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1.发明申请Human single nucleotide polymorphisms associated with dose-dependent weight gain and methods of use thereof 审中-公开与剂量依赖性重量增加相关的人单核苷酸多态性及其使用方法公开(公告)号：US20070202512A1
公开(公告)日：2007-08-30
申请号：US11505577
申请日：2006-08-17
申请人： Koustubh Ranade
发明人： Koustubh Ranade
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/715
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides novel polynucleotides and polypeptides associated with the incidence of PPAR-agonist associated weight gain and lower HbA1C levels. The invention also provides polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides which comprise at least one polymorphic locus per fragment. Allele-specific primers and probes which hybridize to these regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, medicine, and genetic analysis. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polynucleotides and/or polypeptides. The invention further relates to diagnostic methods for using these novel polynucleotides in the diagnosis, treatment, and/or prevention of various PPAR-related diseases and/or disorders, including weight gain.
摘要翻译： 本发明提供与PPAR-激动剂相关重量增加和较低HbA1C水平的发生相关的新型多核苷酸和多肽。 本发明还提供对应于这些多核苷酸的基因组和/或编码区的多核苷酸片段，其包含每个片段至少一个多态性位点。 还提供了与这些区域杂交的等位基因特异性引物和探针，和/或包含至少一个多态性位点。 本发明的多核苷酸，引物和探针可用于表型相关性，药物和遗传分析。 还提供了载体，宿主细胞，抗体以及用于产生所述多核苷酸和/或多肽的重组和合成方法。 本发明还涉及在诊断，治疗和/或预防各种PPAR相关疾病和/或病症（包括体重增加）中使用这些新型多核苷酸的诊断方法。
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公开(公告)号：US20140045924A1
公开(公告)日：2014-02-13
申请号：US13994291
申请日：2011-12-14
IPC分类号： C12N15/113
CPC分类号： C12N15/1135 , C12N15/113 , C12N2310/113 , C12N2310/141 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： Provided herein, in some embodiments, are methods for treating melanoma, improving therapeutic effectiveness of drugs and reducing drug toxicity.
摘要翻译： 在本文中，在一些实施方案中，是治疗黑素瘤的方法，提高药物的治疗有效性并降低药物毒性。
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3.发明申请公开(公告)号：US20090202994A1
公开(公告)日：2009-08-13
申请号：US12002453
申请日：2007-12-17
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides polynucleotide fragments corresponding to the genomic and/or coding regions of these genes which comprise at least one polymorphic site per fragment. Allele-specific primers and probes that hybridize to these regions, and/or that comprise at least one polymorphic site are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, paternity testing, medicine, and genetic analysis. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders, particularly cardiovascular diseases related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了对应于这些基因的基因组和/或编码区的多核苷酸片段，其包含每个片段至少一个多态性位点。 还提供了与这些区域杂交的等位基因特异性引物和探针，和/或包含至少一个多态性位点。 本发明的多核苷酸，引物和探针可用于表型相关性，亲子鉴定，药物和遗传分析。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型多肽应用于诊断，治疗和/或预防各种疾病和/或病症，特别是与这些多肽相关的心血管疾病的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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4.发明授权Method of identifying a PPARgamma-agonist compound having a decreased likelihood of inducing dose-dependent peripheral edema 有权鉴定具有诱导剂量依赖性外周水肿的可能性降低的PPARγ-激动剂化合物的方法公开(公告)号：US07482124B2
公开(公告)日：2009-01-27
申请号：US11483290
申请日：2006-07-07
CPC分类号： G01N33/5023 , C07K14/57536 , C07K14/70571 , C12N9/6486 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , C12Y304/23015 , G01N2333/70567 , G01N2500/10
摘要： The invention provides novel polynucleotides and polypeptides associated with the incidence of PPAR-agonist induced edema. The invention also provides polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides which comprise at least one polymorphic locus per fragment. Allele-specific primers and probes which hybridize to these regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, medicine, and genetic analysis. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel polynucleotides and polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders, particularly PPAR-agonist induced edema or related indications. The invention further relates to screening methods for identifying agonists of PPAR proteins with decreased risk of inducing peripheral edema in patients.
