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1.发明授权Methods and compositions for the treatment of cancer and related hyperproliferative disorders 有权用于治疗癌症和相关过度增生性疾病的方法和组合物公开(公告)号：US09187485B2
公开(公告)日：2015-11-17
申请号：US14052074
申请日：2013-10-11
IPC分类号： C07D213/06 , C07D277/24 , C07D417/04 , C07D487/04 , C07D417/14 , A61K31/4439 , A61K31/454 , A61K31/496 , C07D213/76 , C07D235/14 , C07D417/12 , C07D277/22 , C07D213/16 , A61K31/427 , A61K31/428 , C07D471/04 , C07D277/66 , A61K31/437
CPC分类号： A61K31/5025 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , C07D213/06 , C07D213/16 , C07D213/76 , C07D235/14 , C07D277/22 , C07D277/24 , C07D277/66 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to methods of treating a disease related to cell hyper-proliferation via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B-C. In the tripartite structure A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. The methods may utilize particular compounds, for example, having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently.
摘要翻译： 本发明涉及通过给予治疗有效量的具有一般三分体结构A-B-C的化合物治疗与细胞增殖相关的疾病的方法。 三方结构A，B和C是相同或不相同的结构，例如但不限于具有或不具有取代的杂环，苯基或苄基环结构，并在此详细描述。 该方法可以使用具体的化合物，例如具有哌啶基，吡咯啉基或吡啶基A环，噻唑B环和可以独立地进一步取代的苯基C环。
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2.发明授权公开(公告)号：US09713613B2
公开(公告)日：2017-07-25
申请号：US14940584
申请日：2015-11-13
IPC分类号： A61K31/5025 , A61K31/4709 , A61K31/496 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/4439 , A61K31/44 , C07D487/04 , C07D417/04 , C07D417/14 , C07D277/24 , C07D213/06 , C07D213/76 , C07D235/14 , C07D417/12 , C07D277/22 , C07D213/16 , A61K31/428 , C07D471/04 , C07D277/66 , A61K31/437
CPC分类号： A61K31/5025 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , C07D213/06 , C07D213/16 , C07D213/76 , C07D235/14 , C07D277/22 , C07D277/24 , C07D277/66 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to methods of treating a disease related to cell hyper-proliferation via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B-C. In the tripartite structure A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. The methods may utilize particular compounds, for example, having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently.
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3.发明申请Methods and Compositions for the Treatment of Cancer and Related Hyperproliferative Disorders 审中-公开用于治疗癌症和相关的过度增生性疾病的方法和组合物公开(公告)号：US20160136164A1
公开(公告)日：2016-05-19
申请号：US14940584
申请日：2015-11-13
IPC分类号： A61K31/5025 , A61K31/4709 , A61K31/496 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/4439 , A61K31/44
CPC分类号： A61K31/5025 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , C07D213/06 , C07D213/16 , C07D213/76 , C07D235/14 , C07D277/22 , C07D277/24 , C07D277/66 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to methods of treating a disease related to cell hyper-proliferation via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B—C. In the tripartite structure A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. The methods may utilize particular compounds, for example, having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently.
摘要翻译： 本发明涉及通过给予治疗有效量的具有一般三分体结构A-B-C的化合物治疗与细胞增殖相关的疾病的方法。 三方结构A，B和C是相同或不相同的结构，例如但不限于具有或不具有取代的杂环，苯基或苄基环结构，并在此详细描述。 该方法可以使用具体的化合物，例如具有哌啶基，吡咯啉基或吡啶基A环，噻唑B环和可以独立地进一步取代的苯基C环。
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4.发明申请公开(公告)号：US20160128985A1
公开(公告)日：2016-05-12
申请号：US14991518
申请日：2016-01-08
IPC分类号： A61K31/427 , A61K31/437 , A61K45/06 , A61K31/5025 , A61K31/454 , A61K31/496 , A61K31/428 , A61K31/4439
CPC分类号： A61K31/427 , A23K20/137 , A23L33/10 , A61K31/428 , A61K31/437 , A61K31/4418 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/5025 , A61K45/06 , C07D213/06 , C07D213/16 , C07D213/76 , C07D235/14 , C07D277/22 , C07D277/24 , C07D277/66 , C07D401/04 , C07D401/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to methods for reducing body weight in an animal in need thereof via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B-C. In the tripartite structure A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. The methods may utilize particular compounds, for example, having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently. Also provided are methods for increasing thermogenesis without reducing lean body mass during weight loss in an animal by administering of a therapeutically effective amount of the compounds described.
