产生指示所收集的光的测量数据 ; 以及声学单元，被配置为产生预定的超声频率范围的声波。 测量单元被配置和操作以提供操作条件，使得预定频率范围的声波与感兴趣区域内的照明区域重叠，并且基本上不与感兴趣区域外的区域重叠，并且检测 装配收集从感兴趣区域以外的区域分散的光和从感兴趣区域以外的区域分散的光。 因此，所测量的数据表示具有超声标记和未标记的光部分的散射光，从而能够区分感兴趣区域的光响应和感兴趣区域之外的区域。 控制单元可连接到光学单元和声学单元以操作这些单元，并且响应于测量数据并被预编程以处理和分析测量数据以从其中提取指示感兴趣区域的光响应的数据，以及 确定至少一个期望的参数。

公开(公告)号：US08108022B2

公开(公告)日：2012-01-31

申请号：US11327381

申请日：2006-01-09

申请人： Michal Balberg ,  Revital Pery-Schechter ,  Michal Olshansky

发明人： Michal Balberg ,  Revital Pery-Schechter ,  Michal Olshansky

IPC分类号： A61B5/1455 ,  A61B6/00

CPC分类号： A61B5/1464 ,  A61B5/0097 ,  A61B5/02411 ,  A61B5/08 ,  A61B5/14542 ,  A61B5/7264 ,  A61B2562/0233 ,  A61B2562/043 ,  G01S15/8968

摘要： Apparatus and methods including a probe device for monitoring a parameter of a region of interest in a human body. A support structure of the device carries an arrangement of light output ports of a light source assembly, light input ports of a light detection assembly, and an acoustic output port of an acoustic unit. The arrangement is such as to enable selection of a light output port, a light input port, and an acoustic output port for an operating condition at which, acoustic waves from the acoustic output port and illuminating light from the light output port overlap in a region within the region of interest in the body thereby inducing tagging of light by the acoustic waves, and the light input port collects light scattered from the overlapping region and light scattered from outside the region of interest. Other embodiments are also described.

摘要翻译： 包括用于监测人体感兴趣区域的参数的探针装置的装置和方法。 该装置的支撑结构携带光源组件的光输出端口，光检测组件的光输入端口和声学单元的声输出端口的布置。 该布置使得能够选择光输出端口，光输入端口和声输出端口，用于来自声输出端口的声波和来自光输出端口的照明光在区域中重叠的操作条件 在体内感兴趣的区域内，由于声波引起光的标记，光输入端口收集从重叠区域散射的光和从感兴趣区域外部散射的光。 还描述了其它实施例。

公开(公告)号：US20080312533A1

公开(公告)日：2008-12-18

申请号：US10593318

申请日：2005-03-16

申请人： Michal Balberg ,  Revital Pery-Shechter ,  Michal Olshansky

发明人： Michal Balberg ,  Revital Pery-Shechter ,  Michal Olshansky

IPC分类号： A61B8/00 ,  A61B6/00

CPC分类号： A61B5/1455 ,  A61B5/14546 ,  A61B5/14553 ,  A61B5/7475 ,  A61B8/06 ,  A61B8/0808 ,  A61B8/0816 ,  A61B8/4227 ,  A61B8/4494 ,  A61B2562/0233 ,  A61B2562/043 ,  G01S15/8968

摘要： A measurement system and method are presented for use for non-invasive measurements in a human body. Acoustic radiation is applied to a certain illuminated region in the body, with at least two different conditions of the applied radiation achievable by varying at least one characteristic of the acoustic radiation. Light scattered from the body part is detected, and measured data indicative of detected photons tagged and untagged by the acoustic radiation is generated. The measured data is analyzed to extract therefrom a data portion corresponding to the tagged photons and being therefore associated with a light response of said certain region, thereby enabling determination of tissue properties of said certain region based on a relation between the measured data portions corresponding to the at least two different operating conditions.

摘要翻译： 提出了一种用于人体无创测量的测量系统和方法。 声辐射被施加到身体中的某个照明区域，通过改变声辐射的至少一个特征可以实现所施加辐射的至少两个不同条件。 检测到从身体部分散射的光，并且产生指示被声辐射标记和未标记的检测到的光子的测量数据。 分析测量数据以从其中提取对应于标记的光子的数据部分，并且因此与所述特定区域的光响应相关联，从而可以基于对应于所述特定区域的测量数据部分之间的关​​系来确定所述特定区域的组织属性 至少两个不同的操作条件。

公开(公告)号：US20060264717A1

公开(公告)日：2006-11-23

申请号：US10542600

申请日：2004-01-13

申请人： Benny Pesach ,  Gabriel Bitton ,  Michal Balberg

发明人： Benny Pesach ,  Gabriel Bitton ,  Michal Balberg

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/0095 ,  A61B5/14532 ,  G01N21/1702 ,  G01N29/2418 ,  G01N29/30 ,  G01N29/348 ,  G01N29/4427

摘要： A method of assaying an analyte in a body part comprising: illuminating the body part with at least one pulse of light at each of first and second wavelengths that stimulates photoacoustic waves in a first, target, region and a second, reference, region of the body part, wherein the reference region interfaces with the target region and has at least one known optoacoustic property and wherein light at the first wavelength is absorbed by the analyte; sensing pressure in the photoacoustic waves from the target and reference regions stimulated by the light at the first and second wavelengths; and using the sensed pressures and the at least one known optoacoustic property to assay the analyte in the target region.

摘要翻译： 一种测定身体部位中的分析物的方法，包括：用在第一和第二波长中的每一个处的至少一个脉冲光照射身体部分，以刺激第一，目标，区域和第二参考区域中的光声波 其中所述参考区域与所述目标区域接合并且具有至少一个已知的光声特性，并且其中所述第一波长处的光被所述分析物吸收; 感测来自由第一和第二波长的光刺激的目标和参考区域的光声波中的压力; 以及使用感测到的压力和至少一种已知的光声特性来测定目标区域中的分析物。