公开(公告)号：US20210340547A1

公开(公告)日：2021-11-04

申请号：US17365260

申请日：2021-07-01

Applicant: Monash University

Inventor： Siew Yeen Chai ,  Robert Widdop ,  Tracey Gaspari ,  Huey Wen Lee

IPC: C12N15/113 ,  A61K31/351 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/55 ,  A61P1/16 ,  A61P9/00 ,  A61P13/12 ,  A61K31/395

Abstract: The present invention relates to compositions, methods and kits for the treatment of fibrosis. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment of cardiac fibrosis. The invention provides a method of treating fibrosis in an individual comprising administering an inhibitor of insulin-regulated aminopeptidase (IRAP), thereby treating fibrosis.

公开(公告)号：US11078488B2

公开(公告)日：2021-08-03

申请号：US16984996

申请日：2020-08-04

Applicant: Monash University

Inventor： Siew Yeen Chai ,  Robert Widdop ,  Tracey Gaspari ,  Huey Wen Lee

IPC: A61K31/395 ,  A61K31/351 ,  A61K31/4433 ,  C12N15/113 ,  A61K31/4709 ,  A61K31/55 ,  A61P1/16 ,  A61P9/00 ,  A61P13/12

Abstract: The present invention relates to compositions, methods and kits for the treatment of fibrosis. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment of cardiac fibrosis. The invention provides a method of treating fibrosis in an individual comprising administering an inhibitor of insulin-regulated aminopeptidase (IRAP), thereby treating fibrosis.

公开(公告)号：US11331368B2

公开(公告)日：2022-05-17

申请号：US16630053

申请日：2018-07-17

Applicant: Monash University

Inventor： Robert Widdop ,  Marie-Isabel Aguilar ,  Mark Del Borgo ,  Emma Jones ,  Baydaa Hirmiz ,  Yan Wang

IPC: A61K38/08 ,  A61P17/02

Abstract: The present invention relates to compositions, methods and kits for the treatment of fibrosis. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment of cardiac fibrosis. The invention provides a method of treating fibrosis in an individual comprising administering an AT2R selective agonist, thereby treating fibrosis.

公开(公告)号：US20190249179A1

公开(公告)日：2019-08-15

申请号：US16123898

申请日：2018-09-06

Applicant: Monash University

Inventor： Siew Yeen Chai ,  Robert Widdop ,  Tracey Gaspari ,  Huey Wen Lee

IPC: C12N15/113 ,  A61P1/16 ,  A61K31/395 ,  A61P13/12 ,  A61P9/00 ,  A61K31/55 ,  A61K31/4709 ,  A61K31/4433 ,  A61K31/351

Abstract: The present invention relates to a method for the treatment of fibrosis, in particular cardiac fibrosis, comprising the administration of an inhibitor of insulin-regulated aminopeptidase (IRAP). Preferable the IRAP inhibitor is chosen from the group including HFI-419, HA-08, AL-40, HFI-437, Val-Tyr-Ile-His-Pro-Phe (otherwise known as angiotensin IV or ANG IV), c[Cys-Tyr-Cys]-His-Pro-Phe, and c[Hcy-Tyr-Hcy]-His-Pro-Phe.

公开(公告)号：US20240084308A1

公开(公告)日：2024-03-14

申请号：US18495512

申请日：2023-10-26

Applicant: Monash University

Inventor： Siew Yeen Chai ,  Robert Widdop ,  Tracey Gaspari ,  Huey Wen Lee

IPC: C12N15/113 ,  A61K31/351 ,  A61K31/395 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/55 ,  A61P1/16 ,  A61P9/00 ,  A61P13/12

CPC classification number: C12N15/1137 ,  A61K31/351 ,  A61K31/395 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/55 ,  A61P1/16 ,  A61P9/00 ,  A61P13/12 ,  C12N2310/14

Abstract: The present invention relates to compositions, methods and kits for the treatment of fibrosis. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment of cardiac fibrosis. The invention provides a method of treating fibrosis in an individual comprising administering an inhibitor of insulin-regulated aminopeptidase (IRAP), thereby treating fibrosis.

