公开(公告)号：US5629456A

公开(公告)日：1997-05-13

申请号：US350459

申请日：1994-12-07

申请人： Mitsuaki Yamada ,  Katsuhide Okimi ,  Katsuyuki Takahashi ,  Norio Nagano

发明人： Mitsuaki Yamada ,  Katsuhide Okimi ,  Katsuyuki Takahashi ,  Norio Nagano

IPC分类号： B01J31/02 ,  C07B61/00 ,  C07C41/30 ,  C07C41/40 ,  C07C43/23 ,  C07C39/12

CPC分类号： C07C43/23 ,  C07C2103/18

摘要： A fluorene derivative of high purity is produced by reacting fluorenone with phenoxyethanol in the presence of a sulfuric acid-thiol catalyst system, dissolving the reaction mixture in a lower aliphatic alcohol and adding water to the resulting solution for precipitation of 9,9-bis(4-(2-hydroxyethoxy)phenyl)fluorene [fluorene derivative]. A fluorene derivative of still higher purity is obtained by recrystallization from a lower aliphatic alcohol.In accordance with this invention, a fluorene derivative can be produced advantageously on a commercial scale without incurring any appreciable loss of fluorenone, in good yield, with high efficiency and in a reduced production time.

摘要翻译： 通过在硫酸 - 硫醇催化剂体系的存在下使芴酮与苯氧基乙醇反应制备高纯度的芴衍生物，将反应混合物溶解在低级脂族醇中，向所得溶液中加入9,9-双（ 4-（2-羟基乙氧基）苯基）芴[芴衍生物]。 通过从低级脂族醇重结晶获得更高纯度的芴衍生物。 根据本发明，可以以商业规模有利地生产芴衍生物，而不会以良好的产率，高效率和缩短的生产时间引起芴酮的明显损失。