公开(公告)号：US10655125B2

公开(公告)日：2020-05-19

申请号：US16080738

申请日：2017-03-03

Applicant: MorphoSys AG

Inventor： Roger Müller ,  Andreas Bültmann ,  Josef Prassler ,  Markus Moosmeier

IPC: C40B40/10 ,  C12N15/10 ,  C40B40/02

Abstract: The invention relates to novel polypeptide libraries that are conformationally constrained in an anti-parallel, helix-turn-helix arrangement. The invention further relates to methods of generating and screening such libraries for biological, pharmaceutical and other uses.

公开(公告)号：US11085038B2

公开(公告)日：2021-08-10

申请号：US16843299

申请日：2020-04-08

Applicant: MorphoSys AG

Inventor： Roger Müller ,  Andreas Bültmann ,  Josef Prassler ,  Markus Moosmeier

IPC: C40B40/10 ,  C12N15/10 ,  C40B40/02

Abstract: The invention relates to novel polypeptide libraries that are conformationally constrained in an anti-parallel, helix-turn-helix arrangement. The invention further relates to methods of generating and screening such libraries for biological, pharmaceutical and other uses.

公开(公告)号：US20200231963A1

公开(公告)日：2020-07-23

申请号：US16843299

申请日：2020-04-08

Applicant: MorphoSys AG

Inventor： Roger Müller ,  Andreas Bültmann ,  Josef Prassler ,  Markus Moosmeier

IPC: C12N15/10 ,  C40B40/02 ,  C40B40/10

Abstract: The invention relates to novel polypeptide libraries that are conformationally constrained in an anti-parallel, helix-turn-helix arrangement. The invention further relates to methods of generating and screening such libraries for biological, pharmaceutical and other uses.

公开(公告)号：US20190270981A1

公开(公告)日：2019-09-05

申请号：US16080738

申请日：2017-03-03

Applicant: MorphoSys AG

Inventor： Roger Müller ,  Andreas Bültmann ,  Josef Prassler ,  Markus Moosmeier

IPC: C12N15/10 ,  C40B40/10 ,  C40B40/02

Abstract: The invention relates to novel polypeptide libraries that are conformationally constrained in an anti-parallel, helix-turn-helix arrangement. The invention further relates to methods of generating and screening such libraries for biological, pharmaceutical and other uses.

公开(公告)号：US11472880B2

公开(公告)日：2022-10-18

申请号：US16635303

申请日：2018-08-13

Applicant: MORPHOSYS AG

Inventor： Thomas Tiller ,  Steffen Runz ,  Julia Neugebauer ,  Andreas Bültmann

IPC: C07K16/28 ,  C07K16/32

Abstract: The present disclosure provides humanized antibodies that specifically bind to CD3 with an optimized affinity and induce T cell-mediated killing of tumour related target antigen high expressing cells with high potency but have limited killing activity on target antigen low expressing cells. The present disclosure also provides bispecific antibodies comprising a first antigen-binding domain that specifically binds to human CD3 with optimized affinity and a second antigen-binding molecule that specifically binds a tumor-related antigen. The disclosure further relates to methods of generating such humanized antibodies and bispecific antibodies for biological, diagnostic, pharmaceutical and other uses.

公开(公告)号：US10815297B2

公开(公告)日：2020-10-27

申请号：US16184390

申请日：2018-11-08

Applicant: MorphoSys AG ,  Galapagos NV

Inventor： Andreas Bültmann ,  Robert Mühlbacher ,  Teresa Garcia ,  Reginald Christophe Xavier Brys ,  Luc Nelles ,  Katja Conrath

IPC: C07K16/24 ,  A61K39/395 ,  A61K39/00

Abstract: The present invention provides antagonists of IL17C for use in the treatment of an inflammatory disorder.

公开(公告)号：US20140243506A1

公开(公告)日：2014-08-28

申请号：US14351162

申请日：2012-10-19

Applicant: MorphoSys AG ,  Galapagos NV

Inventor： Andreas Bültmann ,  Robert Mühlbacher ,  Teresa Garcia ,  Reginald Christophe Xavier Brys ,  Luc Nelles ,  Katja Conrath

IPC: C07K16/24

CPC classification number: C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention provides antagonists of IL17C for use in the treatment of an inflammatory disorder.

Abstract translation: 本发明提供了用于治疗炎症性疾病的IL17C拮抗剂。