公开(公告)号：US11834663B2

公开(公告)日：2023-12-05

申请号：US17365260

申请日：2021-07-01

Applicant: Monash University

Inventor： Siew Yeen Chai ,  Robert Widdop ,  Tracey Gaspari ,  Huey Wen Lee

IPC: A61K31/395 ,  A61K31/351 ,  A61K31/4433 ,  A61P11/16 ,  A61P9/00 ,  A61P13/12 ,  C12N15/113 ,  A61K31/4709 ,  A61K31/55 ,  A61P1/16

CPC classification number: C12N15/1137 ,  A61K31/351 ,  A61K31/395 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/55 ,  A61P1/16 ,  A61P9/00 ,  A61P13/12 ,  C12N2310/14

Abstract: The present invention relates to compositions, methods and kits for the treatment of fibrosis. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment of cardiac fibrosis. The invention provides a method of treating fibrosis in an individual comprising administering an inhibitor of insulin-regulated aminopeptidase (IRAP), thereby treating fibrosis.

公开(公告)号：US10787668B2

公开(公告)日：2020-09-29

申请号：US16123898

申请日：2018-09-06

Applicant: Monash University

Inventor： Siew Yeen Chai ,  Robert Widdop ,  Tracey Gaspari ,  Huey Wen Lee

IPC: A61K31/395 ,  A61K31/351 ,  A61K31/4433 ,  C12N15/113 ,  A61K31/4709 ,  A61K31/55 ,  A61P1/16 ,  A61P9/00 ,  A61P13/12

Abstract: The present invention relates to a method for the treatment of fibrosis, in particular cardiac fibrosis, comprising the administration of an inhibitor of insulin-regulated aminopeptidase (IRAP). Preferable the IRAP inhibitor is chosen from the group including HFI-419, HA-08, AL-40, HFI-437, Val-Tyr-Ile-His-Pro-Phe (otherwise known as angiotensin IV or ANG IV), c[Cys-Tyr-Cys]-His-Pro-Phe, and c[Hcy-Tyr-Hcy]-His-Pro-Phe.

公开(公告)号：US10100311B2

公开(公告)日：2018-10-16

申请号：US15747697

申请日：2016-07-29

Applicant: Monash University

Inventor： Siew Yeen Chai ,  Robert Widdop ,  Tracey Gaspari ,  Huey Wen Lee

IPC: A61P1/16 ,  A61K31/395 ,  A61K31/351 ,  A61P13/12 ,  A61P9/00 ,  A61K31/4433 ,  C12N15/113

Abstract: The present invention relates to a method for the treatment of fibrosis, in particular cardiac fibrosis, comprising the administration of an inhibitor of insulin-regulated aminopeptidase (IRAP). Preferable the IRAP inhibitor is chosen from the group including HFI-419, HA-08, AL-40, HFI-437, Val-Tyr-Ile-His-Pro-Phe (otherwise known as angiotensin IV or ANG IV), c[Cys-Tyr-Cys]-His-Pro-Phe, and c[Hcy-Tyr-Hcy]-His-Pro-Phe.

公开(公告)号：US20180223287A1

公开(公告)日：2018-08-09

申请号：US15747697

申请日：2016-07-29

Applicant: Monash University

Inventor： Siew Yeen Chai ,  Robert Widdop ,  Tracey Gaspari ,  Huey Wen Lee

IPC: C12N15/113 ,  A61P9/00 ,  A61P13/12 ,  A61P1/16 ,  A61K31/4433 ,  A61K31/351 ,  A61K31/395

CPC classification number: C12N15/1137 ,  A61K31/351 ,  A61K31/395 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/55 ,  A61P1/16 ,  A61P9/00 ,  A61P13/12 ,  C12N2310/14

Abstract: The present invention relates to a method for the treatment of fibrosis, in particular cardiac fibrosis, comprising the administration of an inhibitor of insulin-regulated aminopeptidase (IRAP). Preferable the IRAP inhibitor is chosen from the group including HFI-419, HA-08, AL-40, HFI-437, Val-Tyr-Ile-His-Pro-Phe (otherwise known as angiotensin IV or ANG IV), c[Cys-Tyr-Cys]-His-Pro-Phe, and c[Hcy-Tyr-Hcy]-His-Pro-Phe.