公开(公告)号：US11278611B2

公开(公告)日：2022-03-22

申请号：US16850519

申请日：2020-04-16

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K39/015 ,  A61P11/00 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/39 ,  A61K39/42 ,  A61K48/00 ,  A61K39/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US20200289639A1

公开(公告)日：2020-09-17

申请号：US16853973

申请日：2020-04-21

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/015 ,  A61P11/00 ,  A61K39/39 ,  A61K39/42 ,  A61K48/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US10675342B2

公开(公告)日：2020-06-09

申请号：US16136503

申请日：2018-09-20

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K39/015 ,  A61K39/39 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61P11/00 ,  A61K39/42 ,  A61K48/00 ,  A61K39/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US20190008947A1

公开(公告)日：2019-01-10

申请号：US16136503

申请日：2018-09-20

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K9/127 ,  A61K9/51 ,  A61K39/015 ,  A61K39/39 ,  A61K39/42 ,  A61K9/00 ,  A61K39/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US12150980B2

公开(公告)日：2024-11-26

申请号：US15748773

申请日：2016-07-29

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Nicholas Valiante ,  Tal Zaks

IPC: C12N15/63 ,  A61K9/127 ,  A61K39/00 ,  A61K45/06 ,  A61K47/26 ,  A61K47/54 ,  A61K47/68 ,  A61P35/00 ,  C12N15/62

Abstract: The invention relates to concatemeric peptide epitope RNAs, as well as methods and compositions thereof. mRNA vaccines are also provided according to the invention, including cancer vaccines.

公开(公告)号：US12042527B2

公开(公告)日：2024-07-23

申请号：US16736941

申请日：2020-01-08

Applicant: ModernaTX, Inc.

Inventor： Robert Meehan ,  Tal Zaks

IPC: A61K38/20 ,  A61K9/00 ,  A61K9/51 ,  A61K38/19 ,  A61K39/395 ,  A61P35/00

CPC classification number: A61K38/20 ,  A61K9/0019 ,  A61K9/5123 ,  A61K38/191 ,  A61K39/3955 ,  A61K39/39558 ,  A61P35/00

Abstract: The disclosure features methods for treating solid tumor malignancies and lymphomas by administering LNP encapsulated mRNAs encoding human OX40L, IL-23 and IL-36γ polypeptides alone or in combination with checkpoint blockade. The disclosure also features compositions for use in the methods.

公开(公告)号：US11351242B1

公开(公告)日：2022-06-07

申请号：US16788182

申请日：2020-02-11

Applicant: ModernaTX, Inc.

Inventor： Lori Panther ,  Christine Shaw ,  Igor Smolenov ,  Michael Watson ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/51 ,  A61K39/00

Abstract: Provided herein are vaccine composition comprising a chemically-modified messenger ribonucleic acid (mRNA) encoding a hMPV fusion (F) glycoprotein and a chemically-modified mRNA encoding a hPIV3 F glycoprotein formulated in a cationic lipid nanoparticle formulation, and related method for inducing an antigen-specific immune response.

公开(公告)号：US10517940B2

公开(公告)日：2019-12-31

申请号：US16136386

申请日：2018-09-20

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/39 ,  A61K48/00 ,  A61K39/42 ,  A61K39/015 ,  A61K39/00

Abstract: The disclosure relates to Zika virus infection and the treatment thereof. The invention includes ribonucleic acid compositions, as well as methods of using the compositions for treating and preventing Zika virus infection.

公开(公告)号：US20180318409A1

公开(公告)日：2018-11-08

申请号：US15769710

申请日：2016-10-21

Applicant: ModernaTX, Inc.

Inventor： Nicholas Valiante ,  Tal Zaks ,  Eric Yi-Chun Huang ,  Giuseppe Ciaramella

IPC: A61K39/00 ,  A61K9/51 ,  A61K9/10 ,  A61P35/00

CPC classification number: A61K39/001114 ,  A61K9/10 ,  A61K9/5123 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55588 ,  A61P35/00

Abstract: The disclosure relates to cancer ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20240366745A1

公开(公告)日：2024-11-07

申请号：US18635203

申请日：2024-04-15

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/00 ,  A61K39/015 ,  A61K39/39 ,  A61K39/42 ,  A61K48/00 ,  A61P11/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.