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公开(公告)号：US5609866A
公开(公告)日：1997-03-11
申请号：US163609
申请日：1993-12-06
申请人： Mohammed A. Khan , John F. Moellmer
发明人： Mohammed A. Khan , John F. Moellmer
CPC分类号： A61K9/0014 , A61K31/79 , A61K33/18 , A61K47/10 , A61K47/48176
摘要： Sterilized povidone-iodine (polyvinylpyrrolidone-iodine) in an ointment form is obtained by preparation of a mixture of purified water, povidone-iodine, a non-ionic gelling agent, and a non-ionic low suds surfactant. The ointment is a liquid in the temperature range of about 2.degree. C. to 9.degree. C. because of the influence of the non-ionic gelling agent. At room temperature, the mixture forms a free standing ointment which can be sterilized by gamma radiation without degradation of its antimicrobial efficacy, viscosity or shelf life. The ointment is easily prepared by using chilled purified water which maintains the mixture as a liquid while all of the ingredients are mixed together. At room temperature the mixture becomes a free standing ointment.
摘要翻译： 通过制备纯化水，聚维酮碘，非离子胶凝剂和非离子低泡表面活性剂的混合物，得到软膏形式的灭活聚维酮碘（聚乙烯吡咯烷酮 - 碘）。 由于非离子胶凝剂的影响，软膏是在约2℃至9℃的温度范围内的液体。 在室温下，混合物形成自立式软膏，其可以通过γ辐射灭菌而不降低其抗菌效力，粘度或保质期。 通过使用冷冻纯化水容易地制备软膏，其将混合物保持为液体，同时将所有成分混合在一起。 在室温下，混合物成为独立软膏。
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公开(公告)号：US4904480A
公开(公告)日：1990-02-27
申请号：US245484
申请日：1988-09-19
申请人： Mohammed A. Khan , John F. Moellmer
发明人： Mohammed A. Khan , John F. Moellmer
IPC分类号： A61K9/08 , A01N59/12 , A61K8/00 , A61K8/20 , A61K8/23 , A61K31/79 , A61K33/18 , A61K33/34 , A61K47/02 , A61P17/00 , A61Q17/00
CPC分类号： A01N59/12
摘要： A germicidal iodine-containing composition includes iodine, an iodophor, cupric ions and nitrite ions in an aqueous base. Iodide ions which form in the composition during radiation sterilization or prolonged shelf life are oxidized back to iodine by the cupric ions in a Ph dependent reaction which consumes hydrogen ions formed concurrently with the iodide ions. Cuprous ions formed during the oxidation are spontaneously cycled back to cupric ions by traces of air present in the composition. The composition may include nitrite ions to augment the conversion of cuprous ions back to the cupric form.
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公开(公告)号：US5164107A
公开(公告)日：1992-11-17
申请号：US690316
申请日：1991-04-25
申请人： Mohammad A. Khan , John F. Moellmer
发明人： Mohammad A. Khan , John F. Moellmer
摘要： A cleansing composition particularly useful as a surgical scrub includes chlorhexidine gluconate and a nonylphenoxypoly(ethyleneoxy)ethanol surfactant in an aqueous vehicle, and may contain other surfactants, thickeners, emollients, dyes, perfumes and the like.
摘要翻译： 特别可用作手术洗刷的清洁组合物包括水性载体中的氯己定葡萄糖酸氯己定和壬基苯氧基聚（乙烯氧基）乙醇表面活性剂，并且可以含有其它表面活性剂，增稠剂，润肤剂，染料，香料等。
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公开(公告)号：US5116623A
公开(公告)日：1992-05-26
申请号：US643737
申请日：1991-01-22
申请人： Mohammad A. Khan , John F. Moellmer
发明人： Mohammad A. Khan , John F. Moellmer
摘要： A germicidal iodophor composition is disclosed having improved long term stability, by controlling the pH of the composition and supplementing the elemental iodine with a source of periodate. The present invention comprises an iodophor composition comprising periodate and having a pH of about 4.5 or below. Processes for making the iodophors, as well as methods for killing bacteria on a substrate using these germicidal iodophor compositions are also disclosed.
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