摘要翻译： 本发明涉及通过给予治疗有效量的具有一般三分体结构A-B-C的化合物来减少有需要的动物体重的方法。 三方结构A，B和C是相同或不相同的结构，例如但不限于具有或不具有取代的杂环，苯基或苄基环结构，并在此详细描述。 该方法可以使用具体的化合物，例如具有哌啶基，吡咯啉基或吡啶基A环，噻唑B环和可以独立地进一步取代的苯基C环。 还提供了通过施用治疗有效量的所述化合物来增加产热而不减少体重减轻中的瘦体重的方法。
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5.发明申请Compositions and Methods for the Treatment of Metabolic and Related Disorders 审中-公开用于治疗代谢和相关疾病的组合物和方法公开(公告)号：US20150307501A1
公开(公告)日：2015-10-29
申请号：US14799720
申请日：2015-07-15
IPC分类号： C07D487/04 , A61K31/4439 , C07D277/24 , A61K31/426 , C07D417/14 , A61K31/4709 , C07D213/16 , A61K31/4418 , A61K31/454 , A61K31/5025 , C07D213/76 , A61K31/496 , C07D295/073 , A61K31/495 , C07D235/14 , C07D417/04
CPC分类号： C07D487/04 , A61K31/426 , A61K31/4418 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/5025 , A61K45/06 , C07D213/16 , C07D213/76 , C07D235/14 , C07D277/22 , C07D277/24 , C07D277/52 , C07D295/073 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to the compound for treatment and/or prevention of one or more metabolic disorders utilizes an A-B-C tripartite structure, wherein A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. Also provided are methods for the treatment and/or prevention of one or more metabolic disorders, for example, obesity or diabetes, utilizing fatostatin A and/or a derivative and/or analog thereof and/or the A-B-C tripartite compounds.
摘要翻译： 本发明涉及用于治疗和/或预防一种或多种代谢紊乱的化合物利用ABC三方结构，其中A，B和C是相同或不相同的结构，例如但不限于杂环， 具有或不具有取代的苯基或苄基环结构，并在此详细描述。 还提供了使用脂肪抑制素A和/或其衍生物和/或类似物和/或A-B-C三分体化合物治疗和/或预防一种或多种代谢紊乱（例如肥胖症或糖尿病）的方法。
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6.发明授权公开(公告)号：US09085566B2
公开(公告)日：2015-07-21
申请号：US14013918
申请日：2013-08-29
IPC分类号： A61K31/427 , A61K31/4025 , C07D417/04 , C07D403/04 , A61K31/4439 , C07D277/24 , A61K31/426 , C07D213/16 , A61K31/4418 , A61K31/454 , C07D213/76 , A61K31/496 , C07D235/14 , C07D417/12 , A61K45/06 , C07D417/14 , C07D277/22 , C07D471/04 , C07D487/04 , C07D277/52
CPC分类号： C07D487/04 , A61K31/426 , A61K31/4418 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/5025 , A61K45/06 , C07D213/16 , C07D213/76 , C07D235/14 , C07D277/22 , C07D277/24 , C07D277/52 , C07D295/073 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to the compound for treatment and/or prevention of one or more metabolic disorders utilizes an A-B-C tripartite structure, wherein A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. Also provided are methods for the treatment and/or prevention of one or more metabolic disorders, for example, obesity or diabetes, utilizing fatostatin A and/or a derivative and/or analog thereof and/or the A-B-C tripartite compounds.
摘要翻译： 本发明涉及用于治疗和/或预防一种或多种代谢紊乱的化合物利用ABC三方结构，其中A，B和C是相同或不相同的结构，例如但不限于杂环， 具有或不具有取代的苯基或苄基环结构，并在此详细描述。 还提供了使用脂肪抑制素A和/或其衍生物和/或类似物和/或A-B-C三分体化合物治疗和/或预防一种或多种代谢紊乱（例如肥胖症或糖尿病）的方法。
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7.发明授权公开(公告)号：US09233941B2
公开(公告)日：2016-01-12
申请号：US14270130
申请日：2014-05-05
IPC分类号： A61K31/427 , A61K31/4436 , A61K31/4439 , C07D277/66 , C07D417/04 , A61K45/06 , A61K31/428 , C07D471/04 , A61K31/437 , C07D417/12 , C07D417/14 , A61K31/4709 , A61K31/454 , C07D401/14 , C07D401/04 , A61K31/496 , A23L1/30 , A23K1/16 , C07D213/76 , C07D235/14 , C07D487/04 , C07D277/22 , C07D277/24 , C07D213/06 , C07D213/16 , A61K31/4418 , A61K31/495 , A61K31/5025
CPC分类号： A61K31/427 , A23K20/137 , A23L33/10 , A61K31/428 , A61K31/437 , A61K31/4418 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/5025 , A61K45/06 , C07D213/06 , C07D213/16 , C07D213/76 , C07D235/14 , C07D277/22 , C07D277/24 , C07D277/66 , C07D401/04 , C07D401/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to methods for reducing body weight in an animal in need thereof via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B-C. In the tripartite structure A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. The methods may utilize particular compounds, for example, having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently. Also provided are methods for increasing thermogenesis without reducing lean body mass during weight loss in an animal by administering of a therapeutically effective amount of the compounds described.
