公开(公告)号：US11993595B2

公开(公告)日：2024-05-28

申请号：US17901390

申请日：2022-09-01

Applicant: Mission Therapeutics Limited

Inventor： Alison Jones ,  Mark Ian Kemp ,  Martin Lee Stockley ,  Karl Richard Gibson ,  Gavin Alistair Whitlock ,  Andrew Madin

IPC: C07D417/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

CPC classification number: C07D417/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

公开(公告)号：US20200369658A1

公开(公告)日：2020-11-26

申请号：US16990150

申请日：2020-08-11

Applicant: Mission Therapeutics Limited

Inventor： Alison Jones ,  Mark Ian Kemp ,  Martin Lee Stockley ,  Karl Richard Gibson ,  Gavin Alistair Whitlock ,  Andrew Madin

IPC: C07D417/12 ,  C07D403/12 ,  C07D401/12 ,  C07D413/12 ,  C07D417/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

公开(公告)号：US20230052191A1

公开(公告)日：2023-02-16

申请号：US17901390

申请日：2022-09-01

Applicant: Mission Therapeutics Limited

Inventor： Alison Jones ,  Mark Ian Kemp ,  Martin Lee Stockley ,  Karl Richard Gibson ,  Gavin Alistair Whitlock ,  Andrew Madin

IPC: C07D417/12 ,  C07D403/12 ,  C07D401/12 ,  C07D413/12 ,  C07D417/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

公开(公告)号：US11472798B2

公开(公告)日：2022-10-18

申请号：US16990150

申请日：2020-08-11

Applicant: Mission Therapeutics Limited

Inventor： Alison Jones ,  Mark Ian Kemp ,  Martin Lee Stockley ,  Karl Richard Gibson ,  Gavin Alistair Whitlock ,  Andrew Madin

IPC: C07D417/12 ,  C07D403/12 ,  C07D401/12 ,  C07D413/12 ,  C07D417/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

公开(公告)号：US10683269B2

公开(公告)日：2020-06-16

申请号：US16080506

申请日：2017-03-17

Applicant: MISSION THERAPEUTICS LIMITED

Inventor： Karl Richard Gibson ,  Alison Jones ,  Mark Ian Kemp ,  Andrew Madin ,  Martin Lee Stockley ,  Gavin Alistair Whitlock ,  Michael D Woodrow ,  Keith Allan Menear

IPC: C07D209/44 ,  C07D403/10 ,  C07D403/04 ,  C07D401/04 ,  C07D471/04 ,  C07D413/04 ,  C07D401/12 ,  C07D413/12 ,  C07D409/12 ,  A61P35/00 ,  C07D519/00 ,  C07D403/14 ,  C07D487/04 ,  C07D401/06 ,  C07D405/12 ,  C07D401/14 ,  C07D413/14 ,  C07D413/10 ,  C07D403/12 ,  C07D417/12

Abstract: The invention relates to novel compounds of formula I which are inhibitors of deubiquitylating enzymes (DUBs) and/or desumoylating enzymes. In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 7 or ubiquitin specific peptidase 7 (USP7). The invention further relates to methods for the preparation of these compounds and to their use in the treatment of cancer.