利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.026 秒)

    Methods and compositions for diagnosing and suppressing metastasis thereof
    4.
    发明授权
    Methods and compositions for diagnosing and suppressing metastasis thereof 有权
    用于诊断和抑制其转移的方法和组合物

    公开(公告)号：US07214480B2

    公开(公告)日：2007-05-08

    申请号：US10871407

    申请日：2004-06-18

    申请人： Min-Liang Kuo ,  Cheng-Chi Chang

    发明人： Min-Liang Kuo ,  Cheng-Chi Chang

    IPC分类号： C12Q1/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/574

    CPC分类号： G01N33/574 ,  A61K38/18 ,  A61K48/005 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/5023 ,  G01N33/5044

    摘要： Disclosed is a method for determining metastatic potential of tumors, a method and a composition for treating/suppressing metastasis of cancers, as well as a method for obtaining a metastasis suppressor. A particular aspect of the invention relates to a method and a composition of evaluating expression levels of connective tissue growth factor (CTGF, also known as CCN2) to determine the status of tumor invasion. Another aspect of the invention relates to a method and a composition comprising a tumor suppressor, which maintains or increases an expression level of CTGF to suppress the invasion ability of tumor cells effectively. In another aspect of the invention relates to methods for obtaining a metastasis suppressor by evaluating the expression levels of CTGF after contacting suppressor candidates with a tumor cell line system.

    摘要翻译： 公开了用于确定肿瘤转移潜力的方法，用于治疗/抑制癌转移的方法和组合物，以及获得转移抑制因子的方法。 本发明的一个特定方面涉及评估结缔组织生长因子（CTGF，也称为CCN2）的表达水平以确定肿瘤侵袭状态的方法和组合物。 本发明的另一方面涉及包含肿瘤抑制因子的方法和组合物，其维持或增加CTGF的表达水平以有效抑制肿瘤细胞的侵袭能力。 本发明的另一方面涉及通过在将抑制剂候选物与肿瘤细胞系系接触后评价CTGF的表达水平来获得转移抑制基因的方法。

    METHOD FOR INHIBITING PERITONEAL METASTASIS CAUSED BY GASTRIC CANCER CELLS
    5.
    发明申请
    METHOD FOR INHIBITING PERITONEAL METASTASIS CAUSED BY GASTRIC CANCER CELLS 审中-公开
    抑制由胃癌细胞引起的骨质疏松的方法

    公开(公告)号：US20140162950A1

    公开(公告)日：2014-06-12

    申请号：US13709534

    申请日：2012-12-10

    申请人： Cheng-Chi Chang ,  Chiung-Nien Chen ,  Hsin-Yu Li ,  Min-Liang Kuo

    发明人： Cheng-Chi Chang ,  Chiung-Nien Chen ,  Hsin-Yu Li ,  Min-Liang Kuo

    IPC分类号： A61K38/18

    CPC分类号： A61K38/18 ,  G01N33/5088 ,  G01N33/57446 ,  G01N2800/50 ,  G01N2800/52

    摘要： The present invention provides a method for inhibiting peritoneal metastasis caused by gastric cancer cells in a subject in need thereof comprising administering to the subject a pharmaceutically effective amount of a connective tissue growth factor (CTGF), wherein the CTGF binds to an integrin α3β1 of the gastric cancer cells. The present invention also provides a method for predicting peritoneal metastasis caused by gastric cancer cells in a subject comprising providing a peritoneal tissue from the subject; measuring a first expression amount of a connective tissue growth factor (CTGF) from the peritoneal tissue; and comparing the first expression amount to a reference expression amount of the CTGF from a non-peritoneal metastasis gastric cancer tissue.

