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公开(公告)号：US20240268747A1
公开(公告)日：2024-08-15
申请号：US18290313
申请日：2021-05-18
发明人： Shun TONOOKA , Kota NOMURA , Kazuki YAMAUCHI , Tetsuya MATSUDA , Takami TOMIYAMA , Tomohiro UMEDA , Satoshi SEINO , Toshiyasu SAKANE , Akiko KATSUMI , Toshihiko KIWA , Akihiro IZAWA
IPC分类号： A61B5/00 , A61B5/0515
CPC分类号： A61B5/4088 , A61B5/0042 , A61B5/0515
摘要： A biological information detection device includes an administration mechanism (10) to administer magnetic particles into a brain, the magnetic particles being bound to a target inside the brain, a first varying magnetic field application mechanism (12a, 12b) to apply a first varying magnetic field to the magnetic particles from outside the brain, a magnetic signal detection mechanism (13a, 13b) to detect a magnetic signal generated by the magnetic particles bound to the target due to the first varying magnetic field, and a determiner (14) to determine an amount of the target based on a strength of the magnetic signal.
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公开(公告)号：US20220244327A1
公开(公告)日：2022-08-04
申请号：US17625774
申请日：2020-07-17
发明人： Tomokazu OGOMI , Kazuki YAMAUCHI
摘要： A magnetic sensor device includes a magnet that generates a magnetic field and sets of magnetoresistive elements arranged in a longitudinal direction that is perpendicular to a transport direction. Each of the sets of magnetoresistive elements includes a first and a second resistor. A midpoint of the first and the second resistor is matched with a center axis of the magnet in the transport direction. The first and the second resistor are arranged such that the distance therebetween increases from a distance between first ends of the first and the second resistor in the longitudinal direction to a distance between second ends of the first and the second resistor in the longitudinal direction. At least two sets of the first and the second resistor are arranged so as to be axisymmetric with respect to an imaginary line that is perpendicular to the longitudinal direction of the magnet.
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公开(公告)号：US20240201287A1
公开(公告)日：2024-06-20
申请号：US18287023
申请日：2021-04-22
发明人： Kazuki YAMAUCHI
IPC分类号： G01R33/12 , G01N33/543
CPC分类号： G01R33/1276 , G01N33/54333 , G01N33/54373
摘要： A detection method for detecting a detection target magnetic particle using an AC excitation magnetic field, the detection method includes: acquiring a Neel relaxation curve indicating a relationship between a Neel relaxation time and a particle diameter for candidate magnetic particles; acquiring a Brownian relaxation curve indicating a relationship between a Brownian relaxation time and the particle diameter for the candidate magnetic particles; specifying a particle diameter corresponding to an intersection of the Neel relaxation curve and the Brownian relaxation curve as an intersection particle diameter; and selecting a candidate magnetic particle having a particle diameter larger than the intersection particle diameter as the detection target magnetic particle.
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公开(公告)号：US20230184862A1
公开(公告)日：2023-06-15
申请号：US17912042
申请日：2020-04-16
发明人： Kota NOMURA , Kodai KATAGIRI , Tetsuya MATSUDA , Shun TONOOKA , Kazuki YAMAUCHI
IPC分类号： G01R33/563 , G01R33/3815
CPC分类号： G01R33/56375 , G01R33/3815 , G01R33/3804
摘要： A static magnetic field generator generates a non-magnetic field region. An AC magnetic field application instrument applies an AC magnetic field to the non-magnetic field region. A detection coil has an axis parallel to a direction of the AC magnetic field in order to detect a magnetization signal. A measuring instrument is connected to the detection coil. A resonance frequency variable device includes a capacitor connected in parallel to the detection coil in order to adjust a resonance frequency of the detection coil and the measuring instrument. A capacity of the capacitor is adjusted such that a resonance frequency of a closed circuit including the detection coil, the measuring instrument, and the resonance frequency variable device including the capacitor coincides with a frequency of a harmonic signal.
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公开(公告)号：US20230099731A1
公开(公告)日：2023-03-30
申请号：US17483809
申请日：2021-09-24
发明人： Kazuki YAMAUCHI , Chungwei LIN
摘要： A magnetic particle imaging system includes a field free region generator and an excited magnetic field generator. The field free region generator generates a field free line with a direction of linear extension of a field free region as a direction of extension. The excited magnetic field generator generates an excited magnetic field in the field free line generated by the field free region generator. The excited magnetic field generator includes a first excited magnetic field generation unit and a second excited magnetic field generation unit. The first excited magnetic field generation unit and the second excited magnetic field generation unit are spaced from each other in the direction of extension of the field free line.
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公开(公告)号：US20240111007A1
公开(公告)日：2024-04-04
申请号：US18285495
申请日：2022-03-29
发明人： Kota NOMURA , Tetsuya MATSUDA , Kazuki YAMAUCHI , Masaomi WASHINO
IPC分类号： G01R33/12
CPC分类号： G01R33/1276
摘要： A pair of first measurement coils is disposed so as to sandwich magnetic particles. A pair of second measurement coils is disposed so as to sandwich magnetic particles and the pair of first measurement coils. A pair of alternate-current magnetic field application coils is disposed so as to sandwich magnetic particles, the pair of first measurement coils, and the pair of second measurement coils. A measurement device outputs a signal representing a difference between a signal measured by the pair of first measurement coils and a signal measured by the pair of second measurement coils.
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公开(公告)号：US20230118954A1
公开(公告)日：2023-04-20
申请号：US17916076
申请日：2021-02-17
发明人： Tomokazu OGOMI , Kazuki YAMAUCHI , Kenji SHIMOHATA
摘要： A first magnetic field generator generates a magnetic field intersecting a detection object being transported along a transport path. A second magnetic field generator opposite to the first magnetic field generator with respect to the transport path generates a magnetic field intersecting the detection object. A first magnetoresistive element between the first magnetic field generator and the transport path outputs, as a change in resistance, a change in magnetic flux density produced by transport of the detection object. The first and second magnetic field generators are different in a magnetic pole facing the transport path and are arranged with a center of the first magnetic field generator in a transport direction of the detection object and a center of the second magnetic field generator in the transport direction are located at mutually different positions. The first magnetoresistive element includes a first resistor and a second resistor arranged with spacing therebetween.
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