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公开(公告)号：US08962261B2
公开(公告)日：2015-02-24
申请号：US14001827
申请日：2012-04-06
申请人： Minnie M. Sarwal , Tara Sigdel , Sang H. Woo , Richard Lafayette
发明人： Minnie M. Sarwal , Tara Sigdel , Sang H. Woo , Richard Lafayette
IPC分类号： G01N33/53 , G01N33/68 , G01N33/564
CPC分类号： G01N33/6854 , G01N33/564 , G01N33/6893 , G01N2800/347
摘要： Aspects of the present invention include methods for diagnosing and monitoring IgAN in a subject. In practicing one aspect of the subject methods, a sample from a subject is analyzed for the presence of one or more specific autoantibodies to determine the IgAN phenotype of the subject. Also provided are compositions, systems, kits and computer program products that find use in practicing the subject methods. The methods and compositions find use in a variety of applications.
摘要翻译： 本发明的方面包括用于诊断和监测受试者中IgAN的方法。 在实施本发明方法的一个方面时，分析来自受试者的样品中存在一种或多种特异性自身抗体以确定受试者的IgAN表型。 还提供了用于实践主题方法的组合物，系统，试剂盒和计算机程序产品。 这些方法和组合物可用于各种应用。
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公开(公告)号：US20140141449A1
公开(公告)日：2014-05-22
申请号：US14001827
申请日：2012-04-06
申请人： Minnie M. Sarwal , Tara Sigdel , Sang H. Woo , Richard Lafayette
发明人： Minnie M. Sarwal , Tara Sigdel , Sang H. Woo , Richard Lafayette
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , G01N33/564 , G01N33/6893 , G01N2800/347
摘要： Aspects of the present invention include methods for diagnosing and monitoring IgAN in a subject. In practicing one aspect of the subject methods, a sample from a subject is analyzed for the presence of one or more specific autoantibodies to determine the IgAN phenotype of the subject. Also provided are compositions, systems, kits and computer program products that find use in practicing the subject methods. The methods and compositions find use in a variety of applications.
摘要翻译： 本发明的方面包括用于诊断和监测受试者中IgAN的方法。 在实施本发明方法的一个方面时，分析来自受试者的样品中存在一种或多种特异性自身抗体以确定受试者的IgAN表型。 还提供了用于实践主题方法的组合物，系统，试剂盒和计算机程序产品。 这些方法和组合物可用于各种应用。
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公开(公告)号：US20130143755A1
公开(公告)日：2013-06-06
申请号：US13635667
申请日：2011-03-25
申请人： Minnie M. Sarwal , Tara Sigdel , Amit Kaushal , Li Li , Wenzhong Xiao , Atul J. Butte , Purvesh Khatri
发明人： Minnie M. Sarwal , Tara Sigdel , Amit Kaushal , Li Li , Wenzhong Xiao , Atul J. Butte , Purvesh Khatri
CPC分类号： G01N33/6893 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , G01N2800/245
摘要： Aspects of the present invention include methods for determining a transplant category of a subject having a transplant. Common mechanisms of rejection injury are uncovered across different tissue transplants, and provide a means to understand rational drug design. Various sources of tissues are examined form the patient for understanding AR mechanism (graft biopsy), as well as monitoring by minimal invasive means (blood) or non-invasive means (urine for the kidney allograft). For biomarker discovery different categories of markers are examined such as genes, proteins, peptides and antibodies. These biomarkers can help determine the subject's transplant category (e.g., acute allograft rejection (AR), stable allograft (STA), BK viremia, BK nephritis, drug toxicity or chronic allograft injury (CAI), and the like). Also provided are compositions, systems, kits and computer program products that find use in practicing the subject methods. The methods and compositions find use in a variety of applications.
摘要翻译： 本发明的方面包括用于确定具有移植物的受试者的移植类别的方法。 排除损伤的常见机制在不同的组织移植中被发现，并且提供了解理性药物设计的手段。 从患者身上检查各种来源的组织，以了解AR机制（移植物活检），以及通过最小侵入性手段（血液）或非侵入性手段（尿同种异体移植物的尿液）进行监测。 对于生物标志物发现，检查不同类别的标记物，例如基因，蛋白质，肽和抗体。 这些生物标志物可以帮助确定受试者的移植类别（例如急性同种异体移植排斥（AR），稳定的同种异体移植物（STA），BK病毒血症，BK肾炎，药物毒性或慢性同种异体移植物损伤（CAI）等）。 还提供了用于实践主题方法的组合物，系统，试剂盒和计算机程序产品。 这些方法和组合物可用于各种应用。
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公开(公告)号：US09535075B2
公开(公告)日：2017-01-03
申请号：US13635667
申请日：2011-03-25
申请人： Minnie M. Sarwal , Tara Sigdel , Amit Kaushal , Li Li , Wenzhong Xiao , Atul J. Butte , Purvesh Khatri
发明人： Minnie M. Sarwal , Tara Sigdel , Amit Kaushal , Li Li , Wenzhong Xiao , Atul J. Butte , Purvesh Khatri
CPC分类号： G01N33/6893 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , G01N2800/245
摘要： Aspects of the present invention include methods for determining a transplant category of a subject having a transplant. Common mechanisms of rejection injury are uncovered across different tissue transplants, and provide a means to understand rational drug design. Various sources of tissues are examined form the patient for understanding AR mechanism (graft biopsy), as well as monitoring by minimal invasive means (blood) or non-invasive means (urine for the kidney allograft). For biomarker discovery different categories of markers are examined such as genes, proteins, peptides and antibodies. These biomarkers can help determine the subject's transplant category (e.g., acute allograft rejection (AR), stable allograft (STA), BK viremia, BK nephritis, drug toxicity or chronic allograft injury (CAI), and the like). Also provided are compositions, systems, kits and computer program products that find use in practicing the subject methods. The methods and compositions find use in a variety of applications.
