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公开(公告)号：US20200306191A1
公开(公告)日：2020-10-01
申请号：US16643037
申请日：2018-08-31
Applicant: ModernaTX, Inc.
Inventor： Joseph SCHARITER , Kimberly HASSETT , Mike SMITH , Orn ALMARSSON , Luis BRITO
Abstract: The disclosure features novel methods of producing nucleic acid lipid nanoparticle (LNP) compositions employing a modifying agent after formation of a precursor nucleic acid lipid nanoparticle, the produced compositions thereof, and methods involving the nucleic acid lipid nanoparticles useful in the delivery of therapeutics and/or prophylactics, such as a nucleic acid, to mammalian cells or organs to, for example, to regulate polypeptide, protein, or gene expression.
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