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1.发明授权Compositions, articles and methods comprising TSPO ligands for preventing or reducing tobacco-associated damage 有权包含用于预防或减少烟草相关损伤的TSPO配体的组合物，制品和方法公开(公告)号：US08685962B2
公开(公告)日：2014-04-01
申请号：US12452482
申请日：2008-07-02
申请人： Moshe Gavish , Rafael M. Nagler
发明人： Moshe Gavish , Rafael M. Nagler
CPC分类号： A61K31/472 , A61K31/498 , A61K31/502 , A61K31/517 , A61K31/5513
摘要： Articles of manufacturing (such as tobacco products), methods, devices and compositions for preventing or reducing tobacco-associated damage and/or disorders associated with oxidative stress in a subject, and which utilize a TSPO receptor ligand (such as diazepam), are disclosed.
摘要翻译： 公开了用于预防或减少与受试者相关的烟草相关损伤和/或与氧化应激有关的障碍并且利用TSPO受体配体（例如地西泮））的制造用制品（例如烟草制品），方法，装置和组合物 。
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2.发明申请COMPOSITIONS, ARTICLES AND METHODS COMRISING TSPO LIGANDS FOR PREVENTING OR REDUCING TOBACCO-ASSOCIATED DAMAGE 有权用于预防或减少烟草相关损害的TSPO配体的组合物，文章和方法公开(公告)号：US20100179133A1
公开(公告)日：2010-07-15
申请号：US12452482
申请日：2008-07-02
申请人： Moshe Gavish , Rafael M. Nagler
发明人： Moshe Gavish , Rafael M. Nagler
IPC分类号： A61K31/55
CPC分类号： A61K31/472 , A61K31/498 , A61K31/502 , A61K31/517 , A61K31/5513
摘要： Articles of manufacturing (such as tobacco products), methods, devices and compositions for preventing or reducing tobacco-associated damage and/or disorders associated with oxidative stress in a subject, and which utilize a TSPO receptor ligand (such as diazepam), are disclosed.
摘要翻译： 公开了用于预防或减少与受试者相关的烟草相关损伤和/或与氧化应激有关的障碍并且利用TSPO受体配体（例如地西泮））的制造用制品（例如烟草制品），方法，装置和组合物 。
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3.发明申请COMPOSITIONS, ARTICLES AND METHODS FOR PREVENTING OR REDUCING TOBACCO-ASSOCIATED DAMAGE 审中-公开用于预防或减少烟草相关损害的组合物，文章和方法公开(公告)号：US20120012123A1
公开(公告)日：2012-01-19
申请号：US13238115
申请日：2011-09-21
申请人： Moshe Gavish , Rafael M. Nagler
发明人： Moshe Gavish , Rafael M. Nagler
CPC分类号： A61K31/195 , A23G3/36 , A23G4/06 , A24B15/32 , A24D3/14
摘要： Articles of manufacturing, methods, devices and compositions for preventing or reducing tobacco-associated damage in a subject, and which utilize a metal ion chelating agent, a copper chelating agent, a penicillamine and/or a structural analog of penicillamine, with and without an additional antioxidant, are disclosed.
摘要翻译： 使用金属离子螯合剂，铜螯合剂，青霉胺和/或青霉胺结构类似物的用于预防或减少烟草相关损害的制造方法，装置和组合物，具有和不具有 额外的抗氧化剂。
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公开(公告)号：US20100317040A1
公开(公告)日：2010-12-16
申请号：US12816482
申请日：2010-06-16
申请人： Rafael M. Nagler , Moshe Gavish
发明人： Rafael M. Nagler , Moshe Gavish
CPC分类号： G01N33/57407 , G01N33/57488
摘要： A method of diagnosing oral cancer or oral pharyngeal cancer in a subject in need thereof is provided. The method comprising determining a level or activity of at least one marker in a saliva sample of the subject, wherein a significant alteration in the level or the activity of the marker with respect to an unaffected saliva sample is indicative of the cancer, wherein the saliva marker is selected from the group consisting of Cyclin D1, phospho-Src, 8-oxoguanine DNA glycosylase (OGG1), Maspin, KI67 and translocator protein 18 kDa (TSPO).
摘要翻译： 提供了在有需要的受试者中诊断口腔癌或口咽癌的方法。 该方法包括确定受试者唾液样品中至少一种标记物的水平或活性，其中相对于未受影响的唾液样品的标记物的水平或活性的显着改变指示癌症，其中唾液 标记物选自细胞周期蛋白D1，磷酸化Src，8-氧基鸟嘌呤DNA糖基化酶（OGG1），Maspin，KI67和易位蛋白18kDa（TSPO）。
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公开(公告)号：US09075060B2
公开(公告)日：2015-07-07
申请号：US12816482
申请日：2010-06-16
申请人： Rafael M. Nagler , Moshe Gavish
发明人： Rafael M. Nagler , Moshe Gavish
IPC分类号： G01N33/574
CPC分类号： G01N33/57407 , G01N33/57488
摘要： A method of diagnosing oral cancer or oral pharyngeal cancer in a subject in need thereof is provided. The method comprising determining a level or activity of at least one marker in a saliva sample of the subject, wherein a significant alteration in the level or the activity of the marker with respect to an unaffected saliva sample is indicative of the cancer, wherein the saliva marker is selected from the group consisting of Cyclin D1, phospho-Src, 8-oxoguanine DNA glycosylase (OGG1), Maspin, KI67 and translocator protein 18 kDa (TSPO).