摘要翻译： 本发明提供与PPAR-激动剂诱导的水肿发生相关的新型多核苷酸和多肽。 本发明还提供对应于这些多核苷酸的基因组和/或编码区的多核苷酸片段，其包含每个片段至少一个多态性位点。 还提供了与这些区域杂交的等位基因特异性引物和探针，和/或包含至少一个多态性位点。 本发明的多核苷酸，引物和探针可用于表型相关性，药物和遗传分析。 还提供了载体，宿主细胞，抗体以及用于产生所述多核苷酸和/或多肽的重组和合成方法。 本发明还涉及将这些新的多核苷酸和多肽应用于各种疾病和/或病症，特别是PPAR激动剂诱导的水肿或相关适应症的诊断，治疗和/或预防的诊断和治疗方法。 本发明还涉及用于鉴定患者外周水肿风险降低的PPAR蛋白激动剂的筛选方法。
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5.发明授权Methods for diagnosing schizophrenia by detecting a polymorphism in the KalphaM1 gene 失效通过检测KalphaM1基因多态性诊断精神分裂症的方法公开(公告)号：US07329490B2
公开(公告)日：2008-02-12
申请号：US10941340
申请日：2004-09-15
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides polynucleotide fragments corresponding to the genomic and/or coding regions of these genes which comprise at least one polymorphic site per fragment. Allele-specific primers and probes that hybridize to these regions, and/or that comprise at least one polymorphic site are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, paternity testing, medicine, and genetic analysis. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders, particularly cardiovascular diseases related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了对应于这些基因的基因组和/或编码区的多核苷酸片段，其包含每个片段至少一个多态性位点。 还提供了与这些区域杂交的等位基因特异性引物和探针，和/或包含至少一个多态性位点。 本发明的多核苷酸，引物和探针可用于表型相关性，亲子鉴定，药物和遗传分析。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型多肽应用于诊断，治疗和/或预防各种疾病和/或病症，特别是与这些多肽相关的心血管疾病的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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6.发明申请Single nucleotide polymorphisms associated with dose-dependent edema and methods of use thereof 有权与剂量依赖性水肿相关的单核苷酸多态性及其使用方法公开(公告)号：US20070009945A1
公开(公告)日：2007-01-11
申请号：US11483290
申请日：2006-07-07
申请人： Koustubh Ranade , Terrye Delmonte , William Geese
发明人： Koustubh Ranade , Terrye Delmonte , William Geese
IPC分类号： C12Q1/68 , G01N33/567 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： G01N33/5023 , C07K14/57536 , C07K14/70571 , C12N9/6486 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , C12Y304/23015 , G01N2333/70567 , G01N2500/10
摘要： The invention provides novel polynucleotides and polypeptides associated with the incidence of PPAR-agonist induced edema. The invention also provides polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides which comprise at least one polymorphic locus per fragment. Allele-specific primers and probes which hybridize to these regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, medicine, and genetic analysis. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel polynucleotides and polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders, particularly PPAR-agonist induced edema or related indications. The invention further relates to screening methods for identifying agonists of PPAR proteins with decreased risk of inducing periphereal edema in patients.
摘要翻译： 本发明提供与PPAR-激动剂诱导的水肿发生相关的新型多核苷酸和多肽。 本发明还提供对应于这些多核苷酸的基因组和/或编码区的多核苷酸片段，其包含每个片段至少一个多态性位点。 还提供了与这些区域杂交的等位基因特异性引物和探针，和/或包含至少一个多态性位点。 本发明的多核苷酸，引物和探针可用于表型相关性，药物和遗传分析。 还提供了载体，宿主细胞，抗体以及用于产生所述多核苷酸和/或多肽的重组和合成方法。 本发明还涉及将这些新的多核苷酸和多肽应用于各种疾病和/或病症，特别是PPAR激动剂诱导的水肿或相关适应症的诊断，治疗和/或预防的诊断和治疗方法。 本发明进一步涉及用于鉴定患者外周水肿风险降低的PPAR蛋白激动剂的筛选方法。
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7.发明申请Human MLR single nucleotide polymorphisms associated with dose-dependent congestive heart failure and methods of use thereof 审中-公开与剂量依赖性充血性心力衰竭相关的人MLR单核苷酸多态性及其使用方法公开(公告)号：US20070190539A1
公开(公告)日：2007-08-16
申请号：US11498489
申请日：2006-08-03
申请人： Koustubh Ranade
发明人： Koustubh Ranade
IPC分类号： C12Q1/68 , C07H21/04 , C07K14/705
CPC分类号： C07K14/705 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The invention provides novel polynucleotides and polypeptides associated with the incidence of PPAR-agonist induced congestive heart failure. The invention also provides polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides which comprise at least one polymorphic locus per fragment. Allele-specific primers and probes which hybridize to these regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, medicine, and genetic analysis. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel polynucleotides and polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders, particularly PPAR-agonist induced congestive heart failure or related indications.