    摘要翻译： 本发明提供一种抑制需要治疗的受试者胃癌细胞引起的腹膜转移的方法，包括向受试者施用药学有效量的结缔组织生长因子（CTGF），其中CTGF与整联蛋白α3和bgr1结合 的胃癌细胞。 本发明还提供一种预测受试者胃癌细胞引起的腹膜转移的方法，包括从受试者提供腹膜组织; 测量来自腹膜组织的结缔组织生长因子（CTGF）的第一表达量; 并将第一表达量与来自非腹膜转移性胃癌组织的CTGF的参照表达量进行比较。

    Methods and compositions for diagnosing and suppressing metastasis thereof
    6.
    发明授权
    Methods and compositions for diagnosing and suppressing metastasis thereof 有权
    用于诊断和抑制其转移的方法和组合物

    公开(公告)号：US07618772B2

    公开(公告)日：2009-11-17

    申请号：US11689286

    申请日：2007-03-21

    申请人： Min-Liang Kuo ,  Cheng-Chi Chang

    发明人： Min-Liang Kuo ,  Cheng-Chi Chang

    IPC分类号： C12Q1/00 ,  C12Q1/68 ,  G01N33/574 ,  G01N33/53

    CPC分类号： G01N33/57484 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2333/475

    摘要： Disclosed is a method for determining metastatic potential of tumors, a method and a composition for treating/suppressing metastasis of cancers, as well as a method for obtaining a metastasis suppressor. A particular aspect of the invention relates to a method and a composition of evaluating expression levels of connective tissue growth factor (CTGF, also known as CCN2) to determine the status of tumor invasion. Another aspect of the invention relates to a method and a composition comprising a tumor suppressor, which maintains or increases an expression level of CTGF to suppress the invasion ability of tumor cells effectively. In another aspect of the invention relates to methods for obtaining a metastasis suppressor by evaluating the expression levels of CTGF after contacting suppressor candidates with a tumor cell line system.

    摘要翻译： 公开了用于确定肿瘤转移潜力的方法，用于治疗/抑制癌转移的方法和组合物，以及获得转移抑制因子的方法。 本发明的一个特定方面涉及评估结缔组织生长因子（CTGF，也称为CCN2）的表达水平以确定肿瘤侵袭状态的方法和组合物。 本发明的另一方面涉及包含肿瘤抑制因子的方法和组合物，其维持或增加CTGF的表达水平以有效抑制肿瘤细胞的侵袭能力。 本发明的另一方面涉及通过在将抑制剂候选物与肿瘤细胞系系接触后评价CTGF的表达水平来获得转移抑制基因的方法。

    METHODS AND COMPOSITIONS FOR DIAGNOSING AND SUPPRESSING METASTASIS THEREOF
    7.
    发明申请
    METHODS AND COMPOSITIONS FOR DIAGNOSING AND SUPPRESSING METASTASIS THEREOF 有权

    公开(公告)号：US20070172876A1

    公开(公告)日：2007-07-26

    申请号：US11689286

    申请日：2007-03-21

    申请人： Min-Liang Kuo ,  Cheng-Chi Chang

    发明人： Min-Liang Kuo ,  Cheng-Chi Chang

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： G01N33/57484 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2333/475

    摘要： Disclosed is a method for determining metastatic potential of tumors, a method and a composition for treating/suppressing metastasis of cancers, as well as a method for obtaining a metastasis suppressor. A particular aspect of the invention relates to a method and a composition of evaluating expression levels of connective tissue growth factor (CTGF, also known as CCN2) to determine the status of tumor invasion. Another aspect of the invention relates to a method and a composition comprising a tumor suppressor, which maintains or increases an expression level of CTGF to suppress the invasion ability of tumor cells effectively. In another aspect of the invention relates to methods for obtaining a metastasis suppressor by evaluating the expression levels of CTGF after contacting suppressor candidates with a tumor cell line system.

