公开(公告)号：US20250092440A1

公开(公告)日：2025-03-20

申请号：US18294279

申请日：2022-08-01

Applicant: ModernaTX, Inc.

Inventor： Meredith Packer ,  Kevin Cognata

IPC: C12Q1/6811 ,  B01D15/32

Abstract: Aspects of the disclosure relate to liquid chromatography (e.g., HPLC) methods which enable identification of one or more target nucleic acids in a mixture (e.g., pharmaceutical composition). The disclosure is based, in part, on methods that allow for addition of pharmaceutical compositions (e.g., lipid-based pharmaceutical compositions) directly onto a chromatographic column without the need for first separating target nucleic acids out of the composition. Accordingly, in some embodiments, methods described by the disclosure are useful for assessing the quality of pharmaceutical preparations comprising nucleic acids.