公开(公告)号：US20210308031A1

公开(公告)日：2021-10-07

申请号：US17269123

申请日：2019-08-16

Applicant: Modern Meadow, inc.

Inventor： Lixin DAI ,  Poonarn SRIVASTAVA

IPC: A61K8/66 ,  A61K8/65 ,  C12N9/02 ,  C12N1/16 ,  A61K8/9728 ,  A61Q19/00

Abstract: The disclosure herein provides a fusion protein comprising prolyl 4-hydroxylase alpha subunit (P4HA) and a soluble protein partner. A fusion protein comprising prolyl 4-hydroxylase alpha subunit (P4HA1) and prolyl 4-hydroxylase beta subunit (P4HB) is provided. A microorganism including a fusion protein comprising prolyl 4-hydroxylase alpha subunit-1 (P4HA1) and prolyl 4-hydroxylase beta subunit (P4HB) is provided. The disclosure provides a microorganism including a fusion protein comprising prolyl 4-hydroxylase alpha subunit-1 (P4HA1) and prolyl 4-hydroxylase beta subunit (P4HB); and another protein to be hydroxylated. A method for providing skincare benefits including applying the fusion protein of the present disclosure on skin is also taught.