    METHODS AND COMPOSITIONS FOR DIAGNOSING AND SUPPRESSING METASTASIS THEREOF
    8.
    发明申请
    METHODS AND COMPOSITIONS FOR DIAGNOSING AND SUPPRESSING METASTASIS THEREOF 审中-公开
    用于诊断和抑制METASTASIS的方法和组合物

    公开(公告)号：US20070167394A1

    公开(公告)日：2007-07-19

    申请号：US11689306

    申请日：2007-03-21

    申请人： Min-Liang Kuo ,  Cheng-Chi Chang

    发明人： Min-Liang Kuo ,  Cheng-Chi Chang

    IPC分类号： A61K48/00

    CPC分类号： G01N33/574 ,  A61K38/18 ,  A61K48/005 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/5023 ,  G01N33/5044

    摘要： Disclosed is a method for determining metastatic potential of tumors, a method and a composition for treating/suppressing metastasis of cancers, as well as a method for obtaining a metastasis suppressor. A particular aspect of the invention relates to a method and a composition of evaluating expression levels of connective tissue growth factor (CTGF, also known as CCN2) to determine the status of tumor invasion. Another aspect of the invention relates to a method and a composition comprising a tumor suppressor, which maintains or increases an expression level of CTGF to suppress the invasion ability of tumor cells effectively. In another aspect of the invention relates to methods for obtaining a metastasis suppressor by evaluating the expression levels of CTGF after contacting suppressor candidates with a tumor cell line system.

    摘要翻译： 公开了用于确定肿瘤转移潜力的方法，用于治疗/抑制癌转移的方法和组合物，以及获得转移抑制因子的方法。 本发明的一个特定方面涉及评估结缔组织生长因子（CTGF，也称为CCN2）的表达水平以确定肿瘤侵袭状态的方法和组合物。 本发明的另一方面涉及包含肿瘤抑制因子的方法和组合物，其维持或增加CTGF的表达水平以有效抑制肿瘤细胞的侵袭能力。 本发明的另一方面涉及通过在将抑制剂候选物与肿瘤细胞系系接触后评价CTGF的表达水平来获得转移抑制基因的方法。

    Methods and compositions for diagnosing and suppressing metastasis thereof
    9.
    发明申请
    Methods and compositions for diagnosing and suppressing metastasis thereof 有权
    用于诊断和抑制其转移的方法和组合物

    公开(公告)号：US20050147986A1

    公开(公告)日：2005-07-07

    申请号：US10871407

    申请日：2004-06-18

    申请人： Min-Liang Kuo ,  Cheng-Chi Chang

    发明人： Min-Liang Kuo ,  Cheng-Chi Chang

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： G01N33/574 ,  A61K38/18 ,  A61K48/005 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/5023 ,  G01N33/5044

    摘要： Disclosed is a method for determining metastatic potential of tumors, a method and a composition for treating/suppressing metastasis of cancers, as well as a method for obtaining a metastasis suppressor. A particular aspect of the invention relates to a method and a composition of evaluating expression levels of connective tissue growth factor (CTGF, also known as CCN2) to determine the status of tumor invasion. Another aspect of the invention relates to a method and a composition comprising a tumor suppressor, which maintains or increases an expression level of CTGF to suppress the invasion ability of tumor cells effectively. In another aspect of the invention relates to methods for obtaining a metastasis suppressor by evaluating the expression levels of CTGF after contacting suppressor candidates with a tumor cell line system.

    摘要翻译： 公开了用于确定肿瘤转移潜力的方法，用于治疗/抑制癌转移的方法和组合物，以及获得转移抑制因子的方法。 本发明的一个特定方面涉及评估结缔组织生长因子（CTGF，也称为CCN2）的表达水平以确定肿瘤侵袭状态的方法和组合物。 本发明的另一方面涉及包含肿瘤抑制因子的方法和组合物，其维持或增加CTGF的表达水平以有效抑制肿瘤细胞的侵袭能力。 本发明的另一方面涉及通过在将抑制剂候选物与肿瘤细胞系系接触后评价CTGF的表达水平来获得转移抑制基因的方法。