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公开(公告)号：US12042527B2
公开(公告)日：2024-07-23
申请号：US16736941
申请日：2020-01-08
Applicant: ModernaTX, Inc.
Inventor： Robert Meehan , Tal Zaks
CPC classification number: A61K38/20 , A61K9/0019 , A61K9/5123 , A61K38/191 , A61K39/3955 , A61K39/39558 , A61P35/00
Abstract: The disclosure features methods for treating solid tumor malignancies and lymphomas by administering LNP encapsulated mRNAs encoding human OX40L, IL-23 and IL-36γ polypeptides alone or in combination with checkpoint blockade. The disclosure also features compositions for use in the methods.
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