摘要翻译： 本发明提供了与PPAR-激动剂诱导的充血性心力衰竭发生相关的新型多核苷酸和多肽。 本发明还提供对应于这些多核苷酸的基因组和/或编码区的多核苷酸片段，其包含每个片段至少一个多态性位点。 还提供了与这些区域杂交的等位基因特异性引物和探针，和/或包含至少一个多态性位点。 本发明的多核苷酸，引物和探针可用于表型相关性，药物和遗传分析。 还提供了载体，宿主细胞，抗体以及用于产生所述多核苷酸和/或多肽的重组和合成方法。 本发明还涉及将这些新的多核苷酸和多肽应用于各种疾病和/或病症，特别是PPAR-激动剂诱导的充血性心力衰竭或相关适应症的诊断，治疗和/或预防的诊断和治疗方法。
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公开(公告)号：US20130108646A1
公开(公告)日：2013-05-02
申请号：US13695714
申请日：2011-05-04
IPC分类号： A61K39/395 , A61K45/00 , A61K39/00 , A61K31/56 , A61K35/34 , A61K31/7088
CPC分类号： A61K39/3955 , A61K31/56 , A61K31/7088 , A61K35/34 , A61K39/00 , A61K45/00 , C12Q1/6883 , C12Q2600/106 , C12Q2600/178 , G01N33/6893 , G01N2333/535 , G01N2800/10 , G01N2800/52
摘要： Provided herein are optimized methods for treating a degenerative muscle disease, which comprise determining the presence, absence or amount of a biomarker associated with the disease after a drug has been administered, and determining whether a subsequent dose of the drug should be maintained, increased or decreased based on the biomarker assessment. Increased levels of certain biomarkers are linked to muscle degenerative diseases (e.g., GM-CSF(CSF2), TNF-alpha or other pro-inflammatory cytokine acting through NF kappa B), and decreased levels of certain biomarkers are linked to the muscle degenerative diseases 9 e.g., particular microRNA (e.g., miRNA-1, miRNA-133, miRNA-206)). Such methods optimize therapeutic efficacy and minimize toxicity associated with a drug. Also provided herein are therapeutics for treating muscle disorders.
摘要翻译： 本文提供了用于治疗退行性肌肉疾病的优化方法，其包括确定在施用药物后与疾病相关的生物标志物的存在，不存在或量的量，以及确定是否应维持，增加药物的后续剂量 基于生物标志物评估减少。 某些生物标志物的增加水平与肌肉退行性疾病（例如，GM-CSF（CSF2），TNF-α或通过NFκBB作用的其它促炎细胞因子）相关，并且某些生物标志物的降低水平与肌肉退行性疾病相关 例如，特定的微小RNA（例如，miRNA-1，miRNA-133，miRNA-206））。 这样的方法优化治疗功效并最小化与药物相关的毒性。 本文还提供了治疗肌肉疾病的治疗剂。
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9.发明授权Method for identifying HIV-1 protease inhibitors with reduced metabolic affects through detection of human resistin polymorphisms 有权用于通过检测人抵抗素多态性鉴定具有降低的代谢影响的HIV-1蛋白酶抑制剂的方法公开(公告)号：US07642049B2
公开(公告)日：2010-01-05
申请号：US11823707
申请日：2007-06-27
申请人： Koustubh Ranade
发明人： Koustubh Ranade
CPC分类号： C07K14/575 , C12Q1/6827
摘要： The invention provides a novel in vitro method for identifying HIV-1 protease inhibitors with reduced potential for inducing metabolic abnormalities. The invention further provides diagnostic methods for identifying patients who may be at risk of developing metabolic abnormalities subsequent to the administration of an HIV-1 protease inhibitor. The invention also provides novel polynucleotides associated with the incidence of HIV-1 protease inhibitor induced metabolic abnormalities. The invention also provides polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides which comprise at least one polymorphic locus per fragment. Allele-specific primers and probes which hybridize to these regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, medicine, and genetic analysis. The invention further relates to diagnostic methods for using these novel polynucleotides in the diagnosis, treatment, and/or prevention of HIV-1 protease inhibitor induced metabolic abnormalities.
摘要翻译： 本发明提供了用于鉴定具有诱导代谢异常的潜力降低的HIV-1蛋白酶抑制剂的新型体外方法。 本发明还提供用于鉴定在施用HIV-1蛋白酶抑制剂之后可能处于发生代谢异常风险的患者的诊断方法。 本发明还提供了与HIV-1蛋白酶抑制剂诱导的代谢异常的发生相关的新型多核苷酸。 本发明还提供对应于这些多核苷酸的基因组和/或编码区的多核苷酸片段，其包含每个片段至少一个多态性位点。 还提供了与这些区域杂交的等位基因特异性引物和探针，和/或包含至少一个多态性位点。 本发明的多核苷酸，引物和探针可用于表型相关性，药物和遗传分析。 本发明还涉及在诊断，治疗和/或预防HIV-1蛋白酶抑制剂诱导的代谢异常中使用这些新型多核苷酸的诊断方法。
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公开(公告)号：US20090117535A1
公开(公告)日：2009-05-07
申请号：US12317322
申请日：2008-12-22
申请人： William J. Geese , Koustubh Ranade
发明人： William J. Geese , Koustubh Ranade
IPC分类号： C12Q1/00
CPC分类号： C07K14/575 , C12Q1/6827
摘要： The invention provides a novel in vitro method for identifying HIV-1 protease inhibitors with reduced potential for inducing metabolic abnormalities. The invention further provides diagnostic methods for identifying patients who may be at risk of developing metabolic abnormalities subsequent to the administration of an HIV-1 protease inhibitor. The invention also provides novel polynucleotides associated with the incidence of HIV-1 protease inhibitor induced metabolic abnormalities. The invention also provides polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides which comprise at least one polymorphic locus per fragment. Allele-specific primers and probes which hybridize to these regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, medicine, and genetic analysis. The invention further relates to diagnostic methods for using these novel polynucleotides in the diagnosis, treatment, and/or prevention of HIV-1 protease inhibitor induced metabolic abnormalities.
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