摘要翻译： 本发明的方面包括用于确定具有移植物的受试者的移植类别的方法。 排除损伤的常见机制在不同的组织移植中被发现，并且提供了解理性药物设计的手段。 从患者身上检查各种来源的组织，以了解AR机制（移植物活检），以及通过最小侵入性手段（血液）或非侵入性手段（尿同种异体移植物的尿液）进行监测。 对于生物标志物发现，检查不同类别的标记物，例如基因，蛋白质，肽和抗体。 这些生物标志物可以帮助确定受试者的移植类别（例如急性同种异体移植排斥（AR），稳定的同种异体移植物（STA），BK病毒血症，BK肾炎，药物毒性或慢性同种异体移植物损伤（CAI）等）。 还提供了用于实践主题方法的组合物，系统，试剂盒和计算机程序产品。 这些方法和组合物可用于各种应用。
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公开(公告)号：US20140051597A1
公开(公告)日：2014-02-20
申请号：US14001825
申请日：2012-04-06
申请人： Minnie M. Sarwal , Tara Sigdel
发明人： Minnie M. Sarwal , Tara Sigdel
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , G01N33/564 , G01N2800/042
摘要： Methods are provided for determining whether a subject has a diabetes phenotype. In practicing the subject methods, a sample, e.g., a blood sample, from a subject is analyzed for the presence of one or more autoantibodies to obtain an antibody signature. The obtained antibody signature is then employed to determine whether the subject has a diabetes phenotype. The subject methods may be used in diagnostic or prognostic applications, e.g., determining whether the subject has diabetes (e.g., T1D or T2D), or monitoring a subject with diabetes to determine whether the subject has or will develop ESRD. Also provided are compositions, systems and kits that find use in practicing the subject methods. The subject methods and compositions find use in a variety of applications, including the diagnosis and monitoring of diabetes in a subject.
摘要翻译： 提供了用于确定受试者是否具有糖尿病表型的方法。 在实施本发明方法时，分析来自受试者的样品，例如血液样品中是否存在一种或多种自身抗体以获得抗体特征。 然后使用获得的抗体特征来确定受试者是否具有糖尿病表型。 主题方法可以用于诊断或预后应用，例如，确定受试者是否患有糖尿病（例如，T1D或T2D）或监测患有糖尿病的受试者以确定受试者是否具有或将发展ESRD。 还提供了用于实践主题方法的组合物，系统和试剂盒。 主题方法和组合物可用于各种应用，包括对受试者的糖尿病的诊断和监测。
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公开(公告)号：US20120283123A1
公开(公告)日：2012-11-08
申请号：US13508013
申请日：2010-11-24
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N33/6851 , G01N2800/245 , G01N2800/347 , G01N2800/56 , G01N2800/60
摘要： Methods are provided for determining a transplant category of a subject having a kidney graft. In practicing one aspect of the subject methods, the peptide signature of a non-invasive sample derived from the transplant subject (e.g., a urine sample) is used to determine the subject's transplant category (e.g., acute allograft rejection (AR), stable allograft (STA), BK virus nephropathy (BK), and the like). In other embodiments, a gene expression signature from a biopsy sample from the subject (e.g., mRNA level) is used to determine the subject's transplant category. In certain embodiments both a peptide signature and a gene expression signature are used. Also provided are compositions, systems, kits and computer program products that find use in practicing the subject methods.
