公开(公告)号：US20060252812A1

公开(公告)日：2006-11-09

申请号：US11402310

申请日：2006-04-11

申请人： Mikhail Chafeev ,  Nagasree Chakka ,  Sultan Chowdhury ,  Robert Fraser ,  Jianmin Fu ,  Duanjie Hou ,  Tom Hsieh ,  Rajender Kamboj ,  Shifeng Liu ,  Vandna Raina ,  Mehran Bagherzadeh ,  Jianyu Sun ,  Shaoyi Sun ,  Serguei Sviridov

发明人： Mikhail Chafeev ,  Nagasree Chakka ,  Sultan Chowdhury ,  Robert Fraser ,  Jianmin Fu ,  Duanjie Hou ,  Tom Hsieh ,  Rajender Kamboj ,  Shifeng Liu ,  Vandna Raina ,  Mehran Bagherzadeh ,  Jianyu Sun ,  Shaoyi Sun ,  Serguei Sviridov

IPC分类号： A61K31/407 ,  C07D491/10

CPC分类号： C07D491/10

摘要： This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

摘要翻译： 本发明涉及式（I）的螺 - 羟吲哚化合物：其中k，j，Q，R 1，R 2a，R 2b， >，R 2c，R 2d，R 3a，R 3b，R 3c， >和R“>如本文所定义，作为其立体异构体，对映异构体，互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药，其可用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。 还公开了包含化合物的药物组合物以及制备和使用化合物的方法。

公开(公告)号：US10140658B1

公开(公告)日：2018-11-27

申请号：US14300204

申请日：2014-06-09

申请人： Mehran Bagherzadeh

发明人： Mehran Bagherzadeh

IPC分类号： G06Q40/00 ,  G06Q40/04 ,  G06Q20/10 ,  G06Q40/02

摘要： A computerized method for managing a user account includes receiving a transfer of funds into a user account, and purchasing a commodity or valuable asset to back the funds. The method further includes tracking a value of the commodity or valuable asset, and increasing or decreasing a value of the funds based on the value of the commodity or valuable asset. The user account is accessible via a computer network for making purchases or an additional transfer of the funds to another user account. The commodity may be gold, silver, or platinum bullion. The valuable asset may be a stock or bond.