摘要翻译： 本发明涉及通过给予治疗有效量的具有一般三分体结构A-B-C的化合物来减少有需要的动物体重的方法。 三方结构A，B和C是相同或不相同的结构，例如但不限于具有或不具有取代的杂环，苯基或苄基环结构，并在此详细描述。 该方法可以使用具体的化合物，例如具有哌啶基，吡咯啉基或吡啶基A环，噻唑B环和可以独立地进一步取代的苯基C环。 还提供了通过施用治疗有效量的所述化合物来增加产热而不减少体重减轻中的瘦体重的方法。
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公开(公告)号：US09212179B2
公开(公告)日：2015-12-15
申请号：US14310339
申请日：2014-06-20
IPC分类号： C07D417/04 , C07D277/24 , C07D417/14 , C07D277/10 , C07D277/22
CPC分类号： C07D417/04 , C07D277/10 , C07D277/22 , C07D277/24 , C07D417/14
摘要： The present invention relates to the compound for treatment and/or prevention of one or more metabolic disorders utilizes an A-B-C tripartite structure, wherein A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. Also provided are methods for the treatment and/or prevention of one or more metabolic disorders, for example, obesity or diabetes, utilizing fatostatin A and/or a derivative and/or analog thereof and/or the A-B-C tripartite compounds.
摘要翻译： 本发明涉及用于治疗和/或预防一种或多种代谢紊乱的化合物利用ABC三方结构，其中A，B和C是相同或不相同的结构，例如但不限于杂环， 具有或不具有取代的苯基或苄基环结构，并在此详细描述。 还提供了使用脂肪抑制素A和/或其衍生物和/或类似物和/或A-B-C三分体化合物治疗和/或预防一种或多种代谢紊乱（例如肥胖症或糖尿病）的方法。
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公开(公告)号：US20140303213A1
公开(公告)日：2014-10-09
申请号：US14310339
申请日：2014-06-20
IPC分类号： C07D417/04 , C07D277/24
CPC分类号： C07D417/04 , C07D277/10 , C07D277/22 , C07D277/24 , C07D417/14
摘要： The present invention relates to the compound for treatment and/or prevention of one or more metabolic disorders utilizes an A-B-C tripartite structure, wherein A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. Also provided are methods for the treatment and/or prevention of one or more metabolic disorders, for example, obesity or diabetes, utilizing fatostatin A and/or a derivative and/or analog thereof and/or the A-B-C tripartite compounds.
摘要翻译： 本发明涉及用于治疗和/或预防一种或多种代谢紊乱的化合物利用ABC三方结构，其中A，B和C是相同或不相同的结构，例如但不限于杂环， 具有或不具有取代的苯基或苄基环结构，并在此详细描述。 还提供了使用脂肪抑制素A和/或其衍生物和/或类似物和/或A-B-C三分体化合物治疗和/或预防一种或多种代谢紊乱（例如肥胖症或糖尿病）的方法。
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公开(公告)号：US20130012538A1
公开(公告)日：2013-01-10
申请号：US13484702
申请日：2012-05-31
申请人： Motonari Uesugi , Salih J. Wakil , Lutfi Abu-Elheiga , Qian Mao , Shinji Kamisuki , Akira Kugimiya
发明人： Motonari Uesugi , Salih J. Wakil , Lutfi Abu-Elheiga , Qian Mao , Shinji Kamisuki , Akira Kugimiya
IPC分类号： A61K31/4439 , A61K31/4709 , A61P3/06 , A61P3/00 , A61P9/12 , A61P35/00 , A61P9/00 , A61K31/425 , A61P3/10
CPC分类号： A61K31/4439 , A61K31/426 , A61K31/4709 , C07D277/10 , C07D277/22 , C07D277/24 , C07D417/04 , C07D417/14
摘要： The present invention relates to treatment and/or prevention of one or more metabolic disorders utilizing fatostatin A and/or a derivative and/or analog thereof. In other aspects, the compound for treatment and/or prevention of one or more metabolic disorders utilizes an A-B-C tripartite structure, wherein A, B, and C are identical or non-identical structures and are described in detail herein. In specific aspects, the metabolic disorder includes obesity or diabetes, for example.
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