摘要翻译： 提供了用于确定具有肾移植物的受试者的移植类别的方法。 在实施本发明方法的一个方面中，使用衍生自移植受试者的非侵入性样品（例如，尿样）的肽标签来确定受试者的移植类别（例如，急性同种异体移植排斥（AR），稳定的同种异体移植 （STA），BK病毒性肾病（BK）等）。 在其他实施方案中，使用来自受试者的活组织检查样品（例如mRNA水平）的基因表达特征来确定受试者的移植类别。 在某些实施方案中，使用肽标签和基因表达标签。 还提供了用于实践主题方法的组合物，系统，试剂盒和计算机程序产品。
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公开(公告)号：US20120165207A1
公开(公告)日：2012-06-28
申请号：US13148458
申请日：2010-02-12
申请人： Atul J. Butte , Rong Chen , Minnie M. Sarwal , Tara Sigdel
发明人： Atul J. Butte , Rong Chen , Minnie M. Sarwal , Tara Sigdel
IPC分类号： G01N33/566 , C40B30/04
CPC分类号： G01N33/6893 , G01N2333/521 , G01N2333/70503 , G01N2333/70585 , G01N2800/245
摘要： Methods are provided for monitoring an allograft recipient for a rejection response, e.g., to predict, to diagnose, and/or to characterize a rejection response. In practicing the subject methods, the level of at least one protein in a sample from the allograft recipient, e.g., serum, urine, blood, CSF, tears or saliva, is evaluated, to monitor the subject. Also provided are compositions, systems, and kits that find use in practicing the subject methods.
摘要翻译： 提供了用于监测同种异体移植受体以获得排斥反应的方法，例如预测，诊断和/或表征拒绝反应。 在实施本发明方法中，评价来自同种异体移植物受体（例如血清，尿液，血液，CSF，泪液或唾液）的样品中至少一种蛋白质的水平，以监测受试者。 还提供了用于实践主题方法的组合物，系统和试剂盒。
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8.再颁专利公开(公告)号：USRE47057E1
公开(公告)日：2018-09-25
申请号：US13529768
申请日：2012-06-21
IPC分类号： C12Q1/68 , G01N33/53 , C12Q1/6883 , C12Q1/6876
摘要： Methods are provided for evaluating a subject for graft survival, e.g., in terms of predicting graft survival, identifying the presence of a deleterious graft condition, such as CAN and DT, identifying the severity and class of acute rejection, etc, in a subject are provided. In practicing the subject methods, the expression of at least one gene in a sample from the subject, e.g., a blood or biopsy sample, is assayed, e.g., at the nucleic acid and/or protein level, to evaluate the subject. Also provided are compositions, systems and kits that find use in practicing the subject methods. The methods and compositions find use in a variety of applications.
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9.发明授权Methods and compositions for determining a graft tolerant phenotype in a subject 有权用于确定受试者的移植物耐受性表型的方法和组合物公开(公告)号：US08932808B1
公开(公告)日：2015-01-13
申请号：US10585610
申请日：2005-01-20
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： Methods are provided for determining whether a subject has a graft tolerant phenotype. In practicing the subject methods, the expression of at least one gene in a sample from the subject, e.g., a blood sample, is assayed to obtain an expression evaluation for the at least one gene. The obtained expression evaluation is then employed to determine whether the subject has a graft tolerant phenotype. Also provides are compositions, systems and kits that find use in practicing the subject methods. The methods and compositions find use in a variety of applications, including the determination of an immunosuppressive therapy regimen.
摘要翻译： 提供了用于确定受试者是否具有移植物耐受性表型的方法。 在实施本发明的方法中，测定来自受试者的样品（例如血液样品）中至少一种基因的表达，以获得至少一种基因的表达评估。 然后使用获得的表达评估来确定受试者是否具有接受耐受性表型。 还提供可用于实践主题方法的组合物，系统和试剂盒。 该方法和组合物可用于各种应用，包括测定免疫抑制治疗方案。
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公开(公告)号：US09290813B2
公开(公告)日：2016-03-22
申请号：US13512539
申请日：2010-12-01
申请人： Minnie M. Sarwal , Li Li , Samuel Strober
发明人： Minnie M. Sarwal , Li Li , Samuel Strober
CPC分类号： C12Q1/6883 , C12Q1/6888 , C12Q2600/106 , C12Q2600/158 , G01N33/6893 , G01N2800/245 , G01N2800/52
摘要： Methods are provided for determining whether a subject has a graft tolerant phenotype. In practicing the subject methods, the expression level of one or more gene in a sample from the subject, e.g., a blood sample, is assayed to obtain a gene expression result, where the gene expression result includes a result for a biomarker of graft tolerance. The obtained gene expression result is then employed to determine whether the subject has a graft tolerant phenotype. Also provided are compositions, systems and kits that find use in practicing the subject methods. The methods and compositions find use in a variety of applications, including the determination of an immunosuppressive therapy regimen.
摘要翻译： 提供了用于确定受试者是否具有移植物耐受性表型的方法。 在实施本发明方法中，测定来自受试者的样品（例如血液样品）中的一种或多种基因的表达水平以获得基因表达结果，其中基因表达结果包括用于接种耐药性的生物标志物的结果 。 然后使用获得的基因表达结果来确定受试者是否具有接受耐受性表型。 还提供了用于实践主题方法的组合物，系统和试剂盒。 该方法和组合物可用于各种应用，包括测定免疫抑制治疗方案。
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