公开(公告)号：US20220062175A1

公开(公告)日：2022-03-03

申请号：US17424780

申请日：2020-01-31

Applicant: ModernaTX, Inc.

Inventor： Mike SMITH ,  Allen HORHOTA ,  Jason AUER ,  Brie SKINNER

IPC: A61K9/127 ,  A61K48/00 ,  A61K9/51

Abstract: The present disclosure provides methods of producing lipid nanoparticle (LNP) formulations and the produced LNP formulations thereof. The present disclosure also provides therapeutic and diagnostic uses related to the produced LNP formulations.

公开(公告)号：US20200306191A1

公开(公告)日：2020-10-01

申请号：US16643037

申请日：2018-08-31

Applicant: ModernaTX, Inc.

Inventor： Joseph SCHARITER ,  Kimberly HASSETT ,  Mike SMITH ,  Orn ALMARSSON ,  Luis BRITO

IPC: A61K9/19 ,  A61K47/60

Abstract: The disclosure features novel methods of producing nucleic acid lipid nanoparticle (LNP) compositions employing a modifying agent after formation of a precursor nucleic acid lipid nanoparticle, the produced compositions thereof, and methods involving the nucleic acid lipid nanoparticles useful in the delivery of therapeutics and/or prophylactics, such as a nucleic acid, to mammalian cells or organs to, for example, to regulate polypeptide, protein, or gene expression.

公开(公告)号：US20200069599A1

公开(公告)日：2020-03-05

申请号：US16310026

申请日：2017-06-14

Applicant: ModernaTX, Inc.

Inventor： Mike SMITH ,  Orn ALMARSSON ,  Luis BRITO

IPC: A61K9/51 ,  A61K9/19 ,  A61K9/127 ,  A61K48/00 ,  A61K31/7105 ,  A61K47/26

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles further including therapeutics and/or prophylactics such as RNA are useful in the delivery of therapeutics and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.