公开(公告)号：US20050272054A1

公开(公告)日：2005-12-08

申请号：US10995561

申请日：2004-11-24

申请人： Michele Cargill ,  Olga Iakoubova ,  James Devlin ,  Zenta Tsuchihashi ,  Peter Shaw ,  Lynn Ploughman ,  Kim Zerba ,  Koustubh Ranade ,  Todd Kirchgessner

发明人： Michele Cargill ,  Olga Iakoubova ,  James Devlin ,  Zenta Tsuchihashi ,  Peter Shaw ,  Lynn Ploughman ,  Kim Zerba ,  Koustubh Ranade ,  Todd Kirchgessner

IPC分类号： A61K31/225 ,  G01N33/50 ,  G01N33/68 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  A61K31/22 ,  A61K31/225 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  G01N33/6893 ,  G01N2800/32 ,  G01N2800/324

摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

摘要翻译： 本发明基于与心血管疾病特别是急性冠状动脉事件如心肌梗塞和中风相关的遗传多态性的发现，以及与个体对用他汀类药物治疗心血管疾病的反应性相关的遗传多态性。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。