公开(公告)号：US20220031631A1

公开(公告)日：2022-02-03

申请号：US17277423

申请日：2019-09-19

Applicant: ModernaTX, Inc.

Inventor： Örn Almarsson ,  Jin Lim ,  Eugene Cheung ,  Jaclyn Milton

IPC: A61K9/51 ,  A61K8/86 ,  C08G65/332

Abstract: The present disclosure is based, at least in part, on the discovery that high-purity PEG lipids exhibit superior physical and biological properties, particularly when used in lipid nanoparticle (LNP) formulations. Therefore, the present disclosure provides PEG lipids at a recommended purity, e.g., for use in formulations, such as LNP formulations. The present disclosure also provides LNPs comprising the high-purity PEG lipids, and methods for delivering therapeutic agents to a subject using the same.