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公开(公告)号：US10655125B2
公开(公告)日：2020-05-19
申请号：US16080738
申请日：2017-03-03
Applicant: MorphoSys AG
Inventor： Roger Müller , Andreas Bültmann , Josef Prassler , Markus Moosmeier
Abstract: The invention relates to novel polypeptide libraries that are conformationally constrained in an anti-parallel, helix-turn-helix arrangement. The invention further relates to methods of generating and screening such libraries for biological, pharmaceutical and other uses.
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公开(公告)号：US20230399381A1
公开(公告)日：2023-12-14
申请号：US18326406
申请日：2023-05-31
Applicant: MORPHOSYS AG
Inventor： Thomas Tiller , Markus Waldhuber , Ralf Strohner , Kathrin Ladetzki-Baehs , Josef Prassler
CPC classification number: C07K16/005 , C07K16/18 , C07K2317/20 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/92 , C07K2317/94
Abstract: The present invention provides synthetic canine antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries.
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公开(公告)号：US20210317190A1
公开(公告)日：2021-10-14
申请号：US17237527
申请日：2021-04-22
Applicant: MORPHOSYS AG
Inventor： Thomas Tiller , Markus Waldhuber , Ralf Strohner , Kathrin Ladetzki-Baehs , Josef Prassler
Abstract: The present invention provides synthetic canine antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries.
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公开(公告)号：US11085038B2
公开(公告)日：2021-08-10
申请号：US16843299
申请日：2020-04-08
Applicant: MorphoSys AG
Inventor： Roger Müller , Andreas Bültmann , Josef Prassler , Markus Moosmeier
Abstract: The invention relates to novel polypeptide libraries that are conformationally constrained in an anti-parallel, helix-turn-helix arrangement. The invention further relates to methods of generating and screening such libraries for biological, pharmaceutical and other uses.
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公开(公告)号：US11014978B2
公开(公告)日：2021-05-25
申请号：US16624514
申请日：2018-06-21
Applicant: MORPHOSYS AG
Inventor： Thomas Tiller , Markus Waldhuber , Ralf Strohner , Kathrin Ladetzki-Baehs , Josef Prassler
Abstract: The present invention provides synthetic canine antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries.
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Patent Agency Ranking
公开(公告)号：US20200231963A1
公开(公告)日：2020-07-23
申请号：US16843299
申请日：2020-04-08
Applicant: MorphoSys AG
Inventor： Roger Müller , Andreas Bültmann , Josef Prassler , Markus Moosmeier
Abstract: The invention relates to novel polypeptide libraries that are conformationally constrained in an anti-parallel, helix-turn-helix arrangement. The invention further relates to methods of generating and screening such libraries for biological, pharmaceutical and other uses.
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公开(公告)号：US20170183395A1
公开(公告)日：2017-06-29
申请号：US15455582
申请日：2017-03-10
Applicant: MorphoSys AG
Inventor： Josef Prassler , David Ott , Stefanie Thiel , Yvonne Stark , Ute Keck , Thomas Pietzonka , Hilmar Ebersbach
CPC classification number: C07K16/005 , C07K16/00 , C07K16/22 , C07K16/243 , C07K2317/20 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , C07K2317/94 , G01N33/6854
Abstract: The present invention provides synthetic rodent antibody libraries, such as mouse or rat antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries and variants of such antibodies.
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公开(公告)号：US20170218048A1
公开(公告)日：2017-08-03
申请号：US15449561
申请日：2017-03-03
Applicant: MorphoSys AG
Inventor： Markus Enzelberger , Stefanie Urlinger , Thomas Tiller , Josef Prassler , Tanja Herrmann
CPC classification number: C07K16/005 , C07K16/00 , C07K16/32 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C12N15/1093 , C40B30/04 , C40B40/08 , C40B50/06
Abstract: The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having favorable biophysical properties. More specifically, the collections of the present disclosure comprise the most prevalent and/or preferred VH and VL class pairings with highly diversified CDRs.
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公开(公告)号：US20140163208A1
公开(公告)日：2014-06-12
申请号：US14169162
申请日：2014-01-31
Applicant: MorphoSys AG
Inventor： Markus Enzelberger , Stefanie Urlinger , Thomas Tiller , Josef Prassler , Tanja Herrmann
IPC: C07K16/00
CPC classification number: C07K16/005 , C07K16/00 , C07K16/32 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C12N15/1093 , C40B30/04 , C40B40/08 , C40B50/06
Abstract: The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having favorable biophysical properties. More specifically, the collections of the present disclosure comprise the most prevalent and/or preferred VH and VL class pairings with highly diversified CDRs.
Abstract translation: 本公开使得能够鉴定人免疫谱中的VH和VL类对的方法，确定最普遍的VH和VL类对以及具有有利的生物物理性质的那些。 更具体地，本公开的集合包含具有高度多样化的CDR的最普遍和/或优选的VH和VL类配对。
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公开(公告)号：US10647757B2
公开(公告)日：2020-05-12
申请号：US15449561
申请日：2017-03-03
Applicant: MorphoSys AG
Inventor： Markus Enzelberger , Stefanie Urlinger , Thomas Tiller , Josef Prassler , Tanja Herrmann
Abstract: The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having favorable biophysical properties. More specifically, the collections of the present disclosure comprise the most prevalent and/or preferred VH and VL class pairings with highly diversified CDRs.
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