公开(公告)号：US20060034771A1

公开(公告)日：2006-02-16

申请号：US11231865

申请日：2005-09-22

申请人： Michel Schneider ,  Feng Yan ,  Pascal Grenier ,  Nadine Garcel ,  Jerome Puginier ,  Maria Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

发明人： Michel Schneider ,  Feng Yan ,  Pascal Grenier ,  Nadine Garcel ,  Jerome Puginier ,  Maria Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

IPC分类号： A61K49/22

CPC分类号： A61K49/223

摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.

公开(公告)号：US20050207980A1

公开(公告)日：2005-09-22

申请号：US11085169

申请日：2005-03-22

申请人： Michel Schneider ,  Feng Yan ,  Pascal Grenier ,  Nadine Garcel ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

发明人： Michel Schneider ,  Feng Yan ,  Pascal Grenier ,  Nadine Garcel ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

IPC分类号： A61B8/00 ,  A61B5/055 ,  A61K9/10 ,  A61K9/127 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K47/34 ,  A61K47/36 ,  A61K49/00 ,  A61K49/22

CPC分类号： A61K49/223 ,  A61K49/227 ,  Y10S514/975

摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.

摘要翻译： 在超声波回波成像中用作成像造影剂的水相中的气体或空气填充的微泡悬浮液。 它们含有层状表面活性剂和任选的亲水稳定剂。 层状表面活性剂可以是脂质体的形式。 通过在与水相混合之前或之后将层状表面活性剂暴露于空气或气体中获得悬浮液。

公开(公告)号：US20060257321A1

公开(公告)日：2006-11-16

申请号：US11444362

申请日：2006-06-01

申请人： Michel Schneider ,  Feng Yan ,  Nadine Garcel ,  Pascal Grenier ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

发明人： Michel Schneider ,  Feng Yan ,  Nadine Garcel ,  Pascal Grenier ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

IPC分类号： A61K49/00

CPC分类号： A61K49/223

摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.

公开(公告)号：US20050058605A1

公开(公告)日：2005-03-17

申请号：US10962460

申请日：2004-10-13

申请人： Michel Schneider ,  Feng Yan ,  Pascal Grenier ,  Nadine Garcel ,  Jerome Puginier ,  Marie-Bernadette Barrau

发明人： Michel Schneider ,  Feng Yan ,  Pascal Grenier ,  Nadine Garcel ,  Jerome Puginier ,  Marie-Bernadette Barrau

IPC分类号： A61K9/127 ,  A01N29/02 ,  A01N29/04 ,  A01N59/10 ,  A23J1/00 ,  A61B8/00 ,  A61K31/03 ,  A61K33/14 ,  A61K49/00 ,  A61K49/04 ,  A61K49/22 ,  C07K1/00

CPC分类号： A61K49/223

摘要： One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.