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    [3,4-a:3,4-c]carbazole compounds
    1.
    发明授权
    [3,4-a:3,4-c]carbazole compounds 失效
    [3,4-a：3,4-c]咔唑化合物

    公开(公告)号：US07151108B2

    公开(公告)日：2006-12-19

    申请号：US10672418

    申请日：2003-09-26

    申请人： Michelle Prudhomme ,  Bernadette Hugon ,  Fabrice Anizon ,  John Hickman ,  Alain Pierre ,  Roy Golsteyn ,  Pierre Renard ,  Bruno Pfeiffer

    发明人： Michelle Prudhomme ,  Bernadette Hugon ,  Fabrice Anizon ,  John Hickman ,  Alain Pierre ,  Roy Golsteyn ,  Pierre Renard ,  Bruno Pfeiffer

    IPC分类号： A61K31/437 ,  A61K31/403 ,  C07D471/22 ,  C07D487/14 ,  C07D491/14

    CPC分类号： C07D487/14 ,  A61K9/0019 ,  C07D491/14 ,  C07H19/23

    摘要： A compound selected from those of formula (I): wherein: W1 represents, together with carbon to which it is bonded, phenyl, pyridyl, Z represents a group of formula U—V as defined in the description, Q1 represents oxygen, NR2 as defined in the description, Q2 represents oxygen, NR′2 as defined in the description, X1, X2, X′1 and X′2 each represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y1, Y2, Y′1 and Y′2 each represents hydrogen, or X1 and Y1, X2 and Y2, X′1 and Y′1, X′2 and Y′2 with carbon carrying them, together form carbonyl or thiocarbonyl, R1 is as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

    摘要翻译： 选自式（I）的化合物：其中：W 1代表与其键合的碳一起，苯基，吡啶基，Z代表如说明书中所定义的式UV基团， Q 1表示氧，NR 2，如说明书中所定义，Q 2表示氧，NR'2， 定义在说明书中，X 1，X 2，X'1和X'2各自表示氢， 羟基，烷氧基，巯基或烷硫基，Y 1，Y 2，Y'1和Y'2各自 表示氢，或X 1和Y 1，X 2和Y 2，X'1 和/或Y'1，X'2，Y'2，和携带它们的碳一起形成羰基或硫代羰基， 如本说明书中所定义，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有它们的药物，其可用于tr 吃癌。

    12,13-(pyranosyl)-indolo[2,3-a]pyrrolo[3,4-c]carbazole and 12,13-(pyranosyl)-furo[3,4-c]indolo[2,3-a]carbazoles
    3.
    发明授权
    12,13-(pyranosyl)-indolo[2,3-a]pyrrolo[3,4-c]carbazole and 12,13-(pyranosyl)-furo[3,4-c]indolo[2,3-a]carbazoles 失效
    12,13-（吡喃糖基） - 吲哚并[2,3-a]吡咯并[3,4-c]咔唑和12,13-（吡喃糖基） - 呋喃并[3,4-c]吲哚并[2,3-a] 咔唑

    公开(公告)号：US06569858B2

    公开(公告)日：2003-05-27

    申请号：US10010379

    申请日：2001-11-05

    申请人： Michelle Prudhomme ,  Pascale Moreau ,  Fabrice Anizon ,  Christelle Marminon ,  Ghanem Atassi ,  Alain Pierre ,  Bruno Pfeiffer ,  Pierre Renard

    发明人： Michelle Prudhomme ,  Pascale Moreau ,  Fabrice Anizon ,  Christelle Marminon ,  Ghanem Atassi ,  Alain Pierre ,  Bruno Pfeiffer ,  Pierre Renard

    IPC分类号： C07D49044

    CPC分类号： C07H19/23

    摘要： A compound selected from those of formula (I): wherein: R1 and R2, which may be identical or different, represent a group of formula U-V wherein U represents single bond, or alkylene which is optionally substituted and/or unsaturated, and V is as defined in the description, G represents oxygen, or NR3 wherein R3 is as defined in the description, X represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y represents hydrogen, or X+Y represents carbonyl, X1 represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y1 represents hydrogen, or X1+Y1 represents carbonyl, R4, R5, and R6 are as defined in the description, its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same are useful in the treatment of cancer.

    摘要翻译： 选自式（I）的化合物：其中：R 1和R 2可以相同或不同，表示其中U表示单键的式UV基团，或任选被取代和/或不饱和的亚烷基，V是 G表示氧或NR 3，其中R3如说明书中所定义，X表示氢，羟基，烷氧基，巯基或烷硫基，Y表示氢，或X + Y表示羰基，X1表示氢，羟基， 烷氧基，巯基或烷硫基，Y1表示氢，或X1 + Y1表示羰基，R4，R5和R6如说明书中所定义，其异构体及其药学上可接受的酸或碱加成盐，以及含有它们的药物 可用于治疗癌症。