公开(公告)号：US20240013867A1

公开(公告)日：2024-01-11

申请号：US18119992

申请日：2023-03-10

申请人： Molecular Devices, LLC

发明人： Emmanuel Israel Fuentes ,  Gopal Biligeri Avinash ,  Robert John Graves ,  Abhijit Vijay Thatte ,  Afek Kodesh ,  Jeffery Caron ,  Sharmistha Das

IPC分类号： G16C20/50 ,  G06T7/00 ,  G16B20/00 ,  G06V20/69 ,  G06F18/00 ,  G06F18/2321 ,  G06V10/762

CPC分类号： G16C20/50 ,  G06T7/0012 ,  G16B20/00 ,  G06V20/698 ,  G06T7/0014 ,  G06F18/00 ,  G06F18/2321 ,  G06V10/763 ,  G06T2200/24 ,  G06T2207/30024 ,  G01N33/5008

摘要： The invention relates to a method for a computer device, for detecting an optimal candidate compound based on a plurality of samples comprising a cell line and one or more biomarkers, and a plate map configuration, wherein the plate map configuration is providing locations of samples comprising cell lines exposed to one or more biomarkers and different concentrations of a candidate compound forming at least one concentration gradient, the candidate compound being comprised in a plurality of candidate compounds, said method comprising generating (310) phenotypic profiles of each concentration gradient of each of the plurality of candidate compounds at a plurality of successive points in time to form a plurality of compound profiles, wherein generating phenotypic profiles comprises the steps obtaining (312) image data depicting each sample comprised in the concentration gradient, generating (314) a class-label and a class for each cell of the samples based on the image data, detecting (320) the optimal candidate compound by evaluating a comparison criterion on the plurality of compound profiles. Furthermore, the invention also relates to corresponding computer device, a computer program, and a computer program product.

公开(公告)号：US11636924B2

公开(公告)日：2023-04-25

申请号：US16336549

申请日：2017-10-02

申请人： Molecular Devices, LLC

发明人： Emmanuel Israel Fuentes ,  Gopal Biligeri Avinash ,  Robert John Graves ,  Abhijit Vijay Thatte ,  Afek Kodesh ,  Jeffery Caron ,  Sharmistha Das

IPC分类号： G16C20/50 ,  G06T7/00 ,  G16B20/00 ,  G06V20/69 ,  G06F18/00 ,  G06F18/2321 ,  G06V10/762 ,  G01N33/50

摘要： The invention relates to a method for a computer device, for detecting an optimal candidate compound based on a plurality of samples comprising a cell line and one or more biomarkers, and a plate map configuration, wherein the plate map configuration is providing locations of samples comprising cell lines exposed to one or more biomarkers and different concentrations of a candidate compound forming at least one concentration gradient, the candidate compound being comprised in a plurality of candidate compounds, said method comprising generating (310) phenotypic profiles of each concentration gradient of each of the plurality of candidate compounds at a plurality of successive points in time to form a plurality of compound profiles, wherein generating phenotypic profiles comprises the steps obtaining (312) image data depicting each sample comprised in the concentration gradient, generating (314) a class-label and a class for each cell of the samples based on the image data, detecting (320) the optimal candidate compound by evaluating a comparison criterion on the plurality of compound profiles. Furthermore, the invention also relates to corresponding computer device, a computer program, and a computer program product.