摘要翻译： 提供了在有需要的受试者中诊断口腔癌或口咽癌的方法。 该方法包括确定受试者唾液样品中至少一种标记物的水平或活性，其中相对于未受影响的唾液样品的标记物的水平或活性的显着改变指示癌症，其中唾液 标记物选自细胞周期蛋白D1，磷酸化Src，8-氧基鸟嘌呤DNA糖基化酶（OGG1），Maspin，KI67和易位蛋白18kDa（TSPO）。
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6.发明申请Compositions, articles and methods for preventing or reducing tobacco-associated damage 审中-公开用于预防或减少烟草相关损害的组合物，物品和方法公开(公告)号：US20100166833A1
公开(公告)日：2010-07-01
申请号：US12588825
申请日：2009-10-29
申请人： Moshe Gavish , Rafael M. Nagler
发明人： Moshe Gavish , Rafael M. Nagler
IPC分类号： A61K9/70 , A61K9/68 , A61K31/195
CPC分类号： A61K31/195 , A23G3/36 , A23G4/06 , A24B15/32 , A24D3/14
摘要： Articles of manufacturing, methods, devices and compositions for preventing or reducing tobacco-associated damage in a subject, and which utilize a metal ion chelating agent, a copper chelating agent, a penicillamine and/or a structural analog of penicillamine, with and without an additional antioxidant, are disclosed.
摘要翻译： 使用金属离子螯合剂，铜螯合剂，青霉胺和/或青霉胺结构类似物的用于预防或减少烟草相关损害的制造方法，装置和组合物，具有和不具有 额外的抗氧化剂。
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公开(公告)号：US20100021928A1
公开(公告)日：2010-01-28
申请号：US12306548
申请日：2007-06-25
申请人： Rafael M. Nagler , Moshe Gavish
发明人： Rafael M. Nagler , Moshe Gavish
CPC分类号： G01N33/57407 , G01N33/57488
摘要： Methods and kits for diagnosing cancer in a subject is disclosed. The method comprises determining a level and/or activity of at least one saliva secreted marker in a saliva sample of the subject wherein an alteration in said marker with respect to an unaffected saliva sample is indicative of the cancer, with the proviso that the saliva secreted marker is not circulatory carcinoembryonic antigen (CEA).
摘要翻译： 公开了用于诊断受试者中的癌症的方法和试剂盒。 该方法包括测定受试者唾液样品中至少一种唾液分泌标记物的水平和/或活性，其中所述标记物相对于未受影响的唾液样品的改变指示癌症，条件是分泌的唾液 标记物不是循环癌胚抗原（CEA）。
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8.发明申请TOBACCO AND TOBACCO PACKAGING MATERIAL FOR PREVENTING OR REDUCING TOBACCO-ASSOCIATED INJURY IN THE AERODIGESTIVE TRACT OF A SUBJECT 审中-公开烟草和烟草包装材料，用于防止或减少烟草相关伤害的物质公开(公告)号：US20100108086A1
公开(公告)日：2010-05-06
申请号：US12523995
申请日：2008-01-22
CPC分类号： A24B15/30 , A24B13/00 , A24B15/282 , A24D1/02 , A24D3/14
摘要： Articles of manufacturing for preventing or reducing tobacco smoke- and smokeless-tobacco associated injury in the aerodigestive tract of a subject are disclosed, which comprise at least one agent capable of reducing or preventing tobacco associated loss of peroxidase activity in said aerodigestive tract, said at least one agent being selected from the group consisting of a cyanide chelator and an iron chelator.
摘要翻译： 公开了用于预防或减少受试者的呼吸消化道中的烟草烟雾和无烟烟草相关损伤的制造用制品，其包含至少一种能够减少或防止烟草在所述呼吸消化道中过氧化物酶活性丧失的药剂， 至少一种试剂选自氰化物螯合剂和铁螯合剂。
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9.发明授权Filters for preventing or reducing tobacco smoke-associated injury in the aerodigestive tract of a subject 失效用于预防或减少受试者的消化道烟草烟雾相关损伤的过滤器公开(公告)号：US06789546B2
公开(公告)日：2004-09-14
申请号：US09987688
申请日：2001-11-15
申请人： Abraham Z. Reznick , Rafael M. Nagler , Ifat Klein
发明人： Abraham Z. Reznick , Rafael M. Nagler , Ifat Klein
IPC分类号： A24B1518
CPC分类号： A24D3/14 , A24B15/00 , A61K31/714
摘要： A method of preventing or reducing tobacco smoke-associated injury in the aerodigestive tract of a subject is disclosed. The method comprises administering a therapeutically effective amount of an antioxidant agent capable of preventing or reducing tobacco smoke-associated injury in the aerodigestive tract of a subject.
摘要翻译： 公开了一种在受试者的消气道中预防或减少烟草烟雾相关损伤的方法。 该方法包括施用治疗有效量的能够预防或减少受试者的呼吸消化道中的烟草烟雾相关损伤的抗氧化剂。
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