公开(公告)号：US11980672B2

公开(公告)日：2024-05-14

申请号：US17844877

申请日：2022-06-21

申请人： ModernaTX, Inc.

发明人： David H. Burkhardt ,  Romesh R. Subramanian ,  Christian Cobaugh

IPC分类号： A61K48/00 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61P1/16 ,  A61P31/14 ,  C12N15/10 ,  C12N15/67 ,  C12Q1/68

CPC分类号： A61K48/0058 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K48/0066 ,  A61P1/16 ,  A61P31/14 ,  C12N15/1086 ,  C12N15/67 ,  C12N2840/00

摘要： mRNAs containing an exogenous open reading frame (ORF) flanked by a 5′ untranslated region (UTR) and a 3′ UTR is provided, wherein the 5′ and 3′ UTRs are derived from a naturally abundant mRNA in a tissue. Also provided are methods for identifying the 5′ and 3′ UTRs, and methods for making and using the mRNAs.

公开(公告)号：US20230050143A1

公开(公告)日：2023-02-16

申请号：US17844877

申请日：2022-06-21

申请人： ModernaTX, Inc.

发明人： David H. Burkhardt ,  Romesh R. Subramanian ,  Christian Cobaugh

IPC分类号： A61K48/00 ,  C12N15/10 ,  C12N15/67 ,  A61P1/16 ,  A61P31/14 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125

摘要： mRNAs containing an exogenous open reading frame (ORF) flanked by a 5′ untranslated region (UTR) and a 3′ UTR is provided, wherein the 5′ and 3′ UTRs are derived from a naturally abundant mRNA in a tissue. Also provided are methods for identifying the 5′ and 3′ UTRs, and methods for making and using the mRNAs.

公开(公告)号：US20190307857A1

公开(公告)日：2019-10-10

申请号：US15781881

申请日：2016-12-09

申请人： ModernaTX, Inc.

发明人： Melissa Lasaro ,  David Osterman ,  Haren Vasavada ,  Christian Cobaugh

IPC分类号： A61K38/45 ,  A61K31/7115 ,  C12N15/52 ,  A61P3/00 ,  A61K31/7105

摘要： The invention relates to methods and compositions for treating a UDP glucuronosyltransferase family 1 deficiency based on mRNA therapy.

公开(公告)号：US20180353618A1

公开(公告)日：2018-12-13

申请号：US15781827

申请日：2016-12-09

申请人： ModernaTX, Inc.

发明人： David H. Burkhardt ,  Romesh R. Subramanian ,  Christian Cobaugh

IPC分类号： A61K48/00 ,  C12N15/10 ,  C12N15/67 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61P1/16 ,  A61P31/14

CPC分类号： A61K48/0058 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K48/0066 ,  A61P1/16 ,  A61P31/14 ,  C12N15/1086 ,  C12N15/67 ,  C12N2840/00

摘要： mRNAs containing an exogenous open reading frame (ORF) flanked by a 5′ untranslated region (UTR) and a 3′ UTR is provided, wherein the 5′ and 3′ UTRs are derived from a naturally abundant mRNA in a tissue. Also provided are methods for identifying the 5′ and 3′ UTRs, and methods for making and using the mRNAs.