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公开(公告)号：US20180292319A1
公开(公告)日：2018-10-11
申请号：US15804869
申请日：2017-11-06
申请人： Micronics, Inc.
CPC分类号： G01N21/6428 , B01L3/502715 , B01L7/52 , B01L2200/0684 , B01L2300/0816 , B01L2300/168 , B01L2300/1827 , B01L2300/1844 , B01L2400/0487 , G01N21/645 , G01N2201/062 , G01N2201/12 , Y02A90/26
摘要： Disclosed is a compact, microprocessor-controlled instrument for fluorometric assays in liquid samples, the instrument having a floating stage with docking bay for receiving a microfluidic cartridge and a scanning detector head with on-board embedded microprocessor operated under control of a ODAP daemon resident in the detector head for controlling source LEDs, emission signal amplification and filtering in an isolated, low noise, high-gain environment within the detector head. Multiple optical channels may be incorporated in the scanning head. In a preferred configuration, the assay is validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. Applications include molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general, many of which require temperature control during detection. Sensitivity and resistance to bubble interference during scanning are shown to be improved by use of a heating block with reflective mirror face in intimate contact with a thermo-optical window enclosing the liquid sample.
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公开(公告)号：US20140349381A1
公开(公告)日：2014-11-27
申请号：US14219905
申请日：2014-03-19
申请人： Micronics, Inc.
IPC分类号： G01N21/64
CPC分类号： G01N21/6456 , B01L7/52 , C12M23/16 , G01N21/645 , G01N21/6452 , G01N21/6454 , G01N2201/0245
摘要： An instrument for fluorometric assays in liquid samples is disclosed. The instrument may include multiple optical channels for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. The disclosed instrument finds utility in any number of applications, including microfluidic molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general.
摘要翻译： 公开了用于液体样品中的荧光测定的仪器。 仪器可以包括用于监测与靶分析物相关联的第一荧光团的多个光学通道和与对照相关联的第二荧光团。 所公开的仪器可用于任何数量的应用，包括基于目标核酸的PCR扩增和荧光测定的微流体分子生物学测定。
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公开(公告)号：US10436713B2
公开(公告)日：2019-10-08
申请号：US15804869
申请日：2017-11-06
申请人： Micronics, Inc.
摘要： A compact, microprocessor-controlled instrument for fluorometric assays in liquid samples has a floating stage with docking bay for receiving a microfluidic cartridge and a scanning detector head with on-board embedded microprocessor controlled by an optical data acquisition and processing daemon within the detector head for controlling source LEDs, emission signal amplification and filtering in an isolated, low noise, high-gain environment within the detector head. Multiple optical channels may be incorporated in the scanning head. The assay ma be validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. Molecular biological assays use PCR amplification of target nucleic acids and fluorometric assays, which may require temperature control during detection. Sensitivity and resistance to bubble interference during scanning are improved using a heating block with reflective mirror face in contact with a thermo-optical window enclosing the liquid sample.
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4.发明申请PORTABLE FLUORESCENCE DETECTION SYSTEM AND MICROASSAY CARTRIDGE 审中-公开便携式荧光检测系统和MICROASSAY CARTRIDGE公开(公告)号：US20150346097A1
公开(公告)日：2015-12-03
申请号：US14653726
申请日：2013-12-20
申请人： MICRONICS, INC.
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , B01L3/502715 , B01L7/52 , B01L2200/0684 , B01L2300/0816 , B01L2300/168 , B01L2300/1827 , B01L2300/1844 , B01L2400/0487 , G01N21/645 , G01N2201/062 , G01N2201/12 , Y02A90/26
摘要： Disclosed is a compact, microprocessor-controlled instrument for fluorometric assays in liquid samples, the instrument having a floating stage with docking bay for receiving a microfluidic cartridge and a scanning detector head with on-board embedded microprocessor operated under control of a ODAP daemon resident in the detector head for controlling source LEDs, emission signal amplification and filtering in an isolated, low noise, high-gain environment within the detector head. Multiple optical channels may be incorporated in the scanning head. In a preferred configuration, the assay is validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. Applications include molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general, many of which require temperature control during detection.
摘要翻译： 公开了一种紧凑的微处理器控制的液体样品中的荧光测定仪器，该仪器具有一个带有用于接收微流控盒的对接托架的浮动台和一个带有板上嵌入式微处理器的扫描检测器， 用于控制源LED的检测器头，在检测器头内的隔离，低噪声，高增益环境中的发射信号放大和滤波。 多个光通道可并入扫描头。 在优选的配置中，使用双通道光学器件验证测定，用于监测与靶分析物相关联的第一荧光团和与对照相关联的第二荧光团。 应用包括基于目标核酸的PCR扩增和荧光测定的分子生物测定法，其中许多在检测期间需要温度控制。
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