公开(公告)号：US20250144036A1

公开(公告)日：2025-05-08

申请号：US18716220

申请日：2022-12-09

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Juneyoung LEE ,  Mohindra SEEPERSAUD

IPC: A61K9/51 ,  C07C229/06

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel cationic lipid as well as additional lipids such as ionizable lipids, phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20240226026A1

公开(公告)日：2024-07-11

申请号：US18551704

申请日：2022-03-23

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Mark CORNEBISE ,  Edward HENNESSY ,  Mohindra SEEPERSAUD ,  Michael W. DANNEMAN

IPC: A61K9/51 ,  C07C233/36 ,  C07C233/62 ,  C07C233/78 ,  C07C311/32 ,  C07D205/04 ,  C07D207/16 ,  C07D213/74 ,  C07D231/12 ,  C07D271/07 ,  C07D285/10 ,  C07D307/24 ,  C07D309/08

CPC classification number: A61K9/5123 ,  C07C233/36 ,  C07C233/62 ,  C07C233/78 ,  C07C311/32 ,  C07D205/04 ,  C07D207/16 ,  C07D213/74 ,  C07D231/12 ,  C07D271/07 ,  C07D285/10 ,  C07D307/24 ,  C